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Items: 1 to 20 of 102

1.

Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes.

Li T, Li N, Guo Q, Ji H, Zhao D, Xie S, Li X, Qiu Z, Han D, Chen X, You Q.

Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):249-56. doi: 10.1007/s13318-011-0050-0. Epub 2011 Jun 29.

PMID:
21713461
2.

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

Wen X, Wang JS, Backman JT, Kivistö KT, Neuvonen PJ.

Drug Metab Dispos. 2001 Nov;29(11):1359-61.

3.

Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro.

Chang SY, Chen C, Yang Z, Rodrigues AD.

Drug Metab Dispos. 2009 Aug;37(8):1667-75. doi: 10.1124/dmd.109.026997. Epub 2009 May 19.

4.
6.

The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.

Yao HT, Chang YW, Lan SJ, Chen CT, Hsu JT, Yeh TK.

Life Sci. 2006 Nov 25;79(26):2432-40. Epub 2006 Aug 23.

PMID:
16978661
7.

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.

Ko JW, Desta Z, Soukhova NV, Tracy T, Flockhart DA.

Br J Clin Pharmacol. 2000 Apr;49(4):343-51.

8.

In vitro effects of tacrolimus on human cytochrome P450.

Lecointre K, Furlan V, Taburet AM.

Fundam Clin Pharmacol. 2002 Dec;16(6):455-60.

PMID:
12685503
9.

Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4.

Jin C, He X, Zhang F, He L, Chen J, Wang L, An L, Fan Y.

Xenobiotica. 2015;45(7):571-7. doi: 10.3109/00498254.2014.1003113. Epub 2015 Mar 26.

PMID:
25811791
10.

Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.

Wen X, Wang JS, Neuvonen PJ, Backman JT.

Eur J Clin Pharmacol. 2002 Jan;57(11):799-804.

PMID:
11868802
11.

Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.

Jeurissen SM, Bogaards JJ, Boersma MG, ter Horst JP, Awad HM, Fiamegos YC, van Beek TA, Alink GM, Sudhölter EJ, Cnubben NH, Rietjens IM.

Chem Res Toxicol. 2006 Jan;19(1):111-6.

PMID:
16411663
12.

Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 in vitro using a single point IC(50).

Gao F, Johnson DL, Ekins S, Janiszewski J, Kelly KG, Meyer RD, West M.

J Biomol Screen. 2002 Aug;7(4):373-82.

PMID:
12230892
13.

Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.

Lim HK, Duczak N Jr, Brougham L, Elliot M, Patel K, Chan K.

Drug Metab Dispos. 2005 Aug;33(8):1211-9. Epub 2005 Apr 28.

15.

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.

Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ.

J Pharm Pharmacol. 1998 Mar;50(3):265-74.

PMID:
9600717
16.
17.

Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.

Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A.

Drug Metab Dispos. 2010 Jan;38(1):92-9. doi: 10.1124/dmd.109.029132.

18.

Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro.

He M, Jiang J, Qiu F, Liu S, Peng P, Gao C, Miao P.

Food Chem Toxicol. 2013 Jul;57:262-5. doi: 10.1016/j.fct.2013.03.041. Epub 2013 Apr 9.

PMID:
23583485
19.

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.

von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI.

J Pharm Pharmacol. 1998 Sep;50(9):997-1004.

PMID:
9811160
20.

Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes.

Bae SH, Kwon MJ, Choi EJ, Zheng YF, Yoon KD, Liu KH, Bae SK.

Chem Biol Interact. 2013 Sep 5;205(1):11-9. doi: 10.1016/j.cbi.2013.06.006. Epub 2013 Jun 15.

PMID:
23777987

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