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Items: 1 to 20 of 109

1.

Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.

Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG.

Cell Metab. 2011 Jul 6;14(1):67-79. doi: 10.1016/j.cmet.2011.04.013.

2.
3.

The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity.

Tsurutani Y, Fujimoto M, Takemoto M, Irisuna H, Koshizaka M, Onishi S, Ishikawa T, Mezawa M, He P, Honjo S, Maezawa Y, Saito Y, Yokote K.

Biochem Biophys Res Commun. 2011 Apr 1;407(1):68-73. doi: 10.1016/j.bbrc.2011.02.106. Epub 2011 Feb 26.

PMID:
21356196
4.

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.

Qian SW, Tang Y, Li X, Liu Y, Zhang YY, Huang HY, Xue RD, Yu HY, Guo L, Gao HD, Liu Y, Sun X, Li YM, Jia WP, Tang QQ.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E798-807. doi: 10.1073/pnas.1215236110. Epub 2013 Feb 6.

5.

Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet.

Tan CK, Leuenberger N, Tan MJ, Yan YW, Chen Y, Kambadur R, Wahli W, Tan NS.

Diabetes. 2011 Feb;60(2):464-76. doi: 10.2337/db10-0801.

6.

Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function.

Lin HM, Lee JH, Yadav H, Kamaraju AK, Liu E, Zhigang D, Vieira A, Kim SJ, Collins H, Matschinsky F, Harlan DM, Roberts AB, Rane SG.

J Biol Chem. 2009 May 1;284(18):12246-57. doi: 10.1074/jbc.M805379200. Epub 2009 Mar 5.

7.

From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity.

Castillo-Quan JI.

Dis Model Mech. 2012 May;5(3):293-5. doi: 10.1242/dmm.009894. No abstract available.

9.

The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice.

Soofi A, Wolf KI, Emont MP, Qi N, Martinez-Santibanez G, Grimley E, Ostwani W, Dressler GR.

J Biol Chem. 2017 Jun 2;292(22):9051-9062. doi: 10.1074/jbc.M116.771428. Epub 2017 Apr 19.

PMID:
28424263
10.
12.

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.

Ma X, Xu L, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E.

Cell Metab. 2015 Oct 6;22(4):695-708. doi: 10.1016/j.cmet.2015.08.005. Epub 2015 Sep 3.

13.

Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts.

Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, Roberts AB.

J Biol Chem. 2001 Jun 8;276(23):19945-53. Epub 2001 Mar 21.

14.

Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-beta/Smad3 signaling.

Zhou S, Lechpammer S, Greenberger JS, Glowacki J.

J Biol Chem. 2005 Jun 17;280(24):22688-96. Epub 2005 Apr 20.

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16.

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.

Pan D, Fujimoto M, Lopes A, Wang YX.

Cell. 2009 Apr 3;137(1):73-86. doi: 10.1016/j.cell.2009.01.051.

17.

Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.

Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P.

J Biol Chem. 2002 Oct 11;277(41):38399-408. Epub 2002 Aug 2.

18.

TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis.

Yadav H, Devalaraja S, Chung ST, Rane SG.

J Biol Chem. 2017 Feb 24;292(8):3420-3432. doi: 10.1074/jbc.M116.764910. Epub 2017 Jan 9.

PMID:
28069811
20.

CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

Xin H, Xu X, Li L, Ning H, Rong Y, Shang Y, Wang Y, Fu XY, Chang Z.

J Biol Chem. 2005 May 27;280(21):20842-50. Epub 2005 Mar 21.

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