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Items: 1 to 20 of 131

1.

Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.

Meleady P, Doolan P, Henry M, Barron N, Keenan J, O'Sullivan F, Clarke C, Gammell P, Melville MW, Leonard M, Clynes M.

BMC Biotechnol. 2011 Jul 24;11:78. doi: 10.1186/1472-6750-11-78.

2.

2D-DIGE screening of high-productive CHO cells under glucose limitation--basic changes in the proteome equipment and hints for epigenetic effects.

Wingens M, Gätgens J, Schmidt A, Albaum SP, Büntemeyer H, Noll T, Hoffrogge R.

J Biotechnol. 2015 May 10;201:86-97. doi: 10.1016/j.jbiotec.2015.01.005. Epub 2015 Jan 19.

PMID:
25612871
3.

Cell line profiling to improve monoclonal antibody production.

Kang S, Ren D, Xiao G, Daris K, Buck L, Enyenihi AA, Zubarev R, Bondarenko PV, Deshpande R.

Biotechnol Bioeng. 2014 Apr;111(4):748-60. doi: 10.1002/bit.25141. Epub 2013 Nov 19.

PMID:
24249214
4.

More similar than different: Host cell protein production using three null CHO cell lines.

Yuk IH, Nishihara J, Walker D Jr, Huang E, Gunawan F, Subramanian J, Pynn AF, Yu XC, Zhu-Shimoni J, Vanderlaan M, Krawitz DC.

Biotechnol Bioeng. 2015 Oct;112(10):2068-83. doi: 10.1002/bit.25615. Epub 2015 May 12.

PMID:
25894672
5.

Analysis of dynamic changes in the proteome of a Bcl-XL overexpressing Chinese hamster ovary cell culture during exponential and stationary phases.

Carlage T, Kshirsagar R, Zang L, Janakiraman V, Hincapie M, Lyubarskaya Y, Weiskopf A, Hancock WS.

Biotechnol Prog. 2012 May-Jun;28(3):814-23. doi: 10.1002/btpr.1534. Epub 2012 May 2.

PMID:
22556165
6.

Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates.

Kim JY, Kim YG, Han YK, Choi HS, Kim YH, Lee GM.

Appl Microbiol Biotechnol. 2011 Mar;89(6):1917-28. doi: 10.1007/s00253-011-3106-9. Epub 2011 Feb 1.

PMID:
21286710
7.

Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol.

Meleady P, Henry M, Gammell P, Doolan P, Sinacore M, Melville M, Francullo L, Leonard M, Charlebois T, Clynes M.

Proteomics. 2008 Jul;8(13):2611-24. doi: 10.1002/pmic.200700854.

PMID:
18546152
8.

A quantitative proteomic analysis of cellular responses to high glucose media in Chinese hamster ovary cells.

Liu Z, Dai S, Bones J, Ray S, Cha S, Karger BL, Li JJ, Wilson L, Hinckle G, Rossomando A.

Biotechnol Prog. 2015 Jul-Aug;31(4):1026-38. doi: 10.1002/btpr.2090. Epub 2015 Apr 29.

PMID:
25857574
9.

Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles.

Pascoe DE, Arnott D, Papoutsakis ET, Miller WM, Andersen DC.

Biotechnol Bioeng. 2007 Oct 1;98(2):391-410.

PMID:
17461427
10.

A proteomic study of cMyc improvement of CHO culture.

Kuystermans D, Dunn MJ, Al-Rubeai M.

BMC Biotechnol. 2010 Mar 22;10:25. doi: 10.1186/1472-6750-10-25.

11.

Differential protein expression following low temperature culture of suspension CHO-K1 cells.

Kumar N, Gammell P, Meleady P, Henry M, Clynes M.

BMC Biotechnol. 2008 Apr 22;8:42. doi: 10.1186/1472-6750-8-42.

12.

Proteomic analysis of Chinese hamster ovary cells.

Baycin-Hizal D, Tabb DL, Chaerkady R, Chen L, Lewis NE, Nagarajan H, Sarkaria V, Kumar A, Wolozny D, Colao J, Jacobson E, Tian Y, O'Meally RN, Krag SS, Cole RN, Palsson BO, Zhang H, Betenbaugh M.

J Proteome Res. 2012 Nov 2;11(11):5265-76. doi: 10.1021/pr300476w. Epub 2012 Oct 5.

13.

Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins.

Maccani A, Landes N, Stadlmayr G, Maresch D, Leitner C, Maurer M, Gasser B, Ernst W, Kunert R, Mattanovich D.

Biotechnol J. 2014 Apr;9(4):526-37. doi: 10.1002/biot.201300305. Epub 2014 Jan 27.

14.

Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain.

Pybus LP, James DC, Dean G, Slidel T, Hardman C, Smith A, Daramola O, Field R.

Biotechnol Prog. 2014 Jan-Feb;30(1):188-97. doi: 10.1002/btpr.1839. Epub 2013 Dec 6.

PMID:
24311306
15.

Using molecular markers to characterize productivity in Chinese hamster ovary cell lines.

Edros RZ, McDonnell S, Al-Rubeai M.

PLoS One. 2013 Oct 17;8(10):e75935. doi: 10.1371/journal.pone.0075935. eCollection 2013.

16.

Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity.

Clarke C, Doolan P, Barron N, Meleady P, O'Sullivan F, Gammell P, Melville M, Leonard M, Clynes M.

J Biotechnol. 2011 Sep 20;155(3):350-9. doi: 10.1016/j.jbiotec.2011.07.011. Epub 2011 Jul 27.

PMID:
21801763
17.

Hyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant protein production of CHO cells.

Pfizenmaier J, Junghans L, Teleki A, Takors R.

Biotechnol J. 2016 Aug;11(8):1037-47. doi: 10.1002/biot.201500606. Epub 2016 Jun 13.

PMID:
27214792
18.

Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture.

Chong WP, Goh LT, Reddy SG, Yusufi FN, Lee DY, Wong NS, Heng CK, Yap MG, Ho YS.

Rapid Commun Mass Spectrom. 2009 Dec;23(23):3763-71. doi: 10.1002/rcm.4328.

PMID:
19902412
19.

Proteomic profiling of a high-producing Chinese hamster ovary cell culture.

Carlage T, Hincapie M, Zang L, Lyubarskaya Y, Madden H, Mhatre R, Hancock WS.

Anal Chem. 2009 Sep 1;81(17):7357-62. doi: 10.1021/ac900792z.

PMID:
19663468
20.

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation.

Könitzer JD, Müller MM, Leparc G, Pauers M, Bechmann J, Schulz P, Schaub J, Enenkel B, Hildebrandt T, Hampel M, Tolstrup AB.

Biotechnol J. 2015 Sep;10(9):1412-23. doi: 10.1002/biot.201400652. Epub 2015 Aug 26.

PMID:
26212696

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