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Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.

Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG.

Chem Biol. 2011 Jun 24;18(6):752-65. doi: 10.1016/j.chembiol.2011.03.013.


Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A.

Free Radic Biol Med. 2012 Jan 15;52(2):473-87. doi: 10.1016/j.freeradbiomed.2011.11.003.


Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M.

Arch Biochem Biophys. 2005 Jan 15;433(2):342-50. Review.


Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.

Mol Cell Biol. 2004 Dec;24(24):10941-53.


Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.

Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M.

Mol Cell Biol. 2006 Apr;26(8):2887-900.


Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K, Motohashi H, Yamamoto M.

Genes Cells. 2011 Feb;16(2):123-40. doi: 10.1111/j.1365-2443.2010.01473.x. Review.


Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway.

Wu KC, McDonald PR, Liu JJ, Chaguturu R, Klaassen CD.

PLoS One. 2012;7(10):e44686. doi: 10.1371/journal.pone.0044686.


MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism.

Yang M, Yao Y, Eades G, Zhang Y, Zhou Q.

Breast Cancer Res Treat. 2011 Oct;129(3):983-91. doi: 10.1007/s10549-011-1604-1.


A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.

Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10.


Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes.

Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J.

Environ Health Perspect. 2012 Apr;120(4):583-9. doi: 10.1289/ehp.1104580.


Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Jiang ZY, Lu MC, Xu LL, Yang TT, Xi MY, Xu XL, Guo XK, Zhang XJ, You QD, Sun HP.

J Med Chem. 2014 Mar 27;57(6):2736-45. doi: 10.1021/jm5000529. Erratum in: J Med Chem. 2014 May 22;57(10):4406. Dosage error in article text.


Discovery of the negative regulator of Nrf2, Keap1: a historical overview.

Itoh K, Mimura J, Yamamoto M.

Antioxid Redox Signal. 2010 Dec 1;13(11):1665-78. doi: 10.1089/ars.2010.3222. Review.


Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals.

Ramkumar KM, Sekar TV, Foygel K, Elango B, Paulmurugan R.

Anal Chem. 2013 Aug 6;85(15):7542-9. doi: 10.1021/ac401569j.


Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction.

Hancock R, Bertrand HC, Tsujita T, Naz S, El-Bakry A, Laoruchupong J, Hayes JD, Wells G.

Free Radic Biol Med. 2012 Jan 15;52(2):444-51. doi: 10.1016/j.freeradbiomed.2011.10.486.


Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.

Sun Z, Chin YE, Zhang DD.

Mol Cell Biol. 2009 May;29(10):2658-72. doi: 10.1128/MCB.01639-08.


Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.

Marcotte D, Zeng W, Hus JC, McKenzie A, Hession C, Jin P, Bergeron C, Lugovskoy A, Enyedy I, Cuervo H, Wang D, Atmanene C, Roecklin D, Vecchi M, Vivat V, Kraemer J, Winkler D, Hong V, Chao J, Lukashev M, Silvian L.

Bioorg Med Chem. 2013 Jul 15;21(14):4011-9. doi: 10.1016/j.bmc.2013.04.019.


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