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Items: 1 to 20 of 111

1.

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.

Maxwell MM, Tomkinson EM, Nobles J, Wizeman JW, Amore AM, Quinti L, Chopra V, Hersch SM, Kazantsev AG.

Hum Mol Genet. 2011 Oct 15;20(20):3986-96. doi: 10.1093/hmg/ddr326. Epub 2011 Jul 26.

3.

Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase.

Nagai T, Ikeda M, Chiba S, Kanno S, Mizuno K.

J Cell Sci. 2013 Oct 1;126(Pt 19):4369-80. doi: 10.1242/jcs.127209. Epub 2013 Jul 25.

4.

Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease.

Patel VP, Chu CT.

Exp Neurol. 2014 Jul;257:170-81. doi: 10.1016/j.expneurol.2014.04.024. Epub 2014 May 2.

5.

SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy.

Yuan Q, Zhan L, Zhou QY, Zhang LL, Chen XM, Hu XM, Yuan XC.

Eur J Pharmacol. 2015 Oct 5;764:554-61. doi: 10.1016/j.ejphar.2015.07.045. Epub 2015 Jul 21.

PMID:
26209361
6.

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

North BJ, Marshall BL, Borra MT, Denu JM, Verdin E.

Mol Cell. 2003 Feb;11(2):437-44.

7.

MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors.

Gold WA, Lacina TA, Cantrill LC, Christodoulou J.

J Mol Med (Berl). 2015 Jan;93(1):63-72. doi: 10.1007/s00109-014-1202-x. Epub 2014 Sep 12.

PMID:
25209898
8.

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.

Wang F, Nguyen M, Qin FX, Tong Q.

Aging Cell. 2007 Aug;6(4):505-14. Epub 2007 May 23.

9.

Angiotensin II induces microtubule reorganization mediated by a deacetylase SIRT2 in endothelial cells.

Hashimoto-Komatsu A, Hirase T, Asaka M, Node K.

Hypertens Res. 2011 Aug;34(8):949-56. doi: 10.1038/hr.2011.64. Epub 2011 Jun 16.

PMID:
21677656
10.

Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.

Nahhas F, Dryden SC, Abrams J, Tainsky MA.

Mol Cell Biochem. 2007 Sep;303(1-2):221-30. Epub 2007 May 22.

PMID:
17516032
11.

The tubulin deacetylase sirtuin-2 regulates neuronal differentiation through the ERK/CREB signaling pathway.

Jeong SG, Cho GW.

Biochem Biophys Res Commun. 2017 Jan 1;482(1):182-187. doi: 10.1016/j.bbrc.2016.11.031. Epub 2016 Nov 9.

PMID:
27838300
12.

The QKI-PLP pathway controls SIRT2 abundance in CNS myelin.

Zhu H, Zhao L, Wang E, Dimova N, Liu G, Feng Y, Cambi F.

Glia. 2012 Jan;60(1):69-82. doi: 10.1002/glia.21248. Epub 2011 Sep 21.

13.

Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin.

Yang W, Guo X, Thein S, Xu F, Sugii S, Baas PW, Radda GK, Han W.

Biochem J. 2013 Feb 1;449(3):605-12. doi: 10.1042/BJ20121121.

PMID:
23126280
15.

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.

Taes I, Timmers M, Hersmus N, Bento-Abreu A, Van Den Bosch L, Van Damme P, Auwerx J, Robberecht W.

Hum Mol Genet. 2013 May 1;22(9):1783-90. doi: 10.1093/hmg/ddt028. Epub 2013 Jan 30.

PMID:
23364049
16.

SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.

Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G.

PLoS One. 2012;7(4):e34805. doi: 10.1371/journal.pone.0034805. Epub 2012 Apr 12.

17.
18.

Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus.

Yoo DY, Kim DW, Kim MJ, Choi JH, Jung HY, Nam SM, Kim JW, Yoon YS, Choi SY, Hwang IK.

Neurol Res. 2015 Jan;37(1):69-76. doi: 10.1179/1743132814Y.0000000416. Epub 2014 Jun 25.

PMID:
24963697
19.

FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).

Voelter-Mahlknecht S, Ho AD, Mahlknecht U.

Int J Oncol. 2005 Nov;27(5):1187-96.

PMID:
16211212
20.

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation.

Yuan F, Xu ZM, Lu LY, Nie H, Ding J, Ying WH, Tian HL.

J Neurochem. 2016 Feb;136(3):581-93. doi: 10.1111/jnc.13423. Epub 2015 Dec 7.

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