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Items: 1 to 20 of 199

1.

Molecular basis for amyloid-beta polymorphism.

Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43. doi: 10.1073/pnas.1112600108. Epub 2011 Sep 23.

2.

Expression and purification of 15N- and 13C-isotope labeled 40-residue human Alzheimer's β-amyloid peptide for NMR-based structural analysis.

Long F, Cho W, Ishii Y.

Protein Expr Purif. 2011 Sep;79(1):16-24. doi: 10.1016/j.pep.2011.05.012. Epub 2011 May 27.

3.

Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution.

Rajadas J, Liu CW, Novick P, Kelley NW, Inayathullah M, Lemieux MC, Pande VS.

PLoS One. 2011;6(7):e21776. doi: 10.1371/journal.pone.0021776. Epub 2011 Jul 22.

4.

Atomic-resolution three-dimensional structure of amyloid β fibrils bearing the Osaka mutation.

Schütz AK, Vagt T, Huber M, Ovchinnikova OY, Cadalbert R, Wall J, Güntert P, Böckmann A, Glockshuber R, Meier BH.

Angew Chem Int Ed Engl. 2015 Jan 2;54(1):331-5. doi: 10.1002/anie.201408598. Epub 2014 Nov 13.

5.

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.

Sandberg A, Luheshi LM, Söllvander S, Pereira de Barros T, Macao B, Knowles TP, Biverstål H, Lendel C, Ekholm-Petterson F, Dubnovitsky A, Lannfelt L, Dobson CM, Härd T.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15595-600. doi: 10.1073/pnas.1001740107. Epub 2010 Aug 16.

6.

Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, Fändrich M, Grigorieff N.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11858-63. doi: 10.1073/pnas.1503455112. Epub 2015 Sep 8.

7.
8.

A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling.

Gu L, Tran J, Jiang L, Guo Z.

J Struct Biol. 2016 Apr;194(1):61-7. doi: 10.1016/j.jsb.2016.01.013. Epub 2016 Jan 28.

9.

DHPC strongly affects the structure and oligomerization propensity of Alzheimer's Aβ(1-40) peptide.

Dahse K, Garvey M, Kovermann M, Vogel A, Balbach J, Fändrich M, Fahr A.

J Mol Biol. 2010 Nov 5;403(4):643-59. doi: 10.1016/j.jmb.2010.09.021. Epub 2010 Sep 17.

PMID:
20851128
10.

Structural origin of polymorphism of Alzheimer's amyloid β-fibrils.

Agopian A, Guo Z.

Biochem J. 2012 Oct 1;447(1):43-50. doi: 10.1042/BJ20120034.

PMID:
22823461
11.

The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.

Younan ND, Sarell CJ, Davies P, Brown DR, Viles JH.

FASEB J. 2013 May;27(5):1847-58. doi: 10.1096/fj.12-222588. Epub 2013 Jan 18.

12.

Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.

Streltsov VA, Varghese JN, Masters CL, Nuttall SD.

J Neurosci. 2011 Jan 26;31(4):1419-26. doi: 10.1523/JNEUROSCI.4259-10.2011.

13.

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC.

Biochemistry. 2011 Sep 27;50(38):8127-37. doi: 10.1021/bi201246t. Epub 2011 Sep 1.

PMID:
21838267
14.

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R.

Science. 2005 Jan 14;307(5707):262-5.

15.

A disulfide-linked amyloid-beta peptide dimer forms a protofibril-like oligomer through a distinct pathway from amyloid fibril formation.

Yamaguchi T, Yagi H, Goto Y, Matsuzaki K, Hoshino M.

Biochemistry. 2010 Aug 24;49(33):7100-7. doi: 10.1021/bi100583x.

PMID:
20666485
16.

The Alzheimer's amyloid-β(1-42) peptide forms off-pathway oligomers and fibrils that are distinguished structurally by intermolecular organization.

Tay WM, Huang D, Rosenberry TL, Paravastu AK.

J Mol Biol. 2013 Jul 24;425(14):2494-508. doi: 10.1016/j.jmb.2013.04.003. Epub 2013 Apr 11.

PMID:
23583777
17.

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R.

J Phys Chem B. 2012 Feb 9;116(5):1728-35. doi: 10.1021/jp2108126. Epub 2012 Jan 25.

18.

The heterogeneous nature of Cu2+ interactions with Alzheimer's amyloid-β peptide.

Drew SC, Barnham KJ.

Acc Chem Res. 2011 Nov 15;44(11):1146-55. doi: 10.1021/ar200014u. Epub 2011 Jun 29.

PMID:
21714485
20.

Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics.

Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D.

J Am Chem Soc. 2011 May 4;133(17):6736-44. doi: 10.1021/ja200222n. Epub 2011 Apr 7.

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