Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 123

1.
3.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

PMID:
23773065
4.

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.

Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW.

Mol Neurodegener. 2012 Jun 18;7:30. doi: 10.1186/1750-1326-7-30.

5.

CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.

Singh AK, Pati U.

Aging Cell. 2015 Aug;14(4):595-604. doi: 10.1111/acel.12335. Epub 2015 Mar 13.

6.

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.

Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W.

FASEB J. 2005 May;19(7):739-49.

PMID:
15857888
7.

Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.

Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, van der Brug M, Liu Y, Ernst JA, Watts RJ, Atwal JK.

J Biol Chem. 2014 Nov 7;289(45):30990-1000. doi: 10.1074/jbc.M114.589069. Epub 2014 Sep 24.

9.

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.

10.

Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.

Marwarha G, Raza S, Prasanthi JR, Ghribi O.

PLoS One. 2013 Aug 9;8(8):e70773. doi: 10.1371/journal.pone.0070773. eCollection 2013 Aug 9.

11.
12.

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.

Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KM, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M.

Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.

PMID:
26563932
13.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.

J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80.

PMID:
15851852
14.

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y, Song W.

Int J Neuropsychopharmacol. 2012 Feb;15(1):77-90. doi: 10.1017/S1461145711000149. Epub 2011 Feb 18.

PMID:
21329555
15.

MicroRNA-384 regulates both amyloid precursor protein and β-secretase expression and is a potential biomarker for Alzheimer's disease.

Liu CG, Wang JL, Li L, Wang PC.

Int J Mol Med. 2014 Jul;34(1):160-6. doi: 10.3892/ijmm.2014.1780. Epub 2014 May 13.

PMID:
24827165
16.

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells.

Chen LM, Lin ZY, Zhu YG, Lin N, Zhang J, Pan XD, Chen XC.

Eur J Pharmacol. 2012 Jan 30;675(1-3):15-21. doi: 10.1016/j.ejphar.2011.11.039. Epub 2011 Dec 7.

PMID:
22166376
17.

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R.

Neuron. 2008 Dec 26;60(6):988-1009. doi: 10.1016/j.neuron.2008.10.047.

18.

A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.

Yang SG, Wang SW, Zhao M, Zhang R, Zhou WW, Li YN, Su YJ, Zhang H, Yu XL, Liu RT.

PLoS One. 2012;7(11):e48540. doi: 10.1371/journal.pone.0048540. Epub 2012 Nov 1.

19.

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.

Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT.

J Biol Chem. 2004 Dec 10;279(50):52535-42. Epub 2004 Sep 27.

20.

BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology.

Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX.

Neurotox Res. 2012 Feb;21(2):160-74. doi: 10.1007/s12640-011-9256-9. Epub 2011 Jul 2.

Supplemental Content

Support Center