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AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J.

J Immunol. 2011 Sep 1;187(5):2464-75. doi: 10.4049/jimmunol.1101406. Epub 2011 Jul 29. Erratum in: J Immunol. 2014 May 15;192(10):4934.


Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.

Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J.

PLoS One. 2015 Aug 12;10(8):e0134397. doi: 10.1371/journal.pone.0134397. eCollection 2015.


AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.

Gu X, Booth CJ, Liu Z, Strout MP.

Blood. 2016 Jan 7;127(1):102-12. doi: 10.1182/blood-2015-02-628164. Epub 2015 Sep 18.


Single-strand DNA breaks in Ig class switch recombination that depend on UNG but not AID.

Arudchandran A, Bernstein RM, Max EE.

Int Immunol. 2008 Nov;20(11):1381-93. doi: 10.1093/intimm/dxn097. Epub 2008 Sep 15.


Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.

Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1016-24. doi: 10.1073/pnas.1402391111. Epub 2014 Mar 3.


C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.

Sabouri S, Kobayashi M, Begum NA, Xu J, Hirota K, Honjo T.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2253-8. doi: 10.1073/pnas.1324057111. Epub 2014 Jan 27.


Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.

Zan H, White CA, Thomas LM, Mai T, Li G, Xu Z, Zhang J, Casali P.

Cell Rep. 2012 Nov 29;2(5):1220-32. doi: 10.1016/j.celrep.2012.09.029. Epub 2012 Nov 8.


Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.

Ucher AJ, Ranjit S, Kadungure T, Linehan EK, Khair L, Xie E, Limauro J, Rauch KS, Schrader CE, Stavnezer J.

J Immunol. 2014 Aug 1;193(3):1440-50. doi: 10.4049/jimmunol.1400365. Epub 2014 Jun 27.


Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.

Shen HM, Tanaka A, Bozek G, Nicolae D, Storb U.

J Immunol. 2006 Oct 15;177(8):5386-92.


Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.

Zan H, Zhang J, Al-Qahtani A, Pone EJ, White CA, Lee D, Yel L, Mai T, Casali P.

Mol Immunol. 2011 Jan;48(4):610-22. doi: 10.1016/j.molimm.2010.10.023. Epub 2010 Nov 26.


Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination.

Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E988-97. doi: 10.1073/pnas.1320486111. Epub 2014 Mar 3.


Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J.

J Immunol. 2007 Nov 1;179(9):6064-71. Erratum in: J Immunol. 2008 Jan 1;180(1):664.


Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.

Yousif AS, Stanlie A, Begum NA, Honjo T.

Int Immunol. 2014 Oct;26(10):575-8. doi: 10.1093/intimm/dxu071. Epub 2014 Jul 3. Review.


Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination.

Cortizas EM, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM, Verdun RE.

J Immunol. 2013 Dec 1;191(11):5751-63. doi: 10.4049/jimmunol.1301300. Epub 2013 Oct 21.


DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J.

DNA Repair (Amst). 2013 Dec;12(12):1087-93. doi: 10.1016/j.dnarep.2013.09.002. Epub 2013 Sep 29.


Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.

Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. doi: 10.1073/pnas.0915072107. Epub 2010 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5731.

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