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Items: 1 to 20 of 147

1.

MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation.

Madala SK, Schmidt S, Davidson C, Ikegami M, Wert S, Hardie WD.

Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8. doi: 10.1165/rcmb.2011-0237OC. Epub 2011 Oct 20.

2.

Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72. doi: 10.1165/rcmb.2008-0377OC. Epub 2009 Feb 24.

3.

MEK inhibition suppresses the development of lung fibrosis in the bleomycin model.

Galuppo M, Esposito E, Mazzon E, Di Paola R, Paterniti I, Impellizzeri D, Cuzzocrea S.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Jul;384(1):21-37. doi: 10.1007/s00210-011-0637-7. Epub 2011 May 2.

PMID:
21533992
4.

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.

5.

Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway.

Meng Y, Yu CH, Li W, Li T, Luo W, Huang S, Wu PS, Cai SX, Li X.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.

PMID:
24168260
6.

Opposing effects of protein kinase Calpha and protein kinase Cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling.

Tourkina E, Gooz P, Pannu J, Bonner M, Scholz D, Hacker S, Silver RM, Trojanowska M, Hoffman S.

J Biol Chem. 2005 Apr 8;280(14):13879-87. Epub 2005 Feb 3.

7.
8.

Glycosyltransferases and glycosaminoglycans in bleomycin and transforming growth factor-β1-induced pulmonary fibrosis.

Venkatesan N, Tsuchiya K, Kolb M, Farkas L, Bourhim M, Ouzzine M, Ludwig MS.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):583-94. doi: 10.1165/rcmb.2012-0226OC.

PMID:
24127863
9.

Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.

Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA, Lee CG.

J Biol Chem. 2012 Dec 7;287(50):41991-2000. doi: 10.1074/jbc.M112.356824. Epub 2012 Oct 19.

10.

ERK5 inhibition ameliorates pulmonary fibrosis via regulating Smad3 acetylation.

Kim S, Lim JH, Woo CH.

Am J Pathol. 2013 Dec;183(6):1758-68. doi: 10.1016/j.ajpath.2013.08.014. Epub 2013 Oct 1.

PMID:
24095924
11.

Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.

Avcuoglu S, Wygrecka M, Marsh LM, Günther A, Seeger W, Weissmann N, Fink L, Morty RE, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):768-80. doi: 10.1165/rcmb.2010-0195OC. Epub 2011 Feb 17.

PMID:
21330466
12.

Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.

García-Alvarez J, Ramirez R, Checa M, Nuttall RK, Sampieri CL, Edwards DR, Selman M, Pardo A.

Exp Lung Res. 2006 May;32(5):201-14.

PMID:
16908447
13.

Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Madala SK, Edukulla R, Phatak M, Schmidt S, Davidson C, Acciani TH, Korfhagen TR, Medvedovic M, Lecras TD, Wagner K, Hardie WD.

PLoS One. 2014 Jan 27;9(1):e86536. doi: 10.1371/journal.pone.0086536. eCollection 2014.

14.

Regulation of matrix contraction in chronic venous disease.

Pappas PJ, Lal BK, Ohara N, Saito S, Zapiach L, Durán WN.

Eur J Vasc Endovasc Surg. 2009 Oct;38(4):518-29. doi: 10.1016/j.ejvs.2009.05.012. Epub 2009 Jun 27.

16.

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L726-35. doi: 10.1152/ajplung.00357.2013. Epub 2014 Feb 7.

17.

Herbal formula HMC05 prevents human aortic smooth muscle cell migration and proliferation by inhibiting the ERK1/2 MAPK signaling cascade.

Kang YH, Yang IJ, Shin HM.

J Nat Med. 2012 Jan;66(1):177-84. doi: 10.1007/s11418-011-0573-3. Epub 2011 Aug 11.

PMID:
21833774
18.

Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR.

Xu X, Balsiger R, Tyrrell J, Boyaka PN, Tarran R, Cormet-Boyaka E.

Biochim Biophys Acta. 2015 Jun;1850(6):1224-32. doi: 10.1016/j.bbagen.2015.02.004. Epub 2015 Feb 16.

19.

Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on ERK1/2 MAPK activation.

Rodríguez-Barbero A, Obreo J, Alvarez-Munoz P, Pandiella A, Bernabéu C, López-Novoa JM.

Cell Physiol Biochem. 2006;18(1-3):135-42. Epub 2006 Aug 15.

20.

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