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Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.

Wu X, Bradley MJ, Cai Y, Kümmel D, De La Cruz EM, Barr FA, Reinisch KM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18672-7. doi: 10.1073/pnas.1110415108. Epub 2011 Nov 7.


Analysis of connecdenn 1-3 (DENN1A-C) GEF activity for Rab35.

Allaire PD, McPherson PS, Ritter B.

Methods Mol Biol. 2015;1298:217-31. doi: 10.1007/978-1-4939-2569-8_19.


Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation.

Langemeyer L, Nunes Bastos R, Cai Y, Itzen A, Reinisch KM, Barr FA.

Elife. 2014 Feb 11;3:e01623. doi: 10.7554/eLife.01623.


Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors.

Kulasekaran G, Nossova N, Marat AL, Lund I, Cremer C, Ioannou MS, McPherson PS.

J Biol Chem. 2015 Jul 17;290(29):17999-8008. doi: 10.1074/jbc.M115.636712. Epub 2015 Jun 8.


Rab35: GEFs, GAPs and effectors.

Chaineau M, Ioannou MS, McPherson PS.

Traffic. 2013 Nov;14(11):1109-17. doi: 10.1111/tra.12096. Epub 2013 Aug 21. Review.


Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA.

J Cell Biol. 2010 Oct 18;191(2):367-81. doi: 10.1083/jcb.201008051. Epub 2010 Oct 11.


A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p.

Dong G, Medkova M, Novick P, Reinisch KM.

Mol Cell. 2007 Feb 9;25(3):455-62.


uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways.

Levivier E, Goud B, Souchet M, Calmels TP, Mornon JP, Callebaut I.

Biochem Biophys Res Commun. 2001 Sep 28;287(3):688-95.


DENN domain proteins: regulators of Rab GTPases.

Marat AL, Dokainish H, McPherson PS.

J Biol Chem. 2011 Apr 22;286(16):13791-800. doi: 10.1074/jbc.R110.217067. Epub 2011 Feb 17. Review.


The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes.

Allaire PD, Marat AL, Dall'Armi C, Di Paolo G, McPherson PS, Ritter B.

Mol Cell. 2010 Feb 12;37(3):370-82. doi: 10.1016/j.molcel.2009.12.037.


Asymmetric coiled-coil structure with Guanine nucleotide exchange activity.

Sato Y, Shirakawa R, Horiuchi H, Dohmae N, Fukai S, Nureki O.

Structure. 2007 Feb;15(2):245-52.


Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases.

Ishida M, E Oguchi M, Fukuda M.

Cell Struct Funct. 2016 Jul 9;41(2):61-79. doi: 10.1247/csf.16008. Epub 2016 May 27. Review.


Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton.

Marat AL, Ioannou MS, McPherson PS.

Mol Biol Cell. 2012 Jan;23(1):163-75. doi: 10.1091/mbc.E11-05-0474. Epub 2011 Nov 9.


GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5·Vps9 system.

Uejima T, Ihara K, Goh T, Ito E, Sunada M, Ueda T, Nakano A, Wakatsuki S.

J Biol Chem. 2010 Nov 19;285(47):36689-97. doi: 10.1074/jbc.M110.152132. Epub 2010 Sep 10.


The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.

Marat AL, McPherson PS.

J Biol Chem. 2010 Apr 2;285(14):10627-37. doi: 10.1074/jbc.M109.050930. Epub 2010 Feb 12.


Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction.

Uejima T, Ihara K, Sunada M, Kawasaki M, Ueda T, Kato R, Nakano A, Wakatsuki S.

Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):345-51. doi: 10.1107/S0907444912047294. Epub 2013 Feb 16.


Crystal structure of the Sec4p.Sec2p complex in the nucleotide exchanging intermediate state.

Sato Y, Fukai S, Ishitani R, Nureki O.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8305-10. Epub 2007 May 8.


Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

Itzen A, Pylypenko O, Goody RS, Alexandrov K, Rak A.

EMBO J. 2006 Apr 5;25(7):1445-55. Epub 2006 Mar 16.


Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA.

Suh HY, Lee DW, Lee KH, Ku B, Choi SJ, Woo JS, Kim YG, Oh BH.

EMBO J. 2010 Jan 20;29(2):496-504. doi: 10.1038/emboj.2009.347. Epub 2009 Nov 26.

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