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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y.

Science. 2011 Sep 2;333(6047):1300-3. doi: 10.1126/science.1210597. Epub 2011 Jul 21.


Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL.

Science. 2011 Sep 2;333(6047):1303-7. doi: 10.1126/science.1210944. Epub 2011 Aug 4.


Structural insight into substrate preference for TET-mediated oxidation.

Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y.

Nature. 2015 Nov 5;527(7576):118-22. doi: 10.1038/nature15713. Epub 2015 Oct 28.


Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation.

Wu H, Zhang Y.

Genes Dev. 2011 Dec 1;25(23):2436-52. doi: 10.1101/gad.179184.111. Review.


Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.

Hashimoto H, Pais JE, Zhang X, Saleh L, Fu ZQ, Dai N, CorrĂȘa IR Jr, Zheng Y, Cheng X.

Nature. 2014 Feb 20;506(7488):391-5. doi: 10.1038/nature12905. Epub 2013 Dec 25.


Structure and Function of TET Enzymes.

Yin X, Xu Y.

Adv Exp Med Biol. 2016;945:275-302. Review.


A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine.

Zhang L, Chen W, Iyer LM, Hu J, Wang G, Fu Y, Yu M, Dai Q, Aravind L, He C.

J Am Chem Soc. 2014 Apr 2;136(13):4801-4. doi: 10.1021/ja500979k. Epub 2014 Mar 25.


PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.

Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y.

Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11.


Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

Inoue A, Shen L, Dai Q, He C, Zhang Y.

Cell Res. 2011 Dec;21(12):1670-6. doi: 10.1038/cr.2011.189. Epub 2011 Nov 29.


Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming.

Song CX, Szulwach KE, Dai Q, Fu Y, Mao SQ, Lin L, Street C, Li Y, Poidevin M, Wu H, Gao J, Liu P, Li L, Xu GL, Jin P, He C.

Cell. 2013 Apr 25;153(3):678-91. doi: 10.1016/j.cell.2013.04.001. Epub 2013 Apr 18.


Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.

Shen L, Wu H, Diep D, Yamaguchi S, D'Alessio AC, Fung HL, Zhang K, Zhang Y.

Cell. 2013 Apr 25;153(3):692-706. doi: 10.1016/j.cell.2013.04.002. Epub 2013 Apr 18.


TET proteins and 5-methylcytosine oxidation in hematological cancers.

Ko M, An J, Pastor WA, Koralov SB, Rajewsky K, Rao A.

Immunol Rev. 2015 Jan;263(1):6-21. doi: 10.1111/imr.12239. Review.


Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine.

Xiong J, Zhang Z, Chen J, Huang H, Xu Y, Ding X, Zheng Y, Nishinakamura R, Xu GL, Wang H, Chen S, Gao S, Zhu B.

Mol Cell. 2016 Dec 1;64(5):913-925. doi: 10.1016/j.molcel.2016.10.013. Epub 2016 Nov 10.


Transcriptional activation of transposable elements in mouse zygotes is independent of Tet3-mediated 5-methylcytosine oxidation.

Inoue A, Matoba S, Zhang Y.

Cell Res. 2012 Dec;22(12):1640-9. doi: 10.1038/cr.2012.160. Epub 2012 Nov 27. Erratum in: Cell Res. 2018 Feb;28(2):261.


Connections between TET proteins and aberrant DNA modification in cancer.

Huang Y, Rao A.

Trends Genet. 2014 Oct;30(10):464-74. doi: 10.1016/j.tig.2014.07.005. Epub 2014 Aug 14. Review.


Comparative dynamics of 5-methylcytosine reprogramming and TET family expression during preimplantation mammalian development in mouse and sheep.

Jafarpour F, Hosseini SM, Ostadhosseini S, Abbasi H, Dalman A, Nasr-Esfahani MH.

Theriogenology. 2017 Feb;89:86-96. doi: 10.1016/j.theriogenology.2016.10.010. Epub 2016 Oct 20.


Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword.

Ito S, Kuraoka I.

DNA Repair (Amst). 2015 Aug;32:52-7. doi: 10.1016/j.dnarep.2015.04.013. Epub 2015 May 1. Review.


Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

Nettersheim D, Heukamp LC, Fronhoffs F, Grewe MJ, Haas N, Waha A, Honecker F, Waha A, Kristiansen G, Schorle H.

PLoS One. 2013 Dec 26;8(12):e82881. doi: 10.1371/journal.pone.0082881. eCollection 2013.


Role of Tet proteins in enhancer activity and telomere elongation.

Lu F, Liu Y, Jiang L, Yamaguchi S, Zhang Y.

Genes Dev. 2014 Oct 1;28(19):2103-19. doi: 10.1101/gad.248005.114. Epub 2014 Sep 15.


Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.

Blaschke K, Ebata KT, Karimi MM, Zepeda-MartĂ­nez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M.

Nature. 2013 Aug 8;500(7461):222-6. doi: 10.1038/nature12362. Epub 2013 Jun 30.

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