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Items: 1 to 20 of 108

1.

MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL.

J Immunol. 2011 Sep 1;187(5):2595-601. doi: 10.4049/jimmunol.1100088. Epub 2011 Aug 3.

2.

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.

Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.

3.

MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.

Blaauboer SM, Gabrielle VD, Jin L.

J Immunol. 2014 Jan 1;192(1):492-502. doi: 10.4049/jimmunol.1301812. Epub 2013 Dec 4.

4.

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G.

Nat Immunol. 2012 Dec;13(12):1155-61. doi: 10.1038/ni.2460. Epub 2012 Nov 11.

5.

STING is a direct innate immune sensor of cyclic di-GMP.

Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE.

Nature. 2011 Sep 25;478(7370):515-8. doi: 10.1038/nature10429.

6.

cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.

Storek KM, Gertsvolf NA, Ohlson MB, Monack DM.

J Immunol. 2015 Apr 1;194(7):3236-45. doi: 10.4049/jimmunol.1402764. Epub 2015 Feb 20.

7.

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

Yi G, Brendel VP, Shu C, Li P, Palanathan S, Cheng Kao C.

PLoS One. 2013 Oct 21;8(10):e77846. doi: 10.1371/journal.pone.0077846. eCollection 2013.

9.

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.

Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C.

EMBO Rep. 2013 Oct;14(10):900-6. doi: 10.1038/embor.2013.132. Epub 2013 Sep 6.

10.

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.

McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE.

J Exp Med. 2009 Aug 31;206(9):1899-911. doi: 10.1084/jem.20082874. Epub 2009 Aug 3.

11.

Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING.

Chin KH, Tu ZL, Su YC, Yu YJ, Chen HC, Lo YC, Chen CP, Barber GN, Chuah ML, Liang ZX, Chou SH.

Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):352-66. doi: 10.1107/S0907444912047269. Epub 2013 Feb 16. Erratum in: Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1191.

PMID:
23519410
12.

Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT.

Schwartz KT, Carleton JD, Quillin SJ, Rollins SD, Portnoy DA, Leber JH.

Infect Immun. 2012 Apr;80(4):1537-45. doi: 10.1128/IAI.06286-11. Epub 2012 Jan 30.

13.

STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.

Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC.

J Immunol. 2013 Mar 15;190(6):2835-43. doi: 10.4049/jimmunol.1201788. Epub 2013 Feb 1.

14.

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

Barker JR, Koestler BJ, Carpenter VK, Burdette DL, Waters CM, Vance RE, Valdivia RH.

MBio. 2013 Apr 30;4(3):e00018-13. doi: 10.1128/mBio.00018-13.

15.

Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.

Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K.

Cell Rep. 2015 Apr 7;11(1):71-84. doi: 10.1016/j.celrep.2015.02.066. Epub 2015 Apr 2.

16.

Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG.

Yildiz S, Alpdundar E, Gungor B, Kahraman T, Bayyurt B, Gursel I, Gursel M.

Eur J Immunol. 2015 Apr;45(4):1170-9. doi: 10.1002/eji.201445133. Epub 2015 Feb 4.

17.

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.

Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR.

Nat Med. 2015 Apr;21(4):401-6. doi: 10.1038/nm.3813. Epub 2015 Mar 2.

18.

Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages.

Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X.

J Immunol. 2010 Jun 1;184(11):6447-56. doi: 10.4049/jimmunol.0901750. Epub 2010 Apr 30.

19.

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.

Ma F, Li B, Liu SY, Iyer SS, Yu Y, Wu A, Cheng G.

J Immunol. 2015 Feb 15;194(4):1545-54. doi: 10.4049/jimmunol.1402066. Epub 2015 Jan 21.

20.

Crystallization studies of the murine c-di-GMP sensor protein STING.

Su YC, Tu ZL, Yang CY, Chin KH, Chuah ML, Liang ZX, Chou SH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):906-10. doi: 10.1107/S1744309112024372. Epub 2012 Jul 31.

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