Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 92

1.

GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells.

Joost S, Almada LL, Rohnalter V, Holz PS, Vrabel AM, Fernandez-Barrena MG, McWilliams RR, Krause M, Fernandez-Zapico ME, Lauth M.

Cancer Res. 2012 Jan 1;72(1):88-99. doi: 10.1158/0008-5472.CAN-10-4621. Epub 2011 Nov 15.

2.

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner.

Lei J, Ma J, Ma Q, Li X, Liu H, Xu Q, Duan W, Sun Q, Xu J, Wu Z, Wu E.

Mol Cancer. 2013 Jun 20;12:66. doi: 10.1186/1476-4598-12-66.

3.

The Activation of β1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer.

Duan W, Ma J, Ma Q, Xu Q, Lei J, Han L, Li X, Wang Z, Wu Z, Lv S, Ma Z, Liu M, Wang F, Wu E.

Curr Cancer Drug Targets. 2014;14(5):446-57.

PMID:
24720337
4.

Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer.

Onishi H, Kai M, Odate S, Iwasaki H, Morifuji Y, Ogino T, Morisaki T, Nakashima Y, Katano M.

Cancer Sci. 2011 Jun;102(6):1144-50. doi: 10.1111/j.1349-7006.2011.01912.x. Epub 2011 Mar 15.

5.

Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells.

Xu X, Su B, Xie C, Wei S, Zhou Y, Liu H, Dai W, Cheng P, Wang F, Xu X, Guo C.

PLoS One. 2014 Jul 29;9(7):e96441. doi: 10.1371/journal.pone.0096441. eCollection 2014.

6.

Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells.

Wu YS, Chung I, Wong WF, Masamune A, Sim MS, Looi CY.

Biochim Biophys Acta. 2017 Feb;1861(2):296-306. doi: 10.1016/j.bbagen.2016.10.006. Epub 2016 Oct 14.

PMID:
27750041
7.

Gli1 promotes transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells.

Liu Q, Sheng W, Dong M, Dong X, Dong Q, Li F.

Surgery. 2015 Jul;158(1):211-24. doi: 10.1016/j.surg.2015.03.016.

PMID:
25979438
8.

Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts.

Tang C, Mei L, Pan L, Xiong W, Zhu H, Ruan H, Zou C, Tang L, Iguchi T, Wu X.

Biochim Biophys Acta. 2015 Jul;1850(7):1438-48. doi: 10.1016/j.bbagen.2015.04.005. Epub 2015 Apr 15.

PMID:
25888497
9.

The glioma-associated oncogene homolog 1 promotes epithelial--mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail.

Min S, Xiaoyan X, Fanghui P, Yamei W, Xiaoli Y, Feng W.

Cancer Gene Ther. 2013 Jul;20(7):379-85. doi: 10.1038/cgt.2013.36. Epub 2013 Jun 21.

PMID:
23788111
10.

Grainyhead-like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression.

Nishino H, Takano S, Yoshitomi H, Suzuki K, Kagawa S, Shimazaki R, Shimizu H, Furukawa K, Miyazaki M, Ohtsuka M.

Cancer Med. 2017 Nov;6(11):2686-2696. doi: 10.1002/cam4.1212. Epub 2017 Sep 29.

11.
12.

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.

Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D.

Genes Dev. 2009 Jan 1;23(1):24-36. doi: 10.1101/gad.1753809.

13.

GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1.

Inaguma S, Riku M, Hashimoto M, Murakami H, Saga S, Ikeda H, Kasai K.

Cancer Res. 2013 Dec 15;73(24):7313-23. doi: 10.1158/0008-5472.CAN-13-2008. Epub 2013 Oct 28.

14.

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation.

Wang Y, Hsu JM, Kang Y, Wei Y, Lee PC, Chang SJ, Hsu YH, Hsu JL, Wang HL, Chang WC, Li CW, Liao HW, Chang SS, Xia W, Ko HW, Chou CK, Fleming JB, Wang H, Hwang RF, Chen Y, Qin J, Hung MC.

Cancer Res. 2016 Dec 1;76(23):7049-7058. Epub 2016 Oct 6.

15.

Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling.

Morifuji Y, Onishi H, Iwasaki H, Imaizumi A, Nakano K, Tanaka M, Katano M.

Cancer Sci. 2014 Mar;105(3):324-33. doi: 10.1111/cas.12348. Epub 2014 Feb 11.

16.

Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway.

Sun XD, Liu XE, Huang DS.

Oncol Rep. 2013 Jun;29(6):2401-7. doi: 10.3892/or.2013.2385. Epub 2013 Apr 4.

PMID:
23563640
17.

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.

Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y.

PLoS One. 2010 Jan 21;5(1):e8824. doi: 10.1371/journal.pone.0008824.

18.

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.

Mizuarai S, Kawagishi A, Kotani H.

Mol Cancer. 2009 Jul 6;8:44. doi: 10.1186/1476-4598-8-44.

19.

GLI1 modulates EMT in pancreatic cancer--letter.

Inaguma S, Kasai K, Hashimoto M, Ikeda H.

Cancer Res. 2012 Jul 15;72(14):3702-3; author reply 3704-5. doi: 10.1158/0008-5472.CAN-12-0379. Epub 2012 Jul 3. No abstract available.

20.

Embigin is overexpressed in pancreatic ductal adenocarcinoma and regulates cell motility through epithelial to mesenchymal transition via the TGF-β pathway.

Jung DE, Kim JM, Kim C, Song SY.

Mol Carcinog. 2016 May;55(5):633-45. doi: 10.1002/mc.22309. Epub 2015 Mar 14.

PMID:
25773908

Supplemental Content

Support Center