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Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone.

Talbot PS, Slifstein M, Hwang DR, Huang Y, Scher E, Abi-Dargham A, Laruelle M.

Neuroimage. 2012 Jan 2;59(1):271-85. doi: 10.1016/j.neuroimage.2011.07.001. Epub 2011 Jul 18.


Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907.

Hinz R, Bhagwagar Z, Cowen PJ, Cunningham VJ, Grasby PM.

J Cereb Blood Flow Metab. 2007 Jan;27(1):161-72. Epub 2006 May 10.


Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907.

Simpson HB, Slifstein M, Bender J Jr, Xu X, Hackett E, Maher MJ, Abi-Dargham A.

Biol Psychiatry. 2011 Nov 1;70(9):897-904. doi: 10.1016/j.biopsych.2011.06.023.


Serotonin 2A receptor agonist binding in the human brain with [(11)C]Cimbi-36: Test-retest reproducibility and head-to-head comparison with the antagonist [(18)F]altanserin.

Ettrup A, Svarer C, McMahon B, da Cunha-Bang S, Lehel S, Møller K, Dyssegaard A, Ganz M, Beliveau V, Jørgensen LM, Gillings N, Knudsen GM.

Neuroimage. 2016 Apr 15;130:167-74. doi: 10.1016/j.neuroimage.2016.02.001. Epub 2016 Feb 11.


PET imaging of central 5-HT2A receptors with carbon-11-MDL 100,907.

Ito H, Nyberg S, Halldin C, Lundkvist C, Farde L.

J Nucl Med. 1998 Jan;39(1):208-14.


Direct comparison of [(18) F]MH.MZ and [(18) F] altanserin for 5-HT2A receptor imaging with PET.

Hansen HD, Ettrup A, Herth MM, Dyssegaard A, Ratner C, Gillings N, Knudsen GM.

Synapse. 2013 Jun;67(6):328-37. doi: 10.1002/syn.21643. Epub 2013 Mar 7.


Characterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: Part 1--pseudoequilibrium interval and quantification methods.

Catafau AM, Danus M, Bullich S, Llop J, Perich J, Cunningham VJ, Plaza P, Penengo MM, Eersels JL, Squassante L, Ros D, Barbanoj M.

J Nucl Med. 2006 Jun;47(6):919-28.


Characterization of [(11)C]Cimbi-36 as an agonist PET radioligand for the 5-HT(2A) and 5-HT(2C) receptors in the nonhuman primate brain.

Finnema SJ, Stepanov V, Ettrup A, Nakao R, Amini N, Svedberg M, Lehmann C, Hansen M, Knudsen GM, Halldin C.

Neuroimage. 2014 Jan 1;84:342-53. doi: 10.1016/j.neuroimage.2013.08.035. Epub 2013 Aug 28.


Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907.

Urban NB, Girgis RR, Talbot PS, Kegeles LS, Xu X, Frankle WG, Hart CL, Slifstein M, Abi-Dargham A, Laruelle M.

Neuropsychopharmacology. 2012 May;37(6):1465-73. doi: 10.1038/npp.2011.332. Epub 2012 Feb 22.


Test-retest reproducibility of binding parameters in humans with 11C-LY2795050, an antagonist PET radiotracer for the κ opioid receptor.

Naganawa M, Zheng MQ, Henry S, Nabulsi N, Lin SF, Ropchan J, Labaree D, Najafzadeh S, Kapinos M, Tauscher J, Neumeister A, Carson RE, Huang Y.

J Nucl Med. 2015 Feb;56(2):243-8. doi: 10.2967/jnumed.114.147975. Epub 2015 Jan 15.


Positron emission tomographic analysis of dose-dependent MDL 100,907 binding to 5-hydroxytryptamine-2A receptors in the human brain.

Andrée B, Nyberg S, Ito H, Ginovart N, Brunner F, Jaquet F, Halldin C, Farde L.

J Clin Psychopharmacol. 1998 Aug;18(4):317-23.


[11C]MDL 100907, a radioligland for selective imaging of 5-HT(2A) receptors with positron emission tomography.

Lundkvist C, Halldin C, Ginovart N, Nyberg S, Swahn CG, Carr AA, Brunner F, Farde L.

Life Sci. 1996;58(10):PL 187-92. Erratum in: Life Sci 1996;58(25):379.


Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses.

Meyer PT, Bhagwagar Z, Cowen PJ, Cunningham VJ, Grasby PM, Hinz R.

Neuroimage. 2010 Apr 15;50(3):984-93. doi: 10.1016/j.neuroimage.2010.01.037. Epub 2010 Jan 18.


Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo.

Marner L, Gillings N, Comley RA, Baaré WF, Rabiner EA, Wilson AA, Houle S, Hasselbalch SG, Svarer C, Gunn RN, Laruelle M, Knudsen GM.

J Nucl Med. 2009 Jun;50(6):900-8. doi: 10.2967/jnumed.108.058552.


Analysis of 5-HT(2A) receptor binding with [(11)C]MDL 100907 in rats: optimization of kinetic modeling.

Visser AK, De Vries EF, Ramakrishnan NK, Willemsen AT, Bosker FJ, den Boer JA, Dierckx RA, van Waarde A.

Mol Imaging Biol. 2013 Dec;15(6):730-8. doi: 10.1007/s11307-013-0633-z.


Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907.

Kristiansen H, Elfving B, Plenge P, Pinborg LH, Gillings N, Knudsen GM.

Synapse. 2005 Dec 15;58(4):249-57.


Characterization of the SPECT 5-HT2A receptor ligand 123I-R91150 in healthy volunteers: part 2--ketanserin displacement.

Catafau AM, Danus M, Bullich S, Nucci G, Llop J, Abanades S, Cunningham VJ, Eersels JL, Pavia J, Farre M.

J Nucl Med. 2006 Jun;47(6):929-37.


Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943.

Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z.

Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):468-77. doi: 10.1007/s00259-014-2958-5. Epub 2014 Nov 27.


Pre- and postsynaptic serotonergic differences in males with extreme levels of impulsive aggression without callous unemotional traits: a positron emission tomography study using (11)C-DASB and (11)C-MDL100907.

Rylands AJ, Hinz R, Jones M, Holmes SE, Feldmann M, Brown G, McMahon AW, Talbot PS.

Biol Psychiatry. 2012 Dec 15;72(12):1004-11. doi: 10.1016/j.biopsych.2012.06.024. Epub 2012 Jul 25.


In vivo quantification of human serotonin 1A receptor using 11C-CUMI-101, an agonist PET radiotracer.

Milak MS, DeLorenzo C, Zanderigo F, Prabhakaran J, Kumar JS, Majo VJ, Mann JJ, Parsey RV.

J Nucl Med. 2010 Dec;51(12):1892-900. doi: 10.2967/jnumed.110.076257.

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