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XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.

Saribasak H, Maul RW, Cao Z, McClure RL, Yang W, McNeill DR, Wilson DM 3rd, Gearhart PJ.

J Exp Med. 2011 Oct 24;208(11):2209-16. doi: 10.1084/jem.20111135.


Single-strand DNA breaks in Ig class switch recombination that depend on UNG but not AID.

Arudchandran A, Bernstein RM, Max EE.

Int Immunol. 2008 Nov;20(11):1381-93. doi: 10.1093/intimm/dxn097.


DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J.

DNA Repair (Amst). 2013 Dec;12(12):1087-93. doi: 10.1016/j.dnarep.2013.09.002.


Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.

Yousif AS, Stanlie A, Begum NA, Honjo T.

Int Immunol. 2014 Oct;26(10):575-8. doi: 10.1093/intimm/dxu071. Review.


Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.

Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1016-24. doi: 10.1073/pnas.1402391111.


Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.

Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J.

PLoS One. 2015 Aug 12;10(8):e0134397. doi: 10.1371/journal.pone.0134397.


Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination.

Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E988-97. doi: 10.1073/pnas.1320486111.


AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4.

White CA, Seth Hawkins J, Pone EJ, Yu ES, Al-Qahtani A, Mai T, Zan H, Casali P.

Autoimmunity. 2011 Dec;44(8):585-98. doi: 10.3109/08916934.2011.577128. Erratum in: Autoimmunity. 2011 Dec;44(8):664.


Controlling somatic hypermutation in immunoglobulin variable and switch regions.

Maul RW, Gearhart PJ.

Immunol Res. 2010 Jul;47(1-3):113-22. doi: 10.1007/s12026-009-8142-5. Review.


Mechanisms promoting translocations in editing and switching peripheral B cells.

Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.

Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159.


Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.

Masani S, Han L, Yu K.

Mol Cell Biol. 2013 Apr;33(7):1468-73. doi: 10.1128/MCB.00026-13.


Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination.

Cortizas EM, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM, Verdun RE.

J Immunol. 2013 Dec 1;191(11):5751-63. doi: 10.4049/jimmunol.1301300.


C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.

Sabouri S, Kobayashi M, Begum NA, Xu J, Hirota K, Honjo T.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2253-8. doi: 10.1073/pnas.1324057111.


Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.

Matthews AJ, Zheng S, DiMenna LJ, Chaudhuri J.

Adv Immunol. 2014;122:1-57. doi: 10.1016/B978-0-12-800267-4.00001-8. Review.


Parp3 negatively regulates immunoglobulin class switch recombination.

Robert I, Gaudot L, Rogier M, Heyer V, Noll A, Dantzer F, Reina-San-Martin B.

PLoS Genet. 2015 May 22;11(5):e1005240. doi: 10.1371/journal.pgen.1005240.


AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J.

J Immunol. 2011 Sep 1;187(5):2464-75. doi: 10.4049/jimmunol.1101406. Erratum in: J Immunol. 2014 May 15;192(10):4934.


The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.

Longerich S, Storb U.

Trends Genet. 2005 May;21(5):253-6. Review.


Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.

Nguyen TV, Riou L, Aoufouchi S, Rosselli F.

J Exp Med. 2014 Jun 2;211(6):1011-8. doi: 10.1084/jem.20131637.

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