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Items: 1 to 20 of 95

1.

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.

Lanthaler K, Bilsland E, Dobson PD, Moss HJ, Pir P, Kell DB, Oliver SG.

BMC Biol. 2011 Oct 24;9:70. doi: 10.1186/1741-7007-9-70.

2.

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

Dobson PD, Kell DB.

Nat Rev Drug Discov. 2008 Mar;7(3):205-20. doi: 10.1038/nrd2438. Review.

PMID:
18309312
3.

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only.

Kell DB, Dobson PD, Oliver SG.

Drug Discov Today. 2011 Aug;16(15-16):704-14. doi: 10.1016/j.drudis.2011.05.010. Epub 2011 May 23.

PMID:
21624498
4.

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so.

Kell DB, Dobson PD, Bilsland E, Oliver SG.

Drug Discov Today. 2013 Mar;18(5-6):218-39. doi: 10.1016/j.drudis.2012.11.008. Epub 2012 Nov 30.

PMID:
23207804
5.

Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.

Smith D, Artursson P, Avdeef A, Di L, Ecker GF, Faller B, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, van de Waterbeemd H, Sugano K, Testa B.

Mol Pharm. 2014 Jun 2;11(6):1727-38. doi: 10.1021/mp400713v. Epub 2014 May 6. Review.

PMID:
24724562
6.

Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.

Cocucci E, Kim JY, Bai Y, Pabla N.

Clin Pharmacol Ther. 2017 Jan;101(1):121-129. doi: 10.1002/cpt.545. Epub 2016 Nov 26. Review.

PMID:
27804130
7.

Coexistence of passive and carrier-mediated processes in drug transport.

Sugano K, Kansy M, Artursson P, Avdeef A, Bendels S, Di L, Ecker GF, Faller B, Fischer H, Gerebtzoff G, Lennernaes H, Senner F.

Nat Rev Drug Discov. 2010 Aug;9(8):597-614. doi: 10.1038/nrd3187. Review.

PMID:
20671764
8.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
9.

Membrane transport as a determinant of the hepatic elimination of drugs and metabolites.

Evans AM.

Clin Exp Pharmacol Physiol. 1996 Oct-Nov;23(10-11):970-4. Review.

PMID:
8911743
10.

Genomewide screen reveals a wide regulatory network for di/tripeptide utilization in Saccharomyces cerevisiae.

Cai H, Kauffman S, Naider F, Becker JM.

Genetics. 2006 Mar;172(3):1459-76. Epub 2005 Dec 15.

11.

From drug to protein: using yeast genetics for high-throughput target discovery.

Armour CD, Lum PY.

Curr Opin Chem Biol. 2005 Feb;9(1):20-4. Review.

PMID:
15701448
12.

Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.

Han S, Kim D.

PLoS Comput Biol. 2008 Aug 29;4(8):e1000162. doi: 10.1371/journal.pcbi.1000162.

13.

Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.

Yun CW, Ferea T, Rashford J, Ardon O, Brown PO, Botstein D, Kaplan J, Philpott CC.

J Biol Chem. 2000 Apr 7;275(14):10709-15.

14.

Implications of the dominant role of transporters in drug uptake by cells.

Dobson PD, Lanthaler K, Oliver SG, Kell DB.

Curr Top Med Chem. 2009;9(2):163-81. Review.

PMID:
19200003
15.

Genome-wide analysis of membrane transport using yeast knockout arrays.

Burston HE, Davey M, Conibear E.

Methods Mol Biol. 2008;457:29-39.

PMID:
19066017
17.

Yeast genomics and drug target identification.

Bharucha N, Kumar A.

Comb Chem High Throughput Screen. 2007 Sep;10(8):618-34. Review.

PMID:
18045076
18.

Localization and function of the yeast multidrug transporter Tpo1p.

Albertsen M, Bellahn I, Krämer R, Waffenschmidt S.

J Biol Chem. 2003 Apr 11;278(15):12820-5. Epub 2003 Jan 31.

19.

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

Di L, Artursson P, Avdeef A, Ecker GF, Faller B, Fischer H, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, Sugano K.

Drug Discov Today. 2012 Aug;17(15-16):905-12. doi: 10.1016/j.drudis.2012.03.015. Epub 2012 Apr 4. Review.

PMID:
22507594
20.

Frog intestinal sac as an in vitro method for the assessment of intestinal permeability in humans: Application to carrier transported drugs.

Franco M, Lopedota A, Trapani A, Cutrignelli A, Meleleo D, Micelli S, Trapani G.

Int J Pharm. 2008 Mar 20;352(1-2):182-8. Epub 2007 Dec 11.

PMID:
18055143

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