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Items: 1 to 20 of 1210

1.

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA.

Breast Cancer Res. 2011 Sep 17;13(5):R89. doi: 10.1186/bcr2946.

2.

Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

Peng M, Ball-Kell SM, Tyner AL.

Cell Death Dis. 2015 Aug 6;6:e1848. doi: 10.1038/cddis.2015.210.

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Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA.

Cancer Res. 2013 Sep 15;73(18):5810-20. doi: 10.1158/0008-5472.CAN-13-0523. Epub 2013 Aug 8. Erratum in: Cancer Res. 2013 Nov 1;73(21):6538.

6.

Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions.

Leung K, Nagy A, Gonzalez-Gomez I, Groffen J, Heisterkamp N, Kaartinen V.

Cells Tissues Organs. 2003;175(2):72-83.

PMID:
14605486
7.

Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.

Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, Kenney N, Wechselberger C, Callahan R, Salomon DS.

Am J Pathol. 2005 Aug;167(2):585-97.

8.

Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.

Ai M, Liang K, Lu Y, Qiu S, Fan Z.

Cancer Biol Ther. 2013 Mar;14(3):237-45. doi: 10.4161/cbt.23295. Epub 2013 Jan 4.

9.

Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.

Ludyga N, Anastasov N, Gonzalez-Vasconcellos I, Ram M, Höfler H, Aubele M.

Mol Biosyst. 2011 May;7(5):1603-12. doi: 10.1039/c0mb00286k. Epub 2011 Mar 4.

PMID:
21380407
10.

p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.

Cabodi S, Tinnirello A, Di Stefano P, Bisarò B, Ambrosino E, Castellano I, Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F, Turco E, Tarone G, Defilippi P.

Cancer Res. 2006 May 1;66(9):4672-80.

11.

PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.

Park SH, Ito K, Olcott W, Katsyv I, Halstead-Nussloch G, Irie HY.

Breast Cancer Res. 2015 Jun 19;17:86. doi: 10.1186/s13058-015-0594-z.

12.

Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.

Gierut J, Zheng Y, Bie W, Carroll RE, Ball-Kell S, Haegebarth A, Tyner AL.

Gastroenterology. 2011 Oct;141(4):1371-80, 1380.e1-2. doi: 10.1053/j.gastro.2011.06.071. Epub 2011 Jul 8.

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p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis.

Yallowitz AR, Alexandrova EM, Talos F, Xu S, Marchenko ND, Moll UM.

Cell Death Differ. 2014 Apr;21(4):645-54. doi: 10.1038/cdd.2013.199. Epub 2014 Jan 17.

15.

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Peng M, Emmadi R, Wang Z, Wiley EL, Gann PH, Khan SA, Banerji N, McDonald W, Asztalos S, Pham TN, Tonetti DA, Tyner AL.

Oncotarget. 2014 Aug 15;5(15):6038-48.

16.

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.

Sum EY, Segara D, Duscio B, Bath ML, Field AS, Sutherland RL, Lindeman GJ, Visvader JE.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7659-64. Epub 2005 May 16.

18.

Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.

Bray K, Gillette M, Young J, Loughran E, Hwang M, Sears JC, Vargo-Gogola T.

Breast Cancer Res. 2013;15(5):R91.

20.

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2013 Sep 5;32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.

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