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Items: 1 to 20 of 102

1.

Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys.

Xu N, Kwon S, Abbott DH, Geller DH, Dumesic DA, Azziz R, Guo X, Goodarzi MO.

PLoS One. 2011;6(11):e27286. doi: 10.1371/journal.pone.0027286. Epub 2011 Nov 4.

2.

Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys.

Abbott DH, Tarantal AF, Dumesic DA.

Am J Primatol. 2009 Sep;71(9):776-84. doi: 10.1002/ajp.20679.

3.

Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome.

Bruns CM, Baum ST, Colman RJ, Dumesic DA, Eisner JR, Jensen MD, Whigham LD, Abbott DH.

Int J Obes (Lond). 2007 Oct;31(10):1579-85. Epub 2007 May 1.

4.

Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys.

Abbott DH, Barnett DK, Levine JE, Padmanabhan V, Dumesic DA, Jacoris S, Tarantal AF.

Biol Reprod. 2008 Jul;79(1):154-63. doi: 10.1095/biolreprod.108.067702. Epub 2008 Apr 2.

5.

Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome.

Zhou R, Bird IM, Dumesic DA, Abbott DH.

J Clin Endocrinol Metab. 2005 Dec;90(12):6630-7. Epub 2005 Sep 20.

6.

Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome.

Abbott DH, Zhou R, Bird IM, Dumesic DA, Conley AJ.

Endocr Dev. 2008;13:145-58. doi: 10.1159/000134831. Review.

7.

Early embryonic androgen exposure induces transgenerational epigenetic and metabolic changes.

Xu N, Chua AK, Jiang H, Liu NA, Goodarzi MO.

Mol Endocrinol. 2014 Aug;28(8):1329-36. doi: 10.1210/me.2014-1042. Epub 2014 Jul 3.

8.

Disordered follicle development in ovaries of prenatally androgenized ewes.

Forsdike RA, Hardy K, Bull L, Stark J, Webber LJ, Stubbs S, Robinson JE, Franks S.

J Endocrinol. 2007 Feb;192(2):421-8.

9.

Comprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell.

Xu J, Bao X, Peng Z, Wang L, Du L, Niu W, Sun Y.

Oncotarget. 2016 May 10;7(19):27899-909. doi: 10.18632/oncotarget.8544.

10.

Genome-wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats.

Zhang D, Cong J, Shen H, Wu Q, Wu X.

Fertil Steril. 2014 Nov;102(5):1458-67. doi: 10.1016/j.fertnstert.2014.07.1203. Epub 2014 Aug 20.

PMID:
25150387
11.

Early origins of polycystic ovary syndrome.

Dumesic DA, Schramm RD, Abbott DH.

Reprod Fertil Dev. 2005;17(3):349-60. Review.

PMID:
15745643
12.

Genome-wide DNA methylation and gene expression patterns provide insight into polycystic ovary syndrome development.

Wang XX, Wei JZ, Jiao J, Jiang SY, Yu DH, Li D.

Oncotarget. 2014 Aug 30;5(16):6603-10.

13.

Androgens and polycystic ovary syndrome.

Nisenblat V, Norman RJ.

Curr Opin Endocrinol Diabetes Obes. 2009 Jun;16(3):224-31. doi: 10.1097/MED.0b013e32832afd4d. Review.

PMID:
19390322
14.

Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome.

Hogg K, Young JM, Oliver EM, Souza CJ, McNeilly AS, Duncan WC.

Endocrinology. 2012 Jan;153(1):450-61. doi: 10.1210/en.2011-1607. Epub 2011 Nov 15.

PMID:
22087026
15.

Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring.

Abbott DH, Bruns CR, Barnett DK, Dunaif A, Goodfriend TL, Dumesic DA, Tarantal AF.

Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E741-51. doi: 10.1152/ajpendo.00058.2010. Epub 2010 Aug 3.

16.

Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies.

Xita N, Tsatsoulis A.

J Clin Endocrinol Metab. 2006 May;91(5):1660-6. Epub 2006 Mar 7. Review.

PMID:
16522691
17.

Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys.

Nicol LE, O'Brien TD, Dumesic DA, Grogan T, Tarantal AF, Abbott DH.

PLoS One. 2014 Sep 10;9(9):e106527. doi: 10.1371/journal.pone.0106527. eCollection 2014.

18.

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome.

Kokosar M, Benrick A, Perfilyev A, Fornes R, Nilsson E, Maliqueo M, Behre CJ, Sazonova A, Ohlsson C, Ling C, Stener-Victorin E.

Sci Rep. 2016 Mar 15;6:22883. doi: 10.1038/srep22883. Erratum in: Sci Rep. 2016 May 09;6:25321.

19.

Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys.

Bruns CM, Baum ST, Colman RJ, Eisner JR, Kemnitz JW, Weindruch R, Abbott DH.

J Clin Endocrinol Metab. 2004 Dec;89(12):6218-23.

PMID:
15579780
20.

Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.

Jones MR, Brower MA, Xu N, Cui J, Mengesha E, Chen YD, Taylor KD, Azziz R, Goodarzi MO.

PLoS Genet. 2015 Aug 25;11(8):e1005455. doi: 10.1371/journal.pgen.1005455. eCollection 2015 Aug.

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