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IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood.

Sneller MC, Kopp WC, Engelke KJ, Yovandich JL, Creekmore SP, Waldmann TA, Lane HC.

Blood. 2011 Dec 22;118(26):6845-8. doi: 10.1182/blood-2011-09-377804. Epub 2011 Nov 8.


Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates.

Lugli E, Goldman CK, Perera LP, Smedley J, Pung R, Yovandich JL, Creekmore SP, Waldmann TA, Roederer M.

Blood. 2010 Oct 28;116(17):3238-48. doi: 10.1182/blood-2010-03-275438. Epub 2010 Jul 14.


IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques.

Villinger F, Miller R, Mori K, Mayne AE, Bostik P, Sundstrom JB, Sugimoto C, Ansari AA.

Vaccine. 2004 Sep 3;22(25-26):3510-21.


Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.

Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, Fleisher TA, Dubois SP, Perera LP, Stewart DM, Goldman CK, Bryant BR, Decker JM, Chen J, Worthy TA, Figg WD Sr, Peer CJ, Sneller MC, Lane HC, Yovandich JL, Creekmore SP, Roederer M, Waldmann TA.

J Clin Oncol. 2015 Jan 1;33(1):74-82. doi: 10.1200/JCO.2014.57.3329. Epub 2014 Nov 17.


Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication.

Pallikkuth S, Rogers K, Villinger F, Dosterii M, Vaccari M, Franchini G, Pahwa R, Pahwa S.

Vaccine. 2011 Nov 15;29(49):9229-38. doi: 10.1016/j.vaccine.2011.09.118. Epub 2011 Oct 11.


Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques.

Mueller YM, Petrovas C, Bojczuk PM, Dimitriou ID, Beer B, Silvera P, Villinger F, Cairns JS, Gracely EJ, Lewis MG, Katsikis PD.

J Virol. 2005 Apr;79(8):4877-85.


Safety and immunologic effects of IL-15 administration in nonhuman primates.

Berger C, Berger M, Hackman RC, Gough M, Elliott C, Jensen MC, Riddell SR.

Blood. 2009 Sep 17;114(12):2417-26. doi: 10.1182/blood-2008-12-189266. Epub 2009 Jul 15.


Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques.

Berger C, Berger M, Beard BC, Kiem HP, Gooley TA, Riddell SR.

PLoS One. 2013;8(2):e56268. doi: 10.1371/journal.pone.0056268. Epub 2013 Feb 13.


Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation.

Alpdogan O, Eng JM, Muriglan SJ, Willis LM, Hubbard VM, Tjoe KH, Terwey TH, Kochman A, van den Brink MR.

Blood. 2005 Jan 15;105(2):865-73. Epub 2004 Jul 27.


Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques.

Halwani R, Boyer JD, Yassine-Diab B, Haddad EK, Robinson TM, Kumar S, Parkinson R, Wu L, Sidhu MK, Phillipson-Weiner R, Pavlakis GN, Felber BK, Lewis MG, Shen A, Siliciano RF, Weiner DB, Sekaly RP.

J Immunol. 2008 Jun 15;180(12):7969-79.


TLR2 engagement on memory CD8(+) T cells improves their cytokine-mediated proliferation and IFN-gamma secretion in the absence of Ag.

Cottalorda A, Mercier BC, Mbitikon-Kobo FM, Arpin C, Teoh DY, McMichael A, Marvel J, Bonnefoy-BĂ©rard N.

Eur J Immunol. 2009 Oct;39(10):2673-81. doi: 10.1002/eji.200939627.


Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool.

Melchionda F, Fry TJ, Milliron MJ, McKirdy MA, Tagaya Y, Mackall CL.

J Clin Invest. 2005 May;115(5):1177-87. Epub 2005 Apr 7.


Interleukin-12-responding asialoGM1+CD8+ central memory-type T cells as precursor cells for interferon-gamma-producing killer T cells.

Kosaka A, Lee U, Wakita D, Matsubara N, Togashi Y, Nishimura S, Kitamura H, Nishimura T.

Cancer Sci. 2006 Nov;97(11):1236-41. Epub 2006 Sep 5. Erratum in: Cancer Sci. 2007 Mar;98(3):464.


Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells.

Yin J, Dai A, Kutzler MA, Shen A, Lecureux J, Lewis MG, Waldmann T, Weiner DB, Boyer JD.

AIDS. 2008 Sep 12;22(14):1739-48. doi: 10.1097/QAD.0b013e32830efdae.


Reciprocal responsiveness to interleukin-12 and interferon-alpha specifies human CD8+ effector versus central memory T-cell fates.

Ramos HJ, Davis AM, Cole AG, Schatzle JD, Forman J, Farrar JD.

Blood. 2009 May 28;113(22):5516-25. doi: 10.1182/blood-2008-11-188458. Epub 2009 Mar 18.


IL-15 is a growth factor and an activator of CD8 memory T cells.

Weng NP, Liu K, Catalfamo M, Li Y, Henkart PA.

Ann N Y Acad Sci. 2002 Dec;975:46-56. Review.


IL-15: targeting CD8+ T cells for immunotherapy.

Diab A, Cohen AD, Alpdogan O, Perales MA.

Cytotherapy. 2005;7(1):23-35. Review.


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