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Items: 1 to 20 of 186

1.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM.

Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600.

2.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

3.

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.

Baker DJ, Perez-Terzic C, Jin F, Pitel KS, Niederländer NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM.

Nat Cell Biol. 2008 Jul;10(7):825-36. doi: 10.1038/ncb1744. Epub 2008 May 30. Erratum in: Nat Cell Biol. 2012 Jun;14(6):649. Pitel, Kevin [corrected to Pitel, Kevin S].

4.

The yin and yang of the Cdkn2a locus in senescence and aging.

Baker DJ, Jin F, van Deursen JM.

Cell Cycle. 2008 Sep 15;7(18):2795-802. Epub 2008 Sep 28.

5.

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.

6.
7.

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.

Baker DJ, Weaver RL, van Deursen JM.

Cell Rep. 2013 Apr 25;3(4):1164-74. doi: 10.1016/j.celrep.2013.03.028. Epub 2013 Apr 18.

8.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

9.

p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells.

Sandhu C, Peehl DM, Slingerland J.

Cancer Res. 2000 May 15;60(10):2616-22.

10.

Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients.

Gu Z, Cao X, Jiang J, Li L, Da Z, Liu H, Cheng C.

Cell Signal. 2012 Dec;24(12):2307-14. doi: 10.1016/j.cellsig.2012.07.012. Epub 2012 Jul 20.

PMID:
22820504
11.

Senescent cells: a novel therapeutic target for aging and age-related diseases.

Naylor RM, Baker DJ, van Deursen JM.

Clin Pharmacol Ther. 2013 Jan;93(1):105-16. doi: 10.1038/clpt.2012.193. Epub 2012 Dec 5. Review.

12.

Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice.

Cardenas JC, Owens AP 3rd, Krishnamurthy J, Sharpless NE, Whinna HC, Church FC.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):827-33. doi: 10.1161/ATVBAHA.110.221721. Epub 2011 Jan 13.

13.

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.

Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E.

Nat Cell Biol. 2006 Nov;8(11):1291-7. Epub 2006 Oct 8.

PMID:
17028578
14.

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.

Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, Takasugi M, Yamakoshi K, Sorimachi H, Kanda H, Ishikawa Y, Sone S, Nishioka Y, Ohtani N, Hara E.

Nat Commun. 2015 Apr 29;6:7035. doi: 10.1038/ncomms8035.

15.

p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.

Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I.

Nat Med. 2016 Apr;22(4):412-20. doi: 10.1038/nm.4054. Epub 2016 Mar 7.

PMID:
26950362
16.

Astrocyte senescence as a component of Alzheimer's disease.

Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C.

PLoS One. 2012;7(9):e45069. doi: 10.1371/journal.pone.0045069. Epub 2012 Sep 12.

17.

Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.

Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A.

Hypertension. 2008 Jul;52(1):123-9. doi: 10.1161/HYPERTENSIONAHA.107.099432. Epub 2008 May 26.

18.
19.

Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.

Attema JL, Pronk CJ, Norddahl GL, Nygren JM, Bryder D.

Oncogene. 2009 Jun 4;28(22):2238-43. doi: 10.1038/onc.2009.94. Epub 2009 Apr 27.

PMID:
19398954
20.

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.

Menendez JA, Cufí S, Oliveras-Ferraros C, Martin-Castillo B, Joven J, Vellon L, Vazquez-Martin A.

Aging (Albany NY). 2011 Nov;3(11):1063-77. Review.

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