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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.

Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z.

Nature. 2011 Dec 1;480(7375):118-22. doi: 10.1038/nature10598.


PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z.

Cell. 2012 Aug 17;150(4):685-96. doi: 10.1016/j.cell.2012.07.018. Erratum in: Cell. 2014 Aug 28;158(5):1210.


Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis.

Lu Z.

Chin J Cancer. 2012 Jan;31(1):5-7. doi: 10.5732/cjc.011.10446. Epub 2011 Dec 23.


PKM2: a new player in the β-catenin game.

Canal F, Perret C.

Future Oncol. 2012 Apr;8(4):395-8. doi: 10.2217/fon.12.11.


EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z.

Mol Cell. 2012 Dec 14;48(5):771-84. doi: 10.1016/j.molcel.2012.09.028. Epub 2012 Nov 1.


PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.

Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W, Lu Z.

Nat Commun. 2016 Aug 3;7:12431. doi: 10.1038/ncomms12431.


ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z.

Nat Cell Biol. 2012 Dec;14(12):1295-304. doi: 10.1038/ncb2629. Epub 2012 Nov 25. Erratum in: Nat Cell Biol. 2013 Jan;15(1):124.


Nuclear PKM2 regulates the Warburg effect.

Yang W, Lu Z.

Cell Cycle. 2013 Oct 1;12(19):3154-8. doi: 10.4161/cc.26182. Epub 2013 Aug 26.


Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.

Lee CH, Hung HW, Hung PH, Shieh YS.

Mol Cancer. 2010 Mar 19;9:64. doi: 10.1186/1476-4598-9-64.


EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z.

Mol Cell. 2009 Nov 25;36(4):547-59. doi: 10.1016/j.molcel.2009.09.034.


MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells.

Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D.

PLoS One. 2011;6(11):e28234. doi: 10.1371/journal.pone.0028234. Epub 2011 Nov 28.


PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.

Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z.

Nat Commun. 2014 Nov 21;5:5566. doi: 10.1038/ncomms6566.


Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, Yamamoto H, Doki Y, Mori M, Ishii H.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15526-31. doi: 10.1073/pnas.1407717111. Epub 2014 Oct 13.


Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells.

Yang P, Li Z, Wang Y, Zhang L, Wu H, Li Z.

Biochem Biophys Res Commun. 2015 Apr 3;459(2):327-32. doi: 10.1016/j.bbrc.2015.02.112. Epub 2015 Feb 28.


Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells.

Wang LY, Liu YP, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL, Guleng B.

PLoS One. 2013 Jun 28;8(6):e67542. doi: 10.1371/journal.pone.0067542. Print 2013.


PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells.

Wu H, Li Z, Yang P, Zhang L, Fan Y, Li Z.

Cell Signal. 2014 Nov;26(11):2397-405. doi: 10.1016/j.cellsig.2014.07.024. Epub 2014 Jul 17.


Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.

Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34. doi: 10.1073/pnas.1014769108. Epub 2011 Feb 15.


Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.

Yu Z, Zhao X, Huang L, Zhang T, Yang F, Xie L, Song S, Miao P, Zhao L, Sun X, Liu J, Huang G.

J Biol Chem. 2013 Dec 6;288(49):35406-16. doi: 10.1074/jbc.M113.508226. Epub 2013 Oct 18.


Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.

Dong T, Yan Y, Chai H, Chen S, Xiong X, Sun D, Yu Y, Deng L, Cheng F.

Biomed Pharmacother. 2015 Feb;69:277-84. doi: 10.1016/j.biopha.2014.12.010. Epub 2014 Dec 19.


Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.

Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP.

Cancer Biol Ther. 2011 Dec 15;12(12):1101-13. doi: 10.4161/cbt.12.12.18703. Epub 2011 Dec 15.

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