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Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.

Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernández-Montes RD, Gratacòs M, Pumarola M, Cabrera R, Maldonado R, Sabrià J, Estivill X, Dierssen M.

Amino Acids. 2012 Aug;43(2):897-909. doi: 10.1007/s00726-011-1149-y. Epub 2011 Nov 19.


Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice.

Molas S, Gener T, Güell J, Martín M, Ballesteros-Yáñez I, Sanchez-Vives MV, Dierssen M.

Acta Neuropathol Commun. 2014 Nov 11;2:147. doi: 10.1186/s40478-014-0147-1.


Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.

Wen L, Jiang K, Yuan W, Cui W, Li MD.

Mol Neurobiol. 2016 Jan;53(1):472-484. doi: 10.1007/s12035-014-8997-x. Epub 2014 Dec 5. Review.


The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.

Improgo MR, Scofield MD, Tapper AR, Gardner PD.

Prog Neurobiol. 2010 Oct;92(2):212-26. doi: 10.1016/j.pneurobio.2010.05.003. Epub 2010 Jun 4. Review.


An association study on the CHRNA5/A3/B4 gene cluster, smoking and psoriasis vulgaris.

Zhu KJ, Liu Z, Liu H, Li SJ, Zhu CY, Li KS, Fan YM.

Arch Dermatol Res. 2014 Dec;306(10):939-44. doi: 10.1007/s00403-014-1510-6. Epub 2014 Oct 9.


Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

Li MD, Xu Q, Lou XY, Payne TJ, Niu T, Ma JZ.

Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):745-56. doi: 10.1002/ajmg.b.31043.


ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.

Improgo MR, Schlichting NA, Cortes RY, Zhao-Shea R, Tapper AR, Gardner PD.

Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.


Molecular mechanisms underlying behaviors related to nicotine addiction.

Picciotto MR, Kenny PJ.

Cold Spring Harb Perspect Med. 2013 Jan 1;3(1):a012112. doi: 10.1101/cshperspect.a012112. Review.


The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.

Lubke GH, Stephens SH, Lessem JM, Hewitt JK, Ehringer MA.

Behav Genet. 2012 Jul;42(4):636-46. doi: 10.1007/s10519-012-9529-y. Epub 2012 Mar 1.


CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

Zhu AZ, Renner CC, Hatsukami DK, Benowitz NL, Tyndale RF.

Addiction. 2013 Oct;108(10):1818-28. doi: 10.1111/add.12250. Epub 2013 Jul 5.


Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study.

Choquet H, Joslyn G, Lee A, Kasberger J, Robertson M, Brush G, Schuckit MA, White R, Jorgenson E.

Alcohol Clin Exp Res. 2013 Aug;37(8):1311-6. doi: 10.1111/acer.12099. Epub 2013 Mar 4.


Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.

Ngolab J, Liu L, Zhao-Shea R, Gao G, Gardner PD, Tapper AR.

J Neurosci. 2015 Jun 3;35(22):8570-8. doi: 10.1523/JNEUROSCI.4453-14.2015.


Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.

Chen LS, Xian H, Grucza RA, Saccone NL, Wang JC, Johnson EO, Breslau N, Hatsukami D, Bierut LJ.

Drug Alcohol Depend. 2012 Jun;123 Suppl 1:S42-51. doi: 10.1016/j.drugalcdep.2012.01.014. Epub 2012 Feb 13.


A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert MF.

PLoS Genet. 2008 Jul 11;4(7):e1000125. doi: 10.1371/journal.pgen.1000125.


The CHRNA5-A3-B4 gene cluster in nicotine addiction.

Berrettini WH, Doyle GA.

Mol Psychiatry. 2012 Sep;17(9):856-66. doi: 10.1038/mp.2011.122. Epub 2011 Oct 4. Review.


Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.

Frahm S, Slimak MA, Ferrarese L, Santos-Torres J, Antolin-Fontes B, Auer S, Filkin S, Pons S, Fontaine JF, Tsetlin V, Maskos U, Ibañez-Tallon I.

Neuron. 2011 May 12;70(3):522-35. doi: 10.1016/j.neuron.2011.04.013.


Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.

Baker TB, Weiss RB, Bolt D, von Niederhausern A, Fiore MC, Dunn DM, Piper ME, Matsunami N, Smith SS, Coon H, McMahon WM, Scholand MB, Singh N, Hoidal JR, Kim SY, Leppert MF, Cannon DS.

Nicotine Tob Res. 2009 Jul;11(7):785-96. doi: 10.1093/ntr/ntp064. Epub 2009 May 12.


Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.

Besson M, David V, Baudonnat M, Cazala P, Guilloux JP, Reperant C, Cloez-Tayarani I, Changeux JP, Gardier AM, Granon S.

Psychopharmacology (Berl). 2012 Mar;220(1):1-14. doi: 10.1007/s00213-011-2422-1. Epub 2011 Sep 8.


Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

Winterer G, Mittelstrass K, Giegling I, Lamina C, Fehr C, Brenner H, Breitling LP, Nitz B, Raum E, Müller H, Gallinat J, Gal A, Heim K, Prokisch H, Meitinger T, Hartmann AM, Möller HJ, Gieger C, Wichmann HE, Illig T, Dahmen N, Rujescu D.

Am J Med Genet B Neuropsychiatr Genet. 2010 Dec 5;153B(8):1448-58. doi: 10.1002/ajmg.b.31126. Epub 2010 Sep 30.


Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking.

Tyndale RF, Zhu AZ, George TP, Cinciripini P, Hawk LW Jr, Schnoll RA, Swan GE, Benowitz NL, Heitjan DF, Lerman C; PGRN-PNAT Research Group.

PLoS One. 2015 May 26;10(5):e0128109. doi: 10.1371/journal.pone.0128109. eCollection 2015.

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