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Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury.

Fabisiak JP, Medvedovic M, Alexander DC, McDunn JE, Concel VJ, Bein K, Jang AS, Berndt A, Vuga LJ, Brant KA, Pope-Varsalona H, Dopico RA Jr, Ganguly K, Upadhyay S, Li Q, Hu Z, Kaminski N, Leikauf GD.

Mol Nutr Food Res. 2011 Sep;55(9):1423-34. doi: 10.1002/mnfr.201100291. Epub 2011 Aug 8.


Integrative assessment of chlorine-induced acute lung injury in mice.

Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):234-44. doi: 10.1165/rcmb.2012-0026OC. Epub 2012 Mar 23.


Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury.

Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Dopico RA Jr, Di YP, Knoell DL, Barchowsky A, Leikauf GD.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):483-90. doi: 10.1165/rcmb.2009-0391OC. Epub 2010 Jun 4.


Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke.

Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1586-97. doi: 10.1152/ajpheart.00867.2008. Epub 2009 Mar 6.


Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein.

Conklin DJ, Haberzettl P, Jagatheesan G, Kong M, Hoyle GW.

Toxicol Appl Pharmacol. 2017 Jun 1;324:61-72. doi: 10.1016/j.taap.2016.08.028. Epub 2016 Aug 31.


Acrolein - a pulmonary hazard.

Bein K, Leikauf GD.

Mol Nutr Food Res. 2011 Sep;55(9):1342-60. doi: 10.1002/mnfr.201100279. Review.


Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34.

Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K.

Oxid Med Cell Longev. 2015;2015:170309. doi: 10.1155/2015/170309. Epub 2015 Mar 3.


Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA, Dietsch M, Pope-Varsalona H, Dopico RA Jr, Di YP, Li Q, Vuga LJ, Medvedovic M, Kaminski N, You M, Prows DR.

Am J Respir Crit Care Med. 2011 Jun 1;183(11):1499-509. doi: 10.1164/rccm.201006-0912OC. Epub 2011 Feb 4.


Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology.

Borchers MT, Wesselkamper SC, Eppert BL, Motz GT, Sartor MA, Tomlinson CR, Medvedovic M, Tichelaar JW.

Toxicol Sci. 2008 Sep;105(1):188-99. doi: 10.1093/toxsci/kfn106. Epub 2008 May 29.


Metabolic shift in lung alveolar cell mitochondria following acrolein exposure.

Agarwal AR, Yin F, Cadenas E.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L764-73. doi: 10.1152/ajplung.00165.2013. Epub 2013 Sep 20.


The role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell pathology.

Borchers MT, Wesselkamper SC, Deshmukh H, Beckman E, Medvedovic M, Sartor M, Leikauf GD; HEI Health Review Committee.

Res Rep Health Eff Inst. 2009 Dec;(146):5-29.


Proteomic profiling of rat lung epithelial cells induced by acrolein.

Sarkar P, Hayes BE.

Life Sci. 2009 Jul 31;85(5-6):188-95. doi: 10.1016/j.lfs.2009.05.012. Epub 2009 May 30.


Proteomic profiling of acrolein adducts in human lung epithelial cells.

Spiess PC, Deng B, Hondal RJ, Matthews DE, van der Vliet A.

J Proteomics. 2011 Oct 19;74(11):2380-94. doi: 10.1016/j.jprot.2011.05.039. Epub 2011 Jun 17.


Exposure to acrolein by inhalation causes platelet activation.

Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, Haberzettl P, O'Toole TE, Bhatnagar A, D'Souza SE.

Toxicol Appl Pharmacol. 2010 Oct 15;248(2):100-10. doi: 10.1016/j.taap.2010.07.013. Epub 2010 Aug 3.


Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in mice.

Prows DR, Gibbons WJ Jr, Burzynski BB.

PLoS One. 2012;7(5):e38177. doi: 10.1371/journal.pone.0038177. Epub 2012 May 29.


Monocyte inflammation augments acrolein-induced Muc5ac expression in mouse lung.

Borchers MT, Wesselkamper S, Wert SE, Shapiro SD, Leikauf GD.

Am J Physiol. 1999 Sep;277(3 Pt 1):L489-97.


Acrolein induced both pulmonary inflammation and the death of lung epithelial cells.

Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Isobe K.

Toxicol Lett. 2014 Sep 2;229(2):384-92. doi: 10.1016/j.toxlet.2014.06.021. Epub 2014 Jul 5.


Respiratory Effects and Systemic Stress Response Following Acute Acrolein Inhalation in Rats.

Snow SJ, McGee MA, Henriquez A, Richards JE, Schladweiler MC, Ledbetter AD, Kodavanti UP.

Toxicol Sci. 2017 Aug 1;158(2):454-464. doi: 10.1093/toxsci/kfx108.


Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.

Arai T, Koyama R, Yuasa M, Kitamura D, Mizuta R.

Biomed Res. 2014;35(6):389-95. doi: 10.2220/biomedres.35.389.

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