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Balancing calcium signals through TRPC5 and TRPC6 in podocytes.

Greka A, Mundel P.

J Am Soc Nephrol. 2011 Nov;22(11):1969-80. doi: 10.1681/ASN.2011040370. Epub 2011 Oct 6. Review.


Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.

Nijenhuis T, Sloan AJ, Hoenderop JG, Flesche J, van Goor H, Kistler AD, Bakker M, Bindels RJ, de Boer RA, Möller CC, Hamming I, Navis G, Wetzels JF, Berden JH, Reiser J, Faul C, van der Vlag J.

Am J Pathol. 2011 Oct;179(4):1719-32. doi: 10.1016/j.ajpath.2011.06.033. Epub 2011 Aug 11.


Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.

Hall G, Rowell J, Farinelli F, Gbadegesin RA, Lavin P, Wu G, Homstad A, Malone A, Lindsey T, Jiang R, Spurney R, Tomaselli GF, Kass DA, Winn MP.

Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1442-50. doi: 10.1152/ajprenal.00212.2013. Epub 2014 Apr 16.


Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes.

Chen S, He FF, Wang H, Fang Z, Shao N, Tian XJ, Liu JS, Zhu ZH, Wang YM, Wang S, Huang K, Zhang C.

Cell Calcium. 2011 Dec;50(6):523-9. doi: 10.1016/j.ceca.2011.08.008. Epub 2011 Sep 29.


Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.

Tian D, Jacobo SM, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Hsu HH, Schlondorff J, Ramos A, Greka A.

Sci Signal. 2010 Oct 26;3(145):ra77. doi: 10.1126/scisignal.2001200. Erratum in: Sci Signal. 2010;3(147):er11. Pavenstaedt, Hermann [corrected to Pavenstädt, Hermann].


Novel role of NOD2 in mediating Ca2+ signaling: evidence from NOD2-regulated podocyte TRPC6 channels in hyperhomocysteinemia.

Han H, Wang Y, Li X, Wang PA, Wei X, Liang W, Ding G, Yu X, Bao C, Zhang Y, Wang Z, Yi F.

Hypertension. 2013 Sep;62(3):506-11. doi: 10.1161/HYPERTENSIONAHA.113.01638. Epub 2013 Jul 15.


Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes.

Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, Fahlbusch M, Barth H, Smrcka A, Hildebrandt F, Gudermann T, Dietrich A.

J Cell Physiol. 2015 Jun;230(6):1389-99. doi: 10.1002/jcp.24883.


Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli.

Ilatovskaya DV, Palygin O, Chubinskiy-Nadezhdin V, Negulyaev YA, Ma R, Birnbaumer L, Staruschenko A.

Kidney Int. 2014 Sep;86(3):506-14. doi: 10.1038/ki.2014.71. Epub 2014 Mar 19.


Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.

Szabó T, Ambrus L, Zákány N, Balla G, Bíró T.

Acta Physiol Hung. 2015 Sep;102(3):241-51. doi: 10.1556/036.102.2015.3.2. Review.


ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species.

Roshanravan H, Dryer SE.

Am J Physiol Renal Physiol. 2014 May 1;306(9):F1088-97. doi: 10.1152/ajprenal.00661.2013. Epub 2014 Feb 19.


Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species.

Anderson M, Roshanravan H, Khine J, Dryer SE.

J Cell Physiol. 2014 Apr;229(4):434-42. doi: 10.1002/jcp.24461.


Over-expressing transient receptor potential cation channel 6 in podocytes induces cytoskeleton rearrangement through increases of intracellular Ca2+ and RhoA activation.

Jiang L, Ding J, Tsai H, Li L, Feng Q, Miao J, Fan Q.

Exp Biol Med (Maywood). 2011 Feb;236(2):184-93. doi: 10.1258/ebm.2010.010237.


Developmental changes in the expression and function of TRPC6 channels related the F-actin organization during differentiation in podocytes.

Liu Z, Yang J, Zhang X, Xu P, Zhang T, Yang Z.

Cell Calcium. 2015 Dec;58(6):541-8. doi: 10.1016/j.ceca.2015.09.001. Epub 2015 Sep 3.


Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.

Ambrus L, Oláh A, Oláh T, Balla G, Saleem MA, Orosz P, Zsuga J, Bíró K, Csernoch L, Bíró T, Szabó T.

J Cell Mol Med. 2015 Dec;19(12):2771-9. doi: 10.1111/jcmm.12660. Epub 2015 Sep 25.


TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.

Ilatovskaya DV, Staruschenko A.

Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F393-7. doi: 10.1152/ajprenal.00186.2015. Epub 2015 Jun 17. Review.


TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.

Zhang H, Ding J, Fan Q, Liu S.

Exp Biol Med (Maywood). 2009 Sep;234(9):1029-36. doi: 10.3181/0901-RM-11. Epub 2009 Jun 22.


Induction of TRPC6 channel in acquired forms of proteinuric kidney disease.

Möller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, Henger A, Kretzler M, Shankland SJ, Reiser J.

J Am Soc Nephrol. 2007 Jan;18(1):29-36. Epub 2006 Dec 13.


TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology.

Dryer SE, Reiser J.

Am J Physiol Renal Physiol. 2010 Oct;299(4):F689-701. doi: 10.1152/ajprenal.00298.2010. Epub 2010 Aug 4. Review.

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