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Items: 1 to 20 of 159


Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type.

Summermatter S, Thurnheer R, Santos G, Mosca B, Baum O, Treves S, Hoppeler H, Zorzato F, Handschin C.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C88-99. doi: 10.1152/ajpcell.00190.2011. Epub 2011 Sep 14.


The effects of PGC-1α on control of microvascular P(O2) kinetics following onset of muscle contractions.

Kano Y, Miura S, Eshima H, Ezaki O, Poole DC.

J Appl Physiol (1985). 2014 Jul 15;117(2):163-70. doi: 10.1152/japplphysiol.00080.2014. Epub 2014 May 15.


Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse.

Selsby JT, Morine KJ, Pendrak K, Barton ER, Sweeney HL.

PLoS One. 2012;7(1):e30063. doi: 10.1371/journal.pone.0030063. Epub 2012 Jan 11.


Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation.

Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp JB, Yamamoto M, Noguchi CT.

Int J Biochem Cell Biol. 2013 Jul;45(7):1155-64. doi: 10.1016/j.biocel.2013.03.007. Epub 2013 Mar 20.


Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.

Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z.

J Biol Chem. 2005 May 20;280(20):19587-93. Epub 2005 Mar 14.


PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.

Geng T, Li P, Okutsu M, Yin X, Kwek J, Zhang M, Yan Z.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C572-9. doi: 10.1152/ajpcell.00481.2009. Epub 2009 Dec 23.


TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure.

Tang K, Wagner PD, Breen EC.

J Cell Physiol. 2010 Feb;222(2):320-7. doi: 10.1002/jcp.21955.


Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.

Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM.

J Biol Chem. 2007 Oct 12;282(41):30014-21. Epub 2007 Aug 16.


Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.

Summermatter S, Baum O, Santos G, Hoppeler H, Handschin C.

J Biol Chem. 2010 Oct 22;285(43):32793-800. doi: 10.1074/jbc.M110.145995. Epub 2010 Aug 17.


[The regulation effect of PGC-1alpha on skeletal muscle fiber type and exercise performance].

Yu L, Zhang P, Wang RY.

Sheng Li Ke Xue Jin Zhan. 2013 Feb;44(1):59-62. Review. Chinese. No abstract available.


Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice.

Akimoto T, Sorg BS, Yan Z.

Am J Physiol Cell Physiol. 2004 Sep;287(3):C790-6. Epub 2004 May 19.


PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations.

Irrcher I, Adhihetty PJ, Sheehan T, Joseph AM, Hood DA.

Am J Physiol Cell Physiol. 2003 Jun;284(6):C1669-77.


Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice.

Bruton JD, Aydin J, Yamada T, Shabalina IG, Ivarsson N, Zhang SJ, Wada M, Tavi P, Nedergaard J, Katz A, Westerblad H.

J Physiol. 2010 Nov 1;588(Pt 21):4275-88. doi: 10.1113/jphysiol.2010.198598.


Inverse regulation of the cytosolic Ca²⁺ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axis.

Ducreux S, Gregory P, Schwaller B.

PLoS One. 2012;7(9):e44837. doi: 10.1371/journal.pone.0044837. Epub 2012 Sep 13.


MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle.

Wada S, Kato Y, Sawada S, Aizawa K, Park JH, Russell AP, Ushida T, Akimoto T.

Pflugers Arch. 2015 Feb;467(2):389-98. doi: 10.1007/s00424-014-1517-z. Epub 2014 Apr 23.


G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.

Chen M, Feng HZ, Gupta D, Kelleher J, Dickerson KE, Wang J, Hunt D, Jou W, Gavrilova O, Jin JP, Weinstein LS.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C930-40. doi: 10.1152/ajpcell.00443.2008. Epub 2009 Jan 21.


Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise.

Wallace MA, Hock MB, Hazen BC, Kralli A, Snow RJ, Russell AP.

J Physiol. 2011 Apr 15;589(Pt 8):2027-39. doi: 10.1113/jphysiol.2011.205468. Epub 2011 Feb 21.


Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.

Martínez-Redondo V, Jannig PR, Correia JC, Ferreira DM, Cervenka I, Lindvall JM, Sinha I, Izadi M, Pettersson-Klein AT, Agudelo LZ, Gimenez-Cassina A, Brum PC, Dahlman-Wright K, Ruas JL.

J Biol Chem. 2016 Jul 15;291(29):15169-84. doi: 10.1074/jbc.M115.705822. Epub 2016 May 26.


PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.

Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16260-5. Epub 2006 Oct 19.


PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.

Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21866-71. doi: 10.1073/pnas.1016089107. Epub 2010 Nov 24.

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