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Items: 1 to 20 of 113


The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.

Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW.

Structure. 2011 Aug 10;19(8):1084-96. doi: 10.1016/j.str.2011.07.001.


Apoptosome structure, assembly, and procaspase activation.

Yuan S, Akey CW.

Structure. 2013 Apr 2;21(4):501-15. doi: 10.1016/j.str.2013.02.024. Review.


Changes in Apaf-1 conformation that drive apoptosome assembly.

Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW.

Biochemistry. 2013 Apr 2;52(13):2319-27. doi: 10.1021/bi301721g. Epub 2013 Mar 22.


Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome.

Su TW, Yang CY, Kao WP, Kuo BJ, Lin SM, Lin JY, Lo YC, Lin SC.

Structure. 2017 Mar 7;25(3):407-420. doi: 10.1016/j.str.2016.12.019. Epub 2017 Jan 19.


A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation.

Würstle ML, Rehm M.

J Biol Chem. 2014 Sep 19;289(38):26277-89. doi: 10.1074/jbc.M114.590034. Epub 2014 Aug 8.


Understanding CARD Tricks in Apoptosomes.

Wang L, Qiao Q, Wu H.

Structure. 2017 Apr 4;25(4):575-577. doi: 10.1016/j.str.2017.03.013.


A near atomic structure of the active human apoptosome.

Cheng TC, Hong C, Akey IV, Yuan S, Akey CW.

Elife. 2016 Oct 4;5. pii: e17755. doi: 10.7554/eLife.17755.


Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9.

Hu Q, Wu D, Chen W, Yan Z, Shi Y.

J Biol Chem. 2013 May 24;288(21):15142-7. doi: 10.1074/jbc.M112.441568. Epub 2013 Apr 9.


Structure of an apoptosome-procaspase-9 CARD complex.

Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW.

Structure. 2010 May 12;18(5):571-83. doi: 10.1016/j.str.2010.04.001.


The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.

Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB.

EMBO J. 2009 Jul 8;28(13):1916-25. doi: 10.1038/emboj.2009.152. Epub 2009 Jun 4.


Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP.

Zou H, Yang R, Hao J, Wang J, Sun C, Fesik SW, Wu JC, Tomaselli KJ, Armstrong RC.

J Biol Chem. 2003 Mar 7;278(10):8091-8. Epub 2002 Dec 27.


Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.

Hu Q, Wu D, Chen W, Yan Z, Yan C, He T, Liang Q, Shi Y.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16254-61. doi: 10.1073/pnas.1418000111. Epub 2014 Oct 13.


Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway.

Sharoar MG, Islam MI, Shahnawaz M, Shin SY, Park IS.

Biochim Biophys Acta. 2014 Apr;1843(4):685-93. doi: 10.1016/j.bbamcr.2014.01.008. Epub 2014 Jan 12.


Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.

Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K.

J Biol Chem. 2004 May 7;279(19):19665-82. Epub 2004 Mar 1.


A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome.

Reubold TF, Wohlgemuth S, Eschenburg S.

J Biol Chem. 2009 Nov 20;284(47):32717-24. doi: 10.1074/jbc.M109.014027. Epub 2009 Sep 30.


A molecular view on signal transduction by the apoptosome.

Reubold TF, Eschenburg S.

Cell Signal. 2012 Jul;24(7):1420-5. doi: 10.1016/j.cellsig.2012.03.007. Epub 2012 Mar 13. Review.


Structure of the Drosophila apoptosome at 6.9 å resolution.

Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW.

Structure. 2011 Jan 12;19(1):128-40. doi: 10.1016/j.str.2010.10.009.


Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.

Pang Y, Bai XC, Yan C, Hao Q, Chen Z, Wang JW, Scheres SH, Shi Y.

Genes Dev. 2015 Feb 1;29(3):277-87. doi: 10.1101/gad.255877.114.


Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1.

Zhou M, Li Y, Hu Q, Bai XC, Huang W, Yan C, Scheres SH, Shi Y.

Genes Dev. 2015 Nov 15;29(22):2349-61. doi: 10.1101/gad.272278.115. Epub 2015 Nov 5.


Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.

Bao Q, Lu W, Rabinowitz JD, Shi Y.

Mol Cell. 2007 Jan 26;25(2):181-92.

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