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The ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM1 during growth on acetate.

Schneider K, Peyraud R, Kiefer P, Christen P, Delmotte N, Massou S, Portais JC, Vorholt JA.

J Biol Chem. 2012 Jan 2;287(1):757-66. doi: 10.1074/jbc.M111.305219. Epub 2011 Nov 21.


Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1.

Good NM, Martinez-Gomez NC, Beck DA, Lidstrom ME.

J Bacteriol. 2015 Feb 15;197(4):727-35. doi: 10.1128/JB.02478-14. Epub 2014 Dec 1.


Oxalyl-coenzyme A reduction to glyoxylate is the preferred route of oxalate assimilation in Methylobacterium extorquens AM1.

Schneider K, Skovran E, Vorholt JA.

J Bacteriol. 2012 Jun;194(12):3144-55. doi: 10.1128/JB.00288-12. Epub 2012 Apr 6.


Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics.

Peyraud R, Kiefer P, Christen P, Massou S, Portais JC, Vorholt JA.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4846-51. doi: 10.1073/pnas.0810932106. Epub 2009 Mar 4.


Metabolomics Revealed an Association of Metabolite Changes and Defective Growth in Methylobacterium extorquens AM1 Overexpressing ecm during Growth on Methanol.

Cui J, Good NM, Hu B, Yang J, Wang Q, Sadilek M, Yang S.

PLoS One. 2016 Apr 26;11(4):e0154043. doi: 10.1371/journal.pone.0154043. eCollection 2016.


Alternative route for glyoxylate consumption during growth on two-carbon compounds by Methylobacterium extorquens AM1.

Okubo Y, Yang S, Chistoserdova L, Lidstrom ME.

J Bacteriol. 2010 Apr;192(7):1813-23. doi: 10.1128/JB.01166-09. Epub 2010 Jan 29.


Glyoxylate regeneration pathway in the methylotroph Methylobacterium extorquens AM1.

Korotkova N, Chistoserdova L, Kuksa V, Lidstrom ME.

J Bacteriol. 2002 Mar;184(6):1750-8.


Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway.

Erb TJ, Berg IA, Brecht V, Müller M, Fuchs G, Alber BE.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10631-6. Epub 2007 Jun 4.


Thioesterases for ethylmalonyl-CoA pathway derived dicarboxylic acid production in Methylobacterium extorquens AM1.

Sonntag F, Buchhaupt M, Schrader J.

Appl Microbiol Biotechnol. 2014 May;98(10):4533-44. doi: 10.1007/s00253-013-5456-y. Epub 2014 Jan 14.


Genome-scale reconstruction and system level investigation of the metabolic network of Methylobacterium extorquens AM1.

Peyraud R, Schneider K, Kiefer P, Massou S, Vorholt JA, Portais JC.

BMC Syst Biol. 2011 Nov 10;5:189. doi: 10.1186/1752-0509-5-189.


Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply.

Liang WF, Cui LY, Cui JY, Yu KW, Yang S, Wang TM, Guan CG, Zhang C, Xing XH.

Metab Eng. 2017 Jan;39:159-168. doi: 10.1016/j.ymben.2016.11.010. Epub 2016 Dec 3.


(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation.

Erb TJ, Fuchs G, Alber BE.

Mol Microbiol. 2009 Sep;73(6):992-1008. doi: 10.1111/j.1365-2958.2009.06837.x. Epub 2009 Aug 23.


Multiple pathways for acetate assimilation in Streptomyces cinnamonensis.

Akopiants K, Florova G, Li C, Reynolds KA.

J Ind Microbiol Biotechnol. 2006 Feb;33(2):141-50. Epub 2005 Sep 27.


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