Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 102

1.

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM.

Genes Dev. 2011 Oct 15;25(20):2158-72. doi: 10.1101/gad.16962311.

2.

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.

Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D, Barboric M.

Nucleic Acids Res. 2015 Mar 11;43(5):2575-89. doi: 10.1093/nar/gkv101. Epub 2015 Feb 20.

3.

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

Liang K, Gao X, Gilmore JM, Florens L, Washburn MP, Smith E, Shilatifard A.

Mol Cell Biol. 2015 Mar;35(6):928-38. doi: 10.1128/MCB.01426-14. Epub 2015 Jan 5.

4.

Cdk12 is essential for embryonic development and the maintenance of genomic stability.

Juan HC, Lin Y, Chen HR, Fann MJ.

Cell Death Differ. 2016 Jun;23(6):1038-48. doi: 10.1038/cdd.2015.157. Epub 2015 Dec 11.

5.

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.

Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB.

Mol Cell Biol. 2012 Nov;32(22):4691-704. doi: 10.1128/MCB.06267-11. Epub 2012 Sep 17.

6.

Structural and Functional Analysis of the Cdk13/Cyclin K Complex.

Greifenberg AK, Hönig D, Pilarova K, Düster R, Bartholomeeusen K, Bösken CA, Anand K, Blazek D, Geyer M.

Cell Rep. 2016 Jan 12;14(2):320-31. doi: 10.1016/j.celrep.2015.12.025. Epub 2015 Dec 31.

7.

The structure and substrate specificity of human Cdk12/Cyclin K.

Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blazek D, Anand K, Fisher RP, Eick D, Geyer M.

Nat Commun. 2014 Mar 24;5:3505. doi: 10.1038/ncomms4505.

8.

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL.

Genes Dev. 2010 Oct 15;24(20):2303-16. doi: 10.1101/gad.1968210.

9.

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.

Dixon-Clarke SE, Elkins JM, Cheng SW, Morin GB, Bullock AN.

Sci Rep. 2015 Nov 24;5:17122. doi: 10.1038/srep17122.

10.

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.

Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, Geyer M, Bullock AN, Young RA, Gray NS.

Nat Chem Biol. 2016 Oct;12(10):876-84. doi: 10.1038/nchembio.2166. Epub 2016 Aug 29.

11.

Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.

Bartkowiak B, Greenleaf AL.

J Biol Chem. 2015 Jan 16;290(3):1786-95. doi: 10.1074/jbc.M114.612226. Epub 2014 Nov 26.

12.

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

Chen HR, Lin GT, Huang CK, Fann MJ.

Exp Neurol. 2014 Nov;261:10-21. doi: 10.1016/j.expneurol.2014.06.024. Epub 2014 Jul 3.

13.

CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.

Chen HH, Wong YH, Geneviere AM, Fann MJ.

Biochem Biophys Res Commun. 2007 Mar 16;354(3):735-40. Epub 2007 Jan 18.

PMID:
17261272
14.
15.

[Function of CDK12 in Tumor initiation and progression and its clinical consequences].

Vrábel D, Svoboda M, Navrátil J, Kohoutek J.

Klin Onkol. 2014;27(5):340-6. Review. Czech.

PMID:
25312711
16.

P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.

Lin X, Taube R, Fujinaga K, Peterlin BM.

J Biol Chem. 2002 May 10;277(19):16873-8. Epub 2002 Mar 7.

17.

Role and therapeutic potential of CDK12 in human cancers.

Chilà R, Guffanti F, Damia G.

Cancer Treat Rev. 2016 Nov;50:83-88. doi: 10.1016/j.ctrv.2016.09.003. Epub 2016 Sep 14. Review.

PMID:
27662623
18.
19.

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.

Paculová H, Kramara J, Šimečková Š, Fedr R, Souček K, Hylse O, Paruch K, Svoboda M, Mistrík M, Kohoutek J.

Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479.

PMID:
29025359
20.

Regulation of CAK kinase activity by p53.

Schneider E, Montenarh M, Wagner P.

Oncogene. 1998 Nov 26;17(21):2733-41.

Supplemental Content

Support Center