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7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription.

Peterlin BM, Brogie JE, Price DH.

Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):92-103. doi: 10.1002/wrna.106. Epub 2011 Aug 18.


Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015. Epub 2014 Feb 10.


RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.

Muniz L, Egloff S, Kiss T.

Nucleic Acids Res. 2013 Apr;41(8):4686-98. doi: 10.1093/nar/gkt159. Epub 2013 Mar 6.


7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor.

Diribarne G, Bensaude O.

RNA Biol. 2009 Apr-Jun;6(2):122-8. Epub 2009 Apr 6. Review.


The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.

Krueger BJ, Varzavand K, Cooper JJ, Price DH.

PLoS One. 2010 Aug 23;5(8):e12335. doi: 10.1371/journal.pone.0012335.


Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.

Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q.

Mol Cell. 2003 Oct;12(4):971-82.


Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

Muniz L, Egloff S, Ughy B, Jády BE, Kiss T.

PLoS Pathog. 2010 Oct 14;6(10):e1001152. doi: 10.1371/journal.ppat.1001152.


LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.

Krueger BJ, Jeronimo C, Roy BB, Bouchard A, Barrandon C, Byers SA, Searcey CE, Cooper JJ, Bensaude O, Cohen EA, Coulombe B, Price DH.

Nucleic Acids Res. 2008 Apr;36(7):2219-29. doi: 10.1093/nar/gkn061. Epub 2008 Feb 16.


Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.

J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746. Epub 2012 Sep 5. Erratum in: J Biol Chem. 2013 Apr 26;288(17):12214.


The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes.

Barrandon C, Bonnet F, Nguyen VT, Labas V, Bensaude O.

Mol Cell Biol. 2007 Oct;27(20):6996-7006. Epub 2007 Aug 20.


Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb.

Van Herreweghe E, Egloff S, Goiffon I, Jády BE, Froment C, Monsarrat B, Kiss T.

EMBO J. 2007 Aug 8;26(15):3570-80. Epub 2007 Jul 5.


A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.

Xue Y, Yang Z, Chen R, Zhou Q.

Nucleic Acids Res. 2010 Jan;38(2):360-9. doi: 10.1093/nar/gkp977. Epub 2009 Nov 11.


The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.

Egloff S, Vitali P, Tellier M, Raffel R, Murphy S, Kiss T.

EMBO J. 2017 Apr 3;36(7):934-948. doi: 10.15252/embj.201695740. Epub 2017 Mar 2.


PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.

Gudipaty SA, McNamara RP, Morton EL, D'Orso I.

Mol Cell Biol. 2015 Nov;35(22):3810-28. doi: 10.1128/MCB.00226-15. Epub 2015 Aug 31.


Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.

Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.

EMBO J. 2005 Dec 21;24(24):4291-303. Epub 2005 Dec 15.


7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells.

Abasi M, Bazi Z, Mohammadi-Yeganeh S, Soleimani M, Haghpanah V, Zargami N, Ghanbarian H.

Med Oncol. 2016 Nov;33(11):128. Epub 2016 Oct 17.


LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.

Ji X, Lu H, Zhou Q, Luo K.

Elife. 2014 Jul 22;3:e02907. doi: 10.7554/eLife.02907.


HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.

Byers SA, Price JP, Cooper JJ, Li Q, Price DH.

J Biol Chem. 2005 Apr 22;280(16):16360-7. Epub 2005 Feb 14.

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