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Items: 1 to 20 of 105

1.

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U.

J Biol Chem. 2011 Dec 2;286(48):41616-25. doi: 10.1074/jbc.M111.283689. Epub 2011 Sep 13.

2.

KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells.

Berry WL, Janknecht R.

Cancer Res. 2013 May 15;73(10):2936-42. doi: 10.1158/0008-5472.CAN-12-4300. Epub 2013 May 3. Review.

3.

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A.

PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535.

4.

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates.

Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A.

Epigenetics. 2014 Dec;9(12):1596-603. doi: 10.4161/15592294.2014.983381.

5.

Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice.

Chen Q, Chen X, Wang Q, Zhang F, Lou Z, Zhang Q, Zhou DX.

PLoS Genet. 2013;9(1):e1003239. doi: 10.1371/journal.pgen.1003239. Epub 2013 Jan 24.

6.

Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.

Goda S, Isagawa T, Chikaoka Y, Kawamura T, Aburatani H.

J Biol Chem. 2013 Dec 27;288(52):36948-56. doi: 10.1074/jbc.M113.492595. Epub 2013 Nov 8.

7.

KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.

Chin YW, Han SY.

Expert Opin Ther Pat. 2015 Feb;25(2):135-44. doi: 10.1517/13543776.2014.991310. Epub 2014 Dec 3. Review.

PMID:
25468267
8.

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.

Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC.

J Med Chem. 2014 Jul 24;57(14):5975-85. doi: 10.1021/jm500249n. Epub 2014 Jul 9.

9.

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues.

Langley GW, Brinkø A, Münzel M, Walport LJ, Schofield CJ, Hopkinson RJ.

ACS Chem Biol. 2016 Mar 18;11(3):755-62. doi: 10.1021/acschembio.5b00738. Epub 2015 Nov 25.

PMID:
26555343
10.

How substrate specificity is imposed on a histone demethylase--lessons from KDM2A.

Tsai CL, Shi Y, Tainer JA.

Genes Dev. 2014 Aug 15;28(16):1735-8. doi: 10.1101/gad.249755.114.

11.

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.

Agger K, Miyagi S, Pedersen MT, Kooistra SM, Johansen JV, Helin K.

Genes Dev. 2016 Jun 1;30(11):1278-88. doi: 10.1101/gad.280495.116. Epub 2016 Jun 2.

12.

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U.

Nature. 2007 Jul 5;448(7149):87-91. Epub 2007 Jun 24.

PMID:
17589501
13.

The Jumonji gene family in Crassostrea gigas suggests evolutionary conservation of Jmj-C histone demethylases orthologues in the oyster gametogenesis and development.

Fellous A, Favrel P, Guo X, Riviere G.

Gene. 2014 Mar 15;538(1):164-75. doi: 10.1016/j.gene.2013.12.016. Epub 2014 Jan 6.

PMID:
24406622
14.

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

Yue WW, Hozjan V, Ge W, Loenarz C, Cooper CD, Schofield CJ, Kavanagh KL, Oppermann U, McDonough MA.

FEBS Lett. 2010 Feb 19;584(4):825-30. doi: 10.1016/j.febslet.2009.12.055. Epub 2010 Jan 12.

15.

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

Cheng Z, Cheung P, Kuo AJ, Yukl ET, Wilmot CM, Gozani O, Patel DJ.

Genes Dev. 2014 Aug 15;28(16):1758-71. doi: 10.1101/gad.246561.114.

16.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Diallo H, Douault C, Drewes G, Eagle R, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Liddle J, Mosley J, Muelbaier M, Randle R, Rioja I, Rueger A, Seal GA, Sheppard RJ, Singh O, Taylor J, Thomas P, Thomson D, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1357-69. doi: 10.1021/acs.jmedchem.5b01537. Epub 2016 Jan 15.

PMID:
26771107
17.

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.

Kristensen LH, Nielsen AL, Helgstrand C, Lees M, Cloos P, Kastrup JS, Helin K, Olsen L, Gajhede M.

FEBS J. 2012 Jun;279(11):1905-14. doi: 10.1111/j.1742-4658.2012.08567.x. Epub 2012 May 2.

18.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Drewes G, Eagle R, Garton N, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Pemberton M, Rioja I, Seal GA, Shipley T, Singh O, Suckling CJ, Taylor J, Thomas P, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1370-87. doi: 10.1021/acs.jmedchem.5b01538. Epub 2016 Jan 15.

PMID:
26771203
19.

Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases.

Krishnan S, Trievel RC.

Structure. 2013 Jan 8;21(1):98-108. doi: 10.1016/j.str.2012.10.018. Epub 2012 Dec 6.

20.

Studies on substrate specificity of Jmjd2a-c histone demethylases.

Ponnaluri VK, Vavilala DT, Mukherji M.

Biochem Biophys Res Commun. 2011 Feb 25;405(4):588-92. doi: 10.1016/j.bbrc.2011.01.073. Epub 2011 Jan 23.

PMID:
21266164

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