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Items: 1 to 20 of 91

1.

Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.

Koulnis M, Porpiglia E, Porpiglia PA, Liu Y, Hallstrom K, Hidalgo D, Socolovsky M.

Blood. 2012 Feb 2;119(5):1228-39. doi: 10.1182/blood-2011-07-365346. Epub 2011 Nov 15.

2.

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.

Tong W, Zhang J, Lodish HF.

Blood. 2005 Jun 15;105(12):4604-12. Epub 2005 Feb 10.

3.

Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice.

Akhtar RS, Klocke BJ, Strasser A, Roth KA.

J Histochem Cytochem. 2008 Oct;56(10):921-7. doi: 10.1369/jhc.2008.951749. Epub 2008 Jul 7.

4.

The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.

J Biol Chem. 2013 Oct 18;288(42):30009-18. doi: 10.1074/jbc.M112.443093. Epub 2013 Aug 28.

5.

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

Rubert J, Qian Z, Andraos R, Guthy DA, Radimerski T.

BMC Cancer. 2011 Jan 19;11:24. doi: 10.1186/1471-2407-11-24.

6.

Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis.

Menon MP, Karur V, Bogacheva O, Bogachev O, Cuetara B, Wojchowski DM.

J Clin Invest. 2006 Mar;116(3):683-94.

7.
8.

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.

Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, Daria D, Jegga AG, Geiger H, Aronow BJ, Molkentin JD, Macleod KF, Kalfa TA, Dorn GW 2nd.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6794-9. Epub 2007 Apr 9.

9.

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.

10.

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.

Dolznig H, Grebien F, Deiner EM, Stangl K, Kolbus A, Habermann B, Kerenyi MA, Kieslinger M, Moriggl R, Beug H, Müllner EW.

Oncogene. 2006 May 11;25(20):2890-900.

11.

ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo.

Sabbagh L, Pulle G, Liu Y, Tsitsikov EN, Watts TH.

J Immunol. 2008 Jun 15;180(12):8093-101.

12.

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity.

Ponassi R, Biasotti B, Tomati V, Bruno S, Poggi A, Malacarne D, Cimoli G, Salis A, Pozzi S, Miglino M, Damonte G, Cozzini P, Spyrakis F, Campanini B, Bagnasco L, Castagnino N, Tortolina L, Mumot A, Frassoni F, Daga A, Cilli M, Piccardi F, Monfardini I, Perugini M, Zoppoli G, D'Arrigo C, Pesenti R, Parodi S.

Cell Cycle. 2008 Oct;7(20):3211-24. Epub 2008 Oct 20. Erratum in: Cell Cycle. 2012 Oct 1;11(19):3703. Spyraki, Francesca [corrected to Spyrakis, Francesca].

PMID:
18843207
13.

Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.

Porpiglia E, Hidalgo D, Koulnis M, Tzafriri AR, Socolovsky M.

PLoS Biol. 2012 Aug;10(8):e1001383. doi: 10.1371/journal.pbio.1001383. Epub 2012 Aug 28.

15.

Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.

Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF.

Blood. 2001 Dec 1;98(12):3261-73.

17.

Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells.

Abutin RM, Chen J, Lung TK, Lloyd JA, Sawyer ST, Harada H.

Exp Hematol. 2009 Feb;37(2):151-8. doi: 10.1016/j.exphem.2008.10.008. Epub 2008 Dec 18.

18.

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.

Maeda T, Ito K, Merghoub T, Poliseno L, Hobbs RM, Wang G, Dong L, Maeda M, Dore LC, Zelent A, Luzzatto L, Teruya-Feldstein J, Weiss MJ, Pandolfi PP.

Dev Cell. 2009 Oct;17(4):527-40. doi: 10.1016/j.devcel.2009.09.005.

19.

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis.

Delbridge AR, Grabow S, Bouillet P, Adams JM, Strasser A.

Oncogene. 2015 Apr 2;34(14):1872-6. doi: 10.1038/onc.2014.132. Epub 2014 May 26.

PMID:
24858047
20.

Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis.

Zhang L, Xing D, Chen M.

Apoptosis. 2008 Jul;13(7):950-8. doi: 10.1007/s10495-008-0226-5. Epub 2008 May 24.

PMID:
18500555

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