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Items: 1 to 20 of 86

1.

The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.

Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ.

Dev Cell. 2011 Nov 15;21(5):835-47. doi: 10.1016/j.devcel.2011.09.011.

2.

Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.

Xu X, Keshwani M, Meyer K, Sarikas A, Taylor S, Pan ZQ.

J Biol Chem. 2012 Nov 23;287(48):40758-66. doi: 10.1074/jbc.M112.405209.

3.

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.

Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Muehlich S, Pfeiffer AF, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A.

Cell Signal. 2014 Feb;26(2):233-9. doi: 10.1016/j.cellsig.2013.11.005.

4.

An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: potential role in the treatment of sarcopenic obesity.

Kirk-Ballard H, Kilroy G, Day BC, Wang ZQ, Ribnicky DM, Cefalu WT, Floyd ZE.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S21-5. doi: 10.1016/j.nut.2014.02.027.

5.

Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.

Lee A, Hakuno F, Northcott P, Pessin JE, Rozakis Adcock M.

PLoS One. 2013;8(1):e55634. doi: 10.1371/journal.pone.0055634.

6.

Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).

Ge Y, Yoon MS, Chen J.

J Biol Chem. 2011 Oct 14;286(41):35675-82. doi: 10.1074/jbc.M111.262881.

7.

Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake.

Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R.

J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Retraction in: J Biol Chem. 2016 Jul 1;291(27):14392.

8.

PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.

Glass DJ.

Curr Top Microbiol Immunol. 2010;346:267-78. doi: 10.1007/82_2010_78. Review.

PMID:
20593312
9.

Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.

Lokireddy S, McFarlane C, Ge X, Zhang H, Sze SK, Sharma M, Kambadur R.

Mol Endocrinol. 2011 Nov;25(11):1936-49. doi: 10.1210/me.2011-1124. Erratum in: Mol Endocrinol. 2015 Jan;29(1):153. Retraction in: Mol Endocrinol. 2016 Feb;30(2):274.

PMID:
21964591
10.

Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.

Long YC, Cheng Z, Copps KD, White MF.

Mol Cell Biol. 2011 Feb;31(3):430-41. doi: 10.1128/MCB.00983-10.

11.

Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.

Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T.

Mol Cell Biol. 2009 Sep;29(17):4798-811. doi: 10.1128/MCB.01347-08.

12.

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.

Wiza C, Herzfeld de Wiza D, Nascimento EB, Lehr S, Al-Hasani H, Ouwens DM.

Diabetologia. 2013 May;56(5):1118-28. doi: 10.1007/s00125-013-2861-9.

PMID:
23460019
13.
14.

PTEN is a protein tyrosine phosphatase for IRS1.

Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, Jiang X.

Nat Struct Mol Biol. 2014 Jun;21(6):522-7. doi: 10.1038/nsmb.2828.

15.

Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.

Sandri M, Barberi L, Bijlsma AY, Blaauw B, Dyar KA, Milan G, Mammucari C, Meskers CG, Pallafacchina G, Paoli A, Pion D, Roceri M, Romanello V, Serrano AL, Toniolo L, Larsson L, Maier AB, Muñoz-Cánoves P, Musarò A, Pende M, Reggiani C, Rizzuto R, Schiaffino S.

Biogerontology. 2013 Jun;14(3):303-23. doi: 10.1007/s10522-013-9432-9.

PMID:
23686362
16.

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.

Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP.

Nature. 2013 Feb 21;494(7437):375-9. doi: 10.1038/nature11834.

PMID:
23354051
17.

Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.

Leng S, Zhang W, Zheng Y, Liberman Z, Rhodes CJ, Eldar-Finkelman H, Sun XJ.

J Endocrinol. 2010 Aug;206(2):171-81. doi: 10.1677/JOE-09-0456.

18.

Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.

Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S, Sarikas A.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3371-6. doi: 10.1073/pnas.1401556111.

19.

1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice.

Liu Q, Li X, Li C, Zheng Y, Peng G.

Molecules. 2015 Dec 4;20(12):21700-14. doi: 10.3390/molecules201219794.

20.

An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes.

Kirk-Ballard H, Wang ZQ, Acharya P, Zhang XH, Yu Y, Kilroy G, Ribnicky D, Cefalu WT, Floyd ZE.

PLoS One. 2013;8(2):e57112. doi: 10.1371/journal.pone.0057112.

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