Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 101


CCN1/CYR61: the very model of a modern matricellular protein.

Lau LF.

Cell Mol Life Sci. 2011 Oct;68(19):3149-63. doi: 10.1007/s00018-011-0778-3. Epub 2011 Jul 31. Review.


The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

Borkham-Kamphorst E, Schaffrath C, Van de Leur E, Haas U, Tihaa L, Meurer SK, Nevzorova YA, Liedtke C, Weiskirchen R.

Biochim Biophys Acta. 2014 May;1843(5):902-14. doi: 10.1016/j.bbamcr.2014.01.023. Epub 2014 Jan 31.


Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis.

Franzen CA, Chen CC, Todorović V, Juric V, Monzon RI, Lau LF.

Mol Cancer Res. 2009 Jul;7(7):1045-55. doi: 10.1158/1541-7786.MCR-09-0017. Epub 2009 Jul 7.


Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

Kim KH, Chen CC, Monzon RI, Lau LF.

Mol Cell Biol. 2013 May;33(10):2078-90. doi: 10.1128/MCB.00049-13. Epub 2013 Mar 18.


The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.

Jun JI, Lau LF.

Nat Cell Biol. 2010 Jul;12(7):676-85. doi: 10.1038/ncb2070. Epub 2010 Jun 6. Erratum in: Nat Cell Biol. 2010 Dec;12(12):1249.


Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking.

Emre Y, Imhof BA.

Semin Immunopathol. 2014 Mar;36(2):253-9. doi: 10.1007/s00281-014-0420-1. Epub 2014 Mar 18. Review.


Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.

Juric V, Chen CC, Lau LF.

Mol Cell Biol. 2009 Jun;29(12):3266-79. doi: 10.1128/MCB.00064-09. Epub 2009 Apr 13.


Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages.

Bai T, Chen CC, Lau LF.

J Immunol. 2010 Mar 15;184(6):3223-32. doi: 10.4049/jimmunol.0902792. Epub 2010 Feb 17.


TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release.

Juric V, Chen CC, Lau LF.

PLoS One. 2012;7(2):e31303. doi: 10.1371/journal.pone.0031303. Epub 2012 Feb 17.


The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis.

Haque I, De A, Majumder M, Mehta S, McGregor D, Banerjee SK, Van Veldhuizen P, Banerjee S.

J Biol Chem. 2012 Nov 9;287(46):38569-79. doi: 10.1074/jbc.M112.389064. Epub 2012 Oct 1.


Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions.

Leu SJ, Chen N, Chen CC, Todorovic V, Bai T, Juric V, Liu Y, Yan G, Lam SC, Lau LF.

J Biol Chem. 2004 Oct 15;279(42):44177-87. Epub 2004 Aug 17.


Cellular senescence controls fibrosis in wound healing.

Jun JI, Lau LF.

Aging (Albany NY). 2010 Sep;2(9):627-31.


The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy.

Hasan A, Pokeza N, Shaw L, Lee HS, Lazzaro D, Chintala H, Rosenbaum D, Grant MB, Chaqour B.

J Biol Chem. 2011 Mar 18;286(11):9542-54. doi: 10.1074/jbc.M110.198689. Epub 2011 Jan 6.


Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).

Leu SJ, Liu Y, Chen N, Chen CC, Lam SC, Lau LF.

J Biol Chem. 2003 Sep 5;278(36):33801-8. Epub 2003 Jun 24.


The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.

Chen CC, Mo FE, Lau LF.

J Biol Chem. 2001 Dec 14;276(50):47329-37. Epub 2001 Oct 2.

Supplemental Content

Support Center