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Items: 1 to 20 of 120

1.

Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.

Naiyanetr P, Butler JD, Meng L, Pfeiff J, Kenny TP, Guggenheim KG, Reiger R, Lam K, Kurth MJ, Ansari AA, Coppel RL, López-Hoyos M, Gershwin ME, Leung PS.

J Autoimmun. 2011 Nov;37(3):209-16. doi: 10.1016/j.jaut.2011.06.001. Epub 2011 Jul 18.

2.

Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis.

Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, Guggenheim KC, Butler JD, Bowlus C, Tao MH, Kurth MJ, Ansari AA, Kaplan M, Coppel RL, Lleo A, Gershwin ME, Leung PS.

Hepatology. 2013 Apr;57(4):1498-508. doi: 10.1002/hep.26157. Epub 2013 Jan 29.

3.

Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid.

Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, Suen YF, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Matsuura E, Coppel RL, Gershwin ME.

J Immunol. 2005 May 1;174(9):5874-83.

4.

Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA.

Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, Gershwin ME.

J Autoimmun. 2013 Mar;41:79-86. doi: 10.1016/j.jaut.2012.12.007. Epub 2013 Jan 24.

5.

The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis.

Ambrosini YM, Yang GX, Zhang W, Tsuda M, Shu S, Tsuneyama K, Leung PS, Ansari AA, Coppel RL, Gershwin ME.

Clin Exp Immunol. 2011 Oct;166(1):110-20. doi: 10.1111/j.1365-2249.2011.04453.x.

6.

Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies.

Leung PS, Quan C, Park O, Van de Water J, Kurth MJ, Nantz MH, Ansari AA, Coppel RL, Lam KS, Gershwin ME.

J Immunol. 2003 May 15;170(10):5326-32.

7.

Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.

Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, Bach JF, Gershwin ME.

J Autoimmun. 2000 Aug;15(1):51-60.

PMID:
10936028
8.

Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies.

Moteki S, Leung PS, Coppel RL, Dickson ER, Kaplan MM, Munoz S, Gershwin ME.

Hepatology. 1996 Jul;24(1):97-103.

PMID:
8707289
9.

Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.

Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME.

Hepatology. 2008 Aug;48(2):531-40. doi: 10.1002/hep.22390.

10.

Xenobiotics and loss of tolerance in primary biliary cholangitis.

Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS.

World J Gastroenterol. 2016 Jan 7;22(1):338-48. doi: 10.3748/wjg.v22.i1.338. Review.

11.

The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.

Shimoda S, Tsuneyama K, Kikuchi K, Harada K, Nakanuma Y, Nakamura M, Ishibashi H, Hisamoto S, Niiro H, Leung PS, Ansari AA, Gershwin ME, Akashi K.

Clin Exp Immunol. 2012 Jun;168(3):279-84. doi: 10.1111/j.1365-2249.2012.04581.x.

12.

Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?

Leung PS, Lam K, Kurth MJ, Coppel RL, Gershwin ME.

Trends Mol Med. 2012 Oct;18(10):577-82. doi: 10.1016/j.molmed.2012.07.005. Epub 2012 Aug 21.

13.

The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis.

Shuai Z, Wang J, Badamagunta M, Choi J, Yang G, Zhang W, Kenny TP, Guggenheim K, Kurth MJ, Ansari AA, Voss J, Coppel RL, Invernizzi P, Leung PSC, Gershwin ME.

Hepatology. 2017 May;65(5):1670-1682. doi: 10.1002/hep.29059. Epub 2017 Mar 31.

PMID:
28100006
14.

Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice.

Wang JJ, Yang GX, Zhang WC, Lu L, Tsuneyama K, Kronenberg M, Véla JL, Lopez-Hoyos M, He XS, Ridgway WM, Leung PS, Gershwin ME.

Clin Exp Immunol. 2014 Feb;175(2):192-201. doi: 10.1111/cei.12224.

15.

Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis.

Nishio A, Van de Water J, Leung PS, Joplin R, Neuberger JM, Lake J, Björkland A, Tötterman TH, Peters M, Worman HJ, Ansari AA, Coppel RL, Gershwin ME.

Hepatology. 1997 May;25(5):1085-9.

PMID:
9141421
16.

Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization.

Leung PS, Park O, Tsuneyama K, Kurth MJ, Lam KS, Ansari AA, Coppel RL, Gershwin ME.

J Immunol. 2007 Aug 15;179(4):2651-7.

17.

Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis.

Bruggraber SF, Leung PS, Amano K, Quan C, Kurth MJ, Nantz MH, Benson GD, Van de Water J, Luketic V, Roche TE, Ansari AA, Coppel RL, Gershwin ME.

Gastroenterology. 2003 Dec;125(6):1705-13.

PMID:
14724823
18.

Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex.

Wang J, Budamagunta MS, Voss JC, Kurth MJ, Lam KS, Lu L, Kenny TP, Bowlus C, Kikuchi K, Coppel RL, Ansari AA, Gershwin ME, Leung PS.

J Immunol. 2013 Sep 1;191(5):2126-33. doi: 10.4049/jimmunol.1301092. Epub 2013 Jul 26.

19.

Serum reactivity against bacterial pyruvate dehydrogenase: increasing the specificity of anti-mitochondrial antibodies for the diagnosis of primary biliary cirrhosis.

Miyakawa H, Tanaka A, Selmi C, Hosoya N, Mataki N, Kikuchi K, Kato T, Arai J, Goto T, Gershwin ME.

Clin Dev Immunol. 2006 Jun-Dec;13(2-4):289-94.

20.

Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.

Amano K, Leung PS, Xu Q, Marik J, Quan C, Kurth MJ, Nantz MH, Ansari AA, Lam KS, Zeniya M, Coppel RL, Gershwin ME.

J Immunol. 2004 May 15;172(10):6444-52.

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