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Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells.

Abbott RD, Purmessur D, Monsey RD, Iatridis JC.

J Orthop Res. 2012 Mar;30(3):482-8. doi: 10.1002/jor.21534. Epub 2011 Aug 22.


Degenerative grade affects the responses of human nucleus pulposus cells to link-N, CTGF, and TGFβ3.

Abbott RD, Purmessur D, Monsey RD, Brigstock DR, Laudier DM, Iatridis JC.

J Spinal Disord Tech. 2013 May;26(3):E86-94. doi: 10.1097/BSD.0b013e31826e0ca4.


Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype.

Korecki CL, Taboas JM, Tuan RS, Iatridis JC.

Stem Cell Res Ther. 2010 Jun 16;1(2):18. doi: 10.1186/scrt18.


Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells.

Purmessur D, Schek RM, Abbott RD, Ballif BA, Godburn KE, Iatridis JC.

Arthritis Res Ther. 2011 May 31;13(3):R81. doi: 10.1186/ar3344.


The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs.

Bach FC, de Vries SA, Krouwels A, Creemers LB, Ito K, Meij BP, Tryfonidou MA.

Eur Cell Mater. 2015 Sep 21;30:132-46; discussion 146-7.


Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability.

Purmessur D, Cornejo MC, Cho SK, Roughley PJ, Linhardt RJ, Hecht AC, Iatridis JC.

Spine J. 2015 May 1;15(5):1060-9. doi: 10.1016/j.spinee.2015.02.003. Epub 2015 Feb 7.


Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia.

Gantenbein B, Calandriello E, Wuertz-Kozak K, Benneker LM, Keel MJ, Chan SC.

BMC Musculoskelet Disord. 2014 Dec 11;15:422. doi: 10.1186/1471-2474-15-422.


Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration.

Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FW.

Arthritis Res Ther. 2011;13(6):R215. doi: 10.1186/ar3548. Epub 2011 Dec 29.


Increased osmolarity and cell clustering preserve canine notochordal cell phenotype in culture.

Spillekom S, Smolders LA, Grinwis GC, Arkesteijn IT, Ito K, Meij BP, Tryfonidou MA.

Tissue Eng Part C Methods. 2014 Aug;20(8):652-62. doi: 10.1089/ten.TEC.2013.0479. Epub 2014 Feb 14.


Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells.

de Vries SA, Potier E, van Doeselaar M, Meij BP, Tryfonidou MA, Ito K.

Tissue Eng Part A. 2015 Mar;21(5-6):1077-84. doi: 10.1089/ten.TEA.2014.0309. Epub 2014 Dec 17.


Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration.

Arkesteijn IT, Smolders LA, Spillekom S, Riemers FM, Potier E, Meij BP, Ito K, Tryfonidou MA.

Arthritis Res Ther. 2015 Mar 14;17:60. doi: 10.1186/s13075-015-0569-6.


Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine intervertebral disc organ culture model.

Furtwängler T, Chan SC, Bahrenberg G, Richards PJ, Gantenbein-Ritter B.

Spine (Phila Pa 1976). 2013 Oct 15;38(22):E1377-87. doi: 10.1097/BRS.0b013e31829ffde8.


[Transplantation of transforming growth factor beta3 gene-modified nucleus pulposus cells for intervertebral disc degeneration in rabbits].

Song X, Peng S.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Jul;26(7):790-5. Chinese.


Native nucleus pulposus tissue matrix promotes notochordal differentiation of human induced pluripotent stem cells with potential for treating intervertebral disc degeneration.

Liu Y, Fu S, Rahaman MN, Mao JJ, Bal BS.

J Biomed Mater Res A. 2015 Mar;103(3):1053-9. doi: 10.1002/jbm.a.35243. Epub 2014 Jun 17.


The Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture.

de Vries SA, van Doeselaar M, Meij BP, Tryfonidou MA, Ito K.

Tissue Eng Part A. 2016 Jan;22(1-2):103-10. doi: 10.1089/ten.TEA.2015.0121. Epub 2015 Nov 5.


Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.

Illien-Jünger S, Lu Y, Purmessur D, Mayer JE, Walter BA, Roughley PJ, Qureshi SA, Hecht AC, Iatridis JC.

Spine J. 2014 Nov 1;14(11):2724-32. doi: 10.1016/j.spinee.2014.04.017. Epub 2014 Apr 24.


Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc.

Boyd LM, Chen J, Kraus VB, Setton LA.

Spine (Phila Pa 1976). 2004 Oct 15;29(20):2217-22.


Increased caveolin-1 in intervertebral disc degeneration facilitates repair.

Bach FC, Zhang Y, Miranda-Bedate A, Verdonschot LC, Bergknut N, Creemers LB, Ito K, Sakai D, Chan D, Meij BP, Tryfonidou MA.

Arthritis Res Ther. 2016 Mar 3;18:59. doi: 10.1186/s13075-016-0960-y.


Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration.

Smolders LA, Meij BP, Riemers FM, Licht R, Wubbolts R, Heuvel D, Grinwis GC, Vernooij HC, Hazewinkel HA, Penning LC, Tryfonidou MA.

J Orthop Res. 2012 Jun;30(6):950-7. doi: 10.1002/jor.22000. Epub 2011 Nov 14.


Rheological and biological properties of a hydrogel support for cells intended for intervertebral disc repair.

Benz K, Stippich C, Osswald C, Gaissmaier C, Lembert N, Badke A, Steck E, Aicher WK, Mollenhauer JA.

BMC Musculoskelet Disord. 2012 Apr 10;13:54. doi: 10.1186/1471-2474-13-54.

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