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Items: 1 to 20 of 102

1.

Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors.

Yin Z, Craigie R.

Viruses. 2010 Dec;2(12):2777-81. doi: 10.3390/v2122777. Epub 2010 Dec 21.

2.

Structure-based modeling of the functional HIV-1 intasome and its inhibition.

Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman A.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15910-5. doi: 10.1073/pnas.1002346107. Epub 2010 Aug 23.

3.

Retroviral integrase protein and intasome nucleoprotein complex structures.

Grawenhoff J, Engelman AN.

World J Biol Chem. 2017 Feb 26;8(1):32-44. doi: 10.4331/wjbc.v8.i1.32. Review.

4.

Outer domains of integrase within retroviral intasomes are dispensible for catalysis of DNA integration.

Li M, Lin S, Craigie R.

Protein Sci. 2016 Feb;25(2):472-8. doi: 10.1002/pro.2837. Epub 2015 Nov 25.

5.

The molecular biology of HIV integrase.

Craigie R.

Future Virol. 2012 Jul;7(7):679-686.

6.

A C-terminal "Tail" Region in the Rous Sarcoma Virus Integrase Provides High Plasticity of Functional Integrase Oligomerization during Intasome Assembly.

Pandey KK, Bera S, Shi K, Aihara H, Grandgenett DP.

J Biol Chem. 2017 Mar 24;292(12):5018-5030. doi: 10.1074/jbc.M116.773382. Epub 2017 Feb 8.

PMID:
28184005
7.

Retroviral intasome assembly and inhibition of DNA strand transfer.

Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P.

Nature. 2010 Mar 11;464(7286):232-6. doi: 10.1038/nature08784. Epub 2010 Jan 31.

8.

Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration.

Yin Z, Lapkouski M, Yang W, Craigie R.

Protein Sci. 2012 Dec;21(12):1849-57. doi: 10.1002/pro.2166. Epub 2012 Oct 26.

9.

Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy.

Kotova S, Li M, Dimitriadis EK, Craigie R.

J Mol Biol. 2010 Jun 11;399(3):491-500. doi: 10.1016/j.jmb.2010.04.026. Epub 2010 Apr 21.

10.

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN.

Nature. 2016 Feb 18;530(7590):358-61. doi: 10.1038/nature16955.

11.

Crystal structure of the Rous sarcoma virus intasome.

Yin Z, Shi K, Banerjee S, Pandey KK, Bera S, Grandgenett DP, Aihara H.

Nature. 2016 Feb 18;530(7590):362-6. doi: 10.1038/nature16950.

12.

Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration.

Jones ND, Lopez MA Jr, Hanne J, Peake MB, Lee JB, Fishel R, Yoder KE.

Nat Commun. 2016 Apr 25;7:11409. doi: 10.1038/ncomms11409.

13.

Exploring the molecular mechanism of cross-resistance to HIV-1 integrase strand transfer inhibitors by molecular dynamics simulation and residue interaction network analysis.

Xue W, Jin X, Ning L, Wang M, Liu H, Yao X.

J Chem Inf Model. 2013 Jan 28;53(1):210-22. doi: 10.1021/ci300541c. Epub 2012 Dec 20.

PMID:
23231029
14.

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20057-62. doi: 10.1073/pnas.1010246107. Epub 2010 Oct 28.

15.

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR Jr, Hughes SH, Cherepanov P, Pommier Y.

ACS Chem Biol. 2013 Jan 18;8(1):209-17. doi: 10.1021/cb300471n. Epub 2012 Dec 24.

16.

Non-Enzymatic Functions of Retroviral Integrase: The Next Target for Novel Anti-HIV Drug Development.

Masuda T.

Front Microbiol. 2011 Oct 13;2:210. doi: 10.3389/fmicb.2011.00210. eCollection 2011.

17.
18.

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.

Passos DO, Li M, Yang R, Rebensburg SV, Ghirlando R, Jeon Y, Shkriabai N, Kvaratskhelia M, Craigie R, Lyumkis D.

Science. 2017 Jan 6;355(6320):89-92. doi: 10.1126/science.aah5163.

19.

Retroviral intasomes: progress and questions.

Li M, Craigie R.

Structure. 2012 Nov 7;20(11):1804-5. doi: 10.1016/j.str.2012.10.004.

20.

Study on the interactions between diketo-acid inhibitors and prototype foamy virus integrase-DNA complex via molecular docking and comparative molecular dynamics simulation methods.

Hu JP, He HQ, Tang DY, Sun GF, Zhang YQ, Fan J, Chang S.

J Biomol Struct Dyn. 2013;31(7):734-47. doi: 10.1080/07391102.2012.709458. Epub 2012 Aug 22.

PMID:
22913375

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