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Items: 1 to 20 of 93


Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications.

McClure M, DeLucas LJ, Wilson L, Ray M, Rowe SM, Wu X, Dai Q, Hong JS, Sorscher EJ, Kappes JC, Barnes S.

Protein Eng Des Sel. 2012 Jan;25(1):7-14. doi: 10.1093/protein/gzr054. Epub 2011 Nov 25.


Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.

McClure ML, Barnes S, Brodsky JL, Sorscher EJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L719-L733. doi: 10.1152/ajplung.00431.2015. Epub 2016 Jul 29. Review.


S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment.

McClure ML, Wen H, Fortenberry J, Hong JS, Sorscher EJ.

Biochem J. 2014 Apr 15;459(2):417-25. doi: 10.1042/BJ20131037.


Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools.

Lee S, Henderson MJ, Schiffhauer E, Despanie J, Henry K, Kang PW, Walker D, McClure ML, Wilson L, Sorscher EJ, Zeitlin PL.

Mol Cell Biol. 2014 Jul;34(14):2554-65.


A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface.

Hildebrandt E, Ding H, Mulky A, Dai Q, Aleksandrov AA, Bajrami B, Diego PA, Wu X, Ray M, Naren AP, Riordan JR, Yao X, DeLucas LJ, Urbatsch IL, Kappes JC.

Mol Biotechnol. 2015 May;57(5):391-405. doi: 10.1007/s12033-014-9830-5. Erratum in: Mol Biotechnol. 2015 May;57(5):406.


Expression and purification of the cystic fibrosis transmembrane conductance regulator protein in Saccharomyces cerevisiae.

O'Ryan L, Rimington T, Cant N, Ford RC.

J Vis Exp. 2012 Mar 10;(61). pii: 3860. doi: 10.3791/3860.


Characterizing diverse orthologues of the cystic fibrosis transmembrane conductance regulator protein for structural studies.

Pollock NL, Rimington TL, Ford RC.

Biochem Soc Trans. 2015 Oct;43(5):894-900. doi: 10.1042/BST20150081. Review.


Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways.

Ahner A, Gong X, Frizzell RA.

FEBS J. 2013 Sep;280(18):4430-8. doi: 10.1111/febs.12415. Epub 2013 Jul 22. Review.


The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

Pasyk S, Molinski S, Ahmadi S, Ramjeesingh M, Huan LJ, Chin S, Du K, Yeger H, Taylor P, Moran MF, Bear CE.

Proteomics. 2015 Jan;15(2-3):447-61. doi: 10.1002/pmic.201400218. Epub 2014 Dec 17.


Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.

Dong Q, Ostedgaard LS, Rogers C, Vermeer DW, Zhang Y, Welsh MJ.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):917-22. doi: 10.1073/pnas.1120065109. Epub 2011 Dec 30.


Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi.

Farinha CM, Matos P, Amaral MD.

FEBS J. 2013 Sep;280(18):4396-406. doi: 10.1111/febs.12392. Epub 2013 Jul 5. Review.


Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels.

Saxena A, Banasavadi-Siddegowda YK, Fan Y, Bhattacharya S, Roy G, Giovannucci DR, Frizzell RA, Wang X.

J Biol Chem. 2012 Jun 1;287(23):19158-70. doi: 10.1074/jbc.M111.297580. Epub 2012 Apr 13.


A novel procedure for the efficient purification of the cystic fibrosis transmembrane conductance regulator (CFTR).

Ramjeesingh M, Li C, Garami E, Huan LJ, Hewryk M, Wang Y, Galley K, Bear CE.

Biochem J. 1997 Oct 1;327 ( Pt 1):17-21.


Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.

Aleksandrov AA, Kota P, Aleksandrov LA, He L, Jensen T, Cui L, Gentzsch M, Dokholyan NV, Riordan JR.

J Mol Biol. 2010 Aug 13;401(2):194-210. doi: 10.1016/j.jmb.2010.06.019. Epub 2010 Jun 16.


A conserved region of the R domain of cystic fibrosis transmembrane conductance regulator is important in processing and function.

Pasyk EA, Morin XK, Zeman P, Garami E, Galley K, Huan LJ, Wang Y, Bear CE.

J Biol Chem. 1998 Nov 27;273(48):31759-64.


The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

Thibodeau PH, Richardson JM 3rd, Wang W, Millen L, Watson J, Mendoza JL, Du K, Fischman S, Senderowitz H, Lukacs GL, Kirk K, Thomas PJ.

J Biol Chem. 2010 Nov 12;285(46):35825-35. doi: 10.1074/jbc.M110.131623. Epub 2010 Jul 28.


Defects in processing and trafficking of cystic fibrosis transmembrane conductance regulator.

Kunzelmann K, Nitschke R.

Exp Nephrol. 2000 Nov-Dec;8(6):332-42. Review.


Biosynthesis of cystic fibrosis transmembrane conductance regulator.

Pranke IM, Sermet-Gaudelus I.

Int J Biochem Cell Biol. 2014 Jul;52:26-38. doi: 10.1016/j.biocel.2014.03.020. Epub 2014 Mar 28. Review.


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