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Items: 1 to 20 of 148


Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage.

Foster SS, Balestrini A, Petrini JH.

Mol Cell Biol. 2011 Nov;31(21):4379-89. doi: 10.1128/MCB.05854-11. Epub 2011 Aug 29.


Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2.

Mimitou EP, Symington LS.

EMBO J. 2010 Oct 6;29(19):3358-69. doi: 10.1038/emboj.2010.193. Epub 2010 Aug 20.


Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease.

Westmoreland JW, Resnick MA.

PLoS Genet. 2013 Mar;9(3):e1003420. doi: 10.1371/journal.pgen.1003420. Epub 2013 Mar 28.


Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.

Ferrari M, Dibitetto D, De Gregorio G, Eapen VV, Rawal CC, Lazzaro F, Tsabar M, Marini F, Haber JE, Pellicioli A.

PLoS Genet. 2015 Jan 8;11(1):e1004928. doi: 10.1371/journal.pgen.1004928. eCollection 2015 Jan.


Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.

Chen H, Donnianni RA, Handa N, Deng SK, Oh J, Timashev LA, Kowalczykowski SC, Symington LS.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1880-7. doi: 10.1073/pnas.1503331112. Epub 2015 Mar 23.


Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

Muñoz-Galván S, López-Saavedra A, Jackson SP, Huertas P, Cortés-Ledesma F, Aguilera A.

Nucleic Acids Res. 2013 Feb 1;41(3):1669-83. doi: 10.1093/nar/gks1274. Epub 2012 Dec 18.


The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends.

Bonetti D, Clerici M, Manfrini N, Lucchini G, Longhese MP.

PLoS One. 2010 Nov 30;5(11):e14142. doi: 10.1371/journal.pone.0014142.


Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.

Arora S, Deshpande RA, Budd M, Campbell J, Revere A, Zhang X, Schmidt KH, Paull TT.

Mol Cell Biol. 2017 Nov 28;37(24). pii: e00156-17. doi: 10.1128/MCB.00156-17. Print 2017 Dec 15.


Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.


Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P, Mejia-Ramirez E, Limbo O, Russell P.

PLoS Genet. 2011 Sep;7(9):e1002271. doi: 10.1371/journal.pgen.1002271. Epub 2011 Sep 8.


S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.

Chen YJ, Chuang YC, Chuang CN, Cheng YH, Chang CR, Leng CH, Wang TF.

Nucleic Acids Res. 2016 Mar 18;44(5):2199-213. doi: 10.1093/nar/gkv1523. Epub 2016 Jan 6.


Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.

Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE.

EMBO J. 2010 Oct 6;29(19):3370-80. doi: 10.1038/emboj.2010.219. Epub 2010 Sep 10.


Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex.

Oh J, Al-Zain A, Cannavo E, Cejka P, Symington LS.

Mol Cell. 2016 Oct 20;64(2):405-415. doi: 10.1016/j.molcel.2016.09.011. Epub 2016 Oct 13.


Synthetic viability genomic screening defines Sae2 function in DNA repair.

Puddu F, Oelschlaegel T, Guerini I, Geisler NJ, Niu H, Herzog M, Salguero I, Ochoa-Montaño B, Viré E, Sung P, Adams DJ, Keane TM, Jackson SP.

EMBO J. 2015 Jun 3;34(11):1509-22. doi: 10.15252/embj.201590973. Epub 2015 Apr 21.


Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.

Lewis LK, Storici F, Van Komen S, Calero S, Sung P, Resnick MA.

Genetics. 2004 Apr;166(4):1701-13.


Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection.

Krasner DS, Daley JM, Sung P, Niu H.

J Biol Chem. 2015 Jul 24;290(30):18806-16. doi: 10.1074/jbc.M115.660191. Epub 2015 Jun 11.

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