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Items: 1 to 20 of 107


The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo.

Iscla I, Wray R, Blount P.

Protein Sci. 2011 Sep;20(9):1638-42. doi: 10.1002/pro.686. Epub 2011 Jul 19.


S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins.

Dorwart MR, Wray R, Brautigam CA, Jiang Y, Blount P.

PLoS Biol. 2010 Dec 7;8(12):e1000555. doi: 10.1371/journal.pbio.1000555.


Phosphatidylinositol is crucial for the mechanosensitivity of Mycobacterium tuberculosis MscL.

Zhong D, Blount P.

Biochemistry. 2013 Aug 13;52(32):5415-20. doi: 10.1021/bi400790j. Epub 2013 Aug 1.


Structure of a tetrameric MscL in an expanded intermediate state.

Liu Z, Gandhi CS, Rees DC.

Nature. 2009 Sep 3;461(7260):120-4. doi: 10.1038/nature08277. Epub 2009 Aug 23.


A cytoplasmic helix is required for pentamer formation of the Escherichia coli MscL mechanosensitive channel.

Ando C, Liu N, Yoshimura K.

J Biochem. 2015 Aug;158(2):109-14. doi: 10.1093/jb/mvv019. Epub 2015 Feb 19.


On the structure of the N-terminal domain of the MscL channel: helical bundle or membrane interface.

Iscla I, Wray R, Blount P.

Biophys J. 2008 Sep;95(5):2283-91. doi: 10.1529/biophysj.107.127423. Epub 2008 May 30.


The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry.

Reading E, Walton TA, Liko I, Marty MT, Laganowsky A, Rees DC, Robinson CV.

Chem Biol. 2015 May 21;22(5):593-603. doi: 10.1016/j.chembiol.2015.04.016.


Structure and stability of the C-terminal helical bundle of the E. coli mechanosensitive channel of large conductance.

Walton TA, Rees DC.

Protein Sci. 2013 Nov;22(11):1592-601. doi: 10.1002/pro.2360. Epub 2013 Sep 30.


Stoichiometry of the large conductance bacterial mechanosensitive channel of E. coli. A biochemical study.

Sukharev SI, Schroeder MJ, McCaslin DR.

J Membr Biol. 1999 Oct 1;171(3):183-93.


Gating the bacterial mechanosensitive channel MscL invivo.

Batiza AF, Kuo MM, Yoshimura K, Kung C.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5643-8.


Structure and function of the bacterial mechanosensitive channel of large conductance.

Oakley AJ, Martinac B, Wilce MC.

Protein Sci. 1999 Oct;8(10):1915-21. Review.


Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel.

Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC.

Science. 1998 Dec 18;282(5397):2220-6.


Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity.

Yang LM, Zhong D, Blount P.

Cell Rep. 2013 Feb 21;3(2):520-7. doi: 10.1016/j.celrep.2013.01.018. Epub 2013 Feb 14.


Electrostatics at the membrane define MscL channel mechanosensitivity and kinetics.

Zhong D, Blount P.

FASEB J. 2014 Dec;28(12):5234-41. doi: 10.1096/fj.14-259309. Epub 2014 Sep 15.


Release of thioredoxin via the mechanosensitive channel MscL during osmotic downshock of Escherichia coli cells.

Ajouz B, Berrier C, Garrigues A, Besnard M, Ghazi A.

J Biol Chem. 1998 Oct 9;273(41):26670-4.


Gating of the mechanosensitive channel protein MscL: the interplay of membrane and protein.

Jeon J, Voth GA.

Biophys J. 2008 May 1;94(9):3497-511. doi: 10.1529/biophysj.107.109850. Epub 2008 Jan 22.


Confirming the revised C-terminal domain of the MscL crystal structure.

Maurer JA, Elmore DE, Clayton D, Xiong L, Lester HA, Dougherty DA.

Biophys J. 2008 Jun;94(12):4662-7. doi: 10.1529/biophysj.107.127365. Epub 2008 Mar 7.


Correlating a protein structure with function of a bacterial mechanosensitive channel.

Moe PC, Levin G, Blount P.

J Biol Chem. 2000 Oct 6;275(40):31121-7.


In vitro synthesis and oligomerization of the mechanosensitive channel of large conductance, MscL, into a functional ion channel.

Price CE, Kocer A, Kol S, van der Berg JP, Driessen AJ.

FEBS Lett. 2011 Jan 3;585(1):249-54. doi: 10.1016/j.febslet.2010.11.057. Epub 2010 Dec 8.

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