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Items: 1 to 20 of 148

1.

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19222-7. doi: 10.1073/pnas.1116948108. Epub 2011 Nov 11.

2.

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.

Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG.

Mol Biol Cell. 2012 Jun;23(12):2388-98. doi: 10.1091/mbc.E12-03-0209. Epub 2012 Apr 25.

3.

Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.

Chauhan N, Han G, Somashekarappa N, Gable K, Dunn T, Kohlwein SD.

J Biol Chem. 2016 Jan 29;291(5):2524-34. doi: 10.1074/jbc.M115.693200. Epub 2015 Dec 3. Erratum in: J Biol Chem. 2017 Jun 2;292(22):9431.

4.

Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status.

García-Marqués S, Randez-Gil F, Dupont S, Garre E, Prieto JA.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1319-33. doi: 10.1016/j.bbamcr.2016.03.025. Epub 2016 Mar 28.

5.

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis.

Shimobayashi M, Oppliger W, Moes S, Jenö P, Hall MN.

Mol Biol Cell. 2013 Mar;24(6):870-81. doi: 10.1091/mbc.E12-10-0753. Epub 2013 Jan 30.

6.

Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.

Gururaj C, Federman RS, Chang A.

J Biol Chem. 2013 Jul 12;288(28):20453-63. doi: 10.1074/jbc.M113.472860. Epub 2013 Jun 4. Erratum in: J Biol Chem. 2015 Jan 16;290(3):1455. Federman, Ross [corrected to Federman, Ross S].

7.

Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.

Surlow BA, Cooley BM, Needham PG, Brodsky JL, Patton-Vogt J.

J Biol Chem. 2014 Nov 7;289(45):31591-604. doi: 10.1074/jbc.M114.581157. Epub 2014 Sep 25.

8.

Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress.

Guerreiro JF, Muir A, Ramachandran S, Thorner J, Sá-Correia I.

Biochem J. 2016 Dec 1;473(23):4311-4325. Epub 2016 Sep 26.

9.

Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast.

Liu M, Huang C, Polu SR, Schneiter R, Chang A.

J Cell Sci. 2012 May 15;125(Pt 10):2428-35. doi: 10.1242/jcs.100578. Epub 2012 Feb 10.

10.

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids.

Muir A, Ramachandran S, Roelants FM, Timmons G, Thorner J.

Elife. 2014 Oct 3;3. doi: 10.7554/eLife.03779.

11.

TOR complex 2-Ypk1 signaling maintains sphingolipid homeostasis by sensing and regulating ROS accumulation.

Niles BJ, Joslin AC, Fresques T, Powers T.

Cell Rep. 2014 Feb 13;6(3):541-52. doi: 10.1016/j.celrep.2013.12.040. Epub 2014 Jan 23. Erratum in: Cell Rep. 2014 Feb 13;6(3):592.

12.

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.

Niles BJ, Mogri H, Hill A, Vlahakis A, Powers T.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1536-41. doi: 10.1073/pnas.1117563109. Epub 2012 Jan 17.

13.

Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.

Sun Y, Taniguchi R, Tanoue D, Yamaji T, Takematsu H, Mori K, Fujita T, Kawasaki T, Kozutsumi Y.

Mol Cell Biol. 2000 Jun;20(12):4411-9.

14.

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control.

Han S, Lone MA, Schneiter R, Chang A.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5851-6. doi: 10.1073/pnas.0911617107. Epub 2010 Mar 8.

15.

Orm family proteins mediate sphingolipid homeostasis.

Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS.

Nature. 2010 Feb 25;463(7284):1048-53. doi: 10.1038/nature08787.

17.

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites.

Leskoske KL, Roelants FM, Marshall MNM, Hill JM, Thorner J.

Genetics. 2017 Sep;207(1):179-195. doi: 10.1534/genetics.117.1124. Epub 2017 Jul 24.

18.

TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.

Niles BJ, Powers T.

Mol Biol Cell. 2014 Dec 1;25(24):3962-72. doi: 10.1091/mbc.E14-06-1122. Epub 2014 Sep 24.

19.

TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae.

Roelants FM, Leskoske KL, Pedersen RT, Muir A, Liu JM, Finnigan GC, Thorner J.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00627-16. doi: 10.1128/MCB.00627-16. Print 2017 Apr 1.

20.

The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover.

Luo G, Gruhler A, Liu Y, Jensen ON, Dickson RC.

J Biol Chem. 2008 Apr 18;283(16):10433-44. doi: 10.1074/jbc.M709972200. Epub 2008 Feb 22.

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