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Items: 1 to 20 of 105


Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.

Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE.

Genes Dev. 2011 Sep 1;25(17):1835-46. doi: 10.1101/gad.17175111.


Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.

Buchberger JR, Onishi M, Li G, Seebacher J, Rudner AD, Gygi SP, Moazed D.

Mol Cell Biol. 2008 Nov;28(22):6903-18. doi: 10.1128/MCB.01210-08. Epub 2008 Sep 15.


Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.

Connelly JJ, Yuan P, Hsu HC, Li Z, Xu RM, Sternglanz R.

Mol Cell Biol. 2006 Apr;26(8):3256-65.


Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.

van Welsem T, Frederiks F, Verzijlbergen KF, Faber AW, Nelson ZW, Egan DA, Gottschling DE, van Leeuwen F.

Mol Cell Biol. 2008 Jun;28(11):3861-72. doi: 10.1128/MCB.02050-07. Epub 2008 Apr 7.


A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.

Rudner AD, Hall BE, Ellenberger T, Moazed D.

Mol Cell Biol. 2005 Jun;25(11):4514-28.


Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution.

Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE.

Science. 2011 Nov 18;334(6058):977-82. doi: 10.1126/science.1210915.


Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly.

Onishi M, Liou GG, Buchberger JR, Walz T, Moazed D.

Mol Cell. 2007 Dec 28;28(6):1015-28.


Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA.

Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8495-500. doi: 10.1073/pnas.1300126110. Epub 2013 May 6.


Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin.

Liaw H, Lustig AJ.

Mol Cell Biol. 2006 Oct;26(20):7616-31. Epub 2006 Aug 14.


Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3.

Chang JF, Hall BE, Tanny JC, Moazed D, Filman D, Ellenberger T.

Structure. 2003 Jun;11(6):637-49. Erratum in: Structure (Camb). 2004 Aug;12(8):1547.


Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.

Sampath V, Yuan P, Wang IX, Prugar E, van Leeuwen F, Sternglanz R.

Mol Cell Biol. 2009 May;29(10):2532-45. doi: 10.1128/MCB.01682-08. Epub 2009 Mar 9.


Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae.

Samel A, Rudner A, Ehrenhofer-Murray AE.

G3 (Bethesda). 2017 Apr 3;7(4):1117-1126. doi: 10.1534/g3.116.037739.


Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interaction.

Norris A, Bianchet MA, Boeke JD.

PLoS Genet. 2008 Dec;4(12):e1000301. doi: 10.1371/journal.pgen.1000301. Epub 2008 Dec 12.


Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation.

Oppikofer M, Kueng S, Keusch JJ, Hassler M, Ladurner AG, Gut H, Gasser SM.

EMBO J. 2013 Feb 6;32(3):437-49. doi: 10.1038/emboj.2012.343. Epub 2013 Jan 8.


Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.

Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP, Moazed D.

Mol Cell Biol. 2002 Jun;22(12):4167-80.


Sir Antagonist 1 (San1) is a ubiquitin ligase.

Dasgupta A, Ramsey KL, Smith JS, Auble DT.

J Biol Chem. 2004 Jun 25;279(26):26830-8. Epub 2004 Apr 12.


Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.

Yang D, Fang Q, Wang M, Ren R, Wang H, He M, Sun Y, Yang N, Xu RM.

Nat Struct Mol Biol. 2013 Sep;20(9):1116-8. doi: 10.1038/nsmb.2637. Epub 2013 Aug 11.


Transcriptional silencing functions of the yeast protein Orc1/Sir3 subfunctionalized after gene duplication.

Hickman MA, Rusche LN.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19384-9. doi: 10.1073/pnas.1006436107. Epub 2010 Oct 25.


A model for step-wise assembly of heterochromatin in yeast.

Moazed D, Rudner AD, Huang J, Hoppe GJ, Tanny JC.

Novartis Found Symp. 2004;259:48-56; discussion 56-62, 163-9. Review.


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