Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 67

1.

A small molecule that preferentially binds the closed conformation of Hsp90.

Alexander LD, Partridge JR, Agard DA, McAlpine SR.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7068-71. doi: 10.1016/j.bmcl.2011.09.096. Epub 2011 Sep 29.

PMID:
22014826
2.

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.

Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO.

J Biol Chem. 1997 Sep 19;272(38):23843-50.

3.

The influence of ATP and p23 on the conformation of hsp90.

Sullivan WP, Owen BA, Toft DO.

J Biol Chem. 2002 Nov 29;277(48):45942-8. Epub 2002 Sep 24.

4.

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.

Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH.

Nature. 2006 Apr 20;440(7087):1013-7.

PMID:
16625188
5.

C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle.

Weikl T, Muschler P, Richter K, Veit T, Reinstein J, Buchner J.

J Mol Biol. 2000 Nov 3;303(4):583-92.

PMID:
11054293
6.

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform.

McLaughlin SH, Ventouras LA, Lobbezoo B, Jackson SE.

J Mol Biol. 2004 Nov 26;344(3):813-26.

PMID:
15533447
7.

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.

Itoh H, Ogura M, Komatsuda A, Wakui H, Miura AB, Tashima Y.

Biochem J. 1999 Nov 1;343 Pt 3:697-703.

8.

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37).

Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH.

Cell. 2004 Jan 9;116(1):87-98.

9.

Coordinated ATP hydrolysis by the Hsp90 dimer.

Richter K, Muschler P, Hainzl O, Buchner J.

J Biol Chem. 2001 Sep 7;276(36):33689-96. Epub 2001 Jul 5.

10.

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F.

J Med Chem. 2008 Feb 14;51(3):373-5. doi: 10.1021/jm701385c. Epub 2008 Jan 16.

PMID:
18197612
11.

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.

Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ.

Nature. 2003 Sep 25;425(6956):407-10.

13.

Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain.

Garnier C, Lafitte D, Tsvetkov PO, Barbier P, Leclerc-Devin J, Millot JM, Briand C, Makarov AA, Catelli MG, Peyrot V.

J Biol Chem. 2002 Apr 5;277(14):12208-14. Epub 2002 Jan 22.

14.

Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90.

Kunicki JB, Petersen MN, Alexander LD, Ardi VC, McConnell JR, McAlpine SR.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4716-9. doi: 10.1016/j.bmcl.2011.06.083. Epub 2011 Jun 25.

15.

Assessment of the ATP binding properties of Hsp90.

Jakob U, Scheibel T, Bose S, Reinstein J, Buchner J.

J Biol Chem. 1996 Apr 26;271(17):10035-41.

16.

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.

Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ.

J Med Chem. 2005 Jun 30;48(13):4212-5.

PMID:
15974572
17.

A Grp on the Hsp90 mechanism.

Richter K, Reinstein J, Buchner J.

Mol Cell. 2007 Oct 26;28(2):177-9. Review.

18.

The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex.

Hernández MP, Sullivan WP, Toft DO.

J Biol Chem. 2002 Oct 11;277(41):38294-304. Epub 2002 Aug 2.

19.

Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

Zhang W, Hirshberg M, McLaughlin SH, Lazar GA, Grossmann JG, Nielsen PR, Sobott F, Robinson CV, Jackson SE, Laue ED.

J Mol Biol. 2004 Jul 16;340(4):891-907.

PMID:
15223329
20.

Hsp90 structure: when two ends meet.

Bracher A, Hartl FU.

Nat Struct Mol Biol. 2006 Jun;13(6):478-80. No abstract available.

PMID:
16757946

Supplemental Content

Support Center