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Items: 1 to 20 of 99

1.

Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.

Benned-Jensen T, Smethurst C, Holst PJ, Page KR, Sauls H, Sivertsen B, Schwartz TW, Blanchard A, Jepras R, Rosenkilde MM.

J Biol Chem. 2011 Aug 19;286(33):29292-302. doi: 10.1074/jbc.M110.196345. Epub 2011 Jun 14.

2.

Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.

Benned-Jensen T, Rosenkilde MM.

Mol Pharmacol. 2008 Oct;74(4):1008-21. doi: 10.1124/mol.108.049676. Epub 2008 Jul 15.

3.

Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation.

Benned-Jensen T, Madsen CM, Arfelt KN, Smethurts C, Blanchard A, Jepras R, Rosenkilde MM.

FEBS Open Bio. 2013 Feb 19;3:156-60. doi: 10.1016/j.fob.2013.02.003. Print 2013.

4.

Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.

Daugvilaite V, Madsen CM, Lückmann M, Echeverria CC, Sailer AW, Frimurer TM, Rosenkilde MM, Benned-Jensen T.

Br J Pharmacol. 2017 Jul;174(13):2031-2042. doi: 10.1111/bph.13801. Epub 2017 May 4.

PMID:
28369721
5.

Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.

Rosenkilde MM, Benned-Jensen T, Andersen H, Holst PJ, Kledal TN, Lüttichau HR, Larsen JK, Christensen JP, Schwartz TW.

J Biol Chem. 2006 May 12;281(19):13199-208. Epub 2006 Mar 15.

6.

EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.

Barroso R, Martínez Muñoz L, Barrondo S, Vega B, Holgado BL, Lucas P, Baíllo A, Sallés J, Rodríguez-Frade JM, Mellado M.

FASEB J. 2012 Dec;26(12):4841-54. doi: 10.1096/fj.12-208876. Epub 2012 Aug 22.

PMID:
22913878
7.

EBI2 mediates B cell segregation between the outer and centre follicle.

Pereira JP, Kelly LM, Xu Y, Cyster JG.

Nature. 2009 Aug 27;460(7259):1122-6. doi: 10.1038/nature08226. Epub 2009 Jul 13.

8.

Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.

Zhang L, Shih AY, Yang XV, Kuei C, Wu J, Deng X, Mani NS, Mirzadegan T, Sun S, Lovenberg TW, Liu C.

Mol Pharmacol. 2012 Dec;82(6):1094-103. doi: 10.1124/mol.112.080275. Epub 2012 Aug 28.

9.

EBI2 regulates intracellular signaling and migration in human astrocyte.

Rutkowska A, Preuss I, Gessier F, Sailer AW, Dev KK.

Glia. 2015 Feb;63(2):341-51. doi: 10.1002/glia.22757. Epub 2014 Oct 9.

PMID:
25297897
10.

Oxysterol-EBI2 signaling in immune regulation and viral infection.

Daugvilaite V, Arfelt KN, Benned-Jensen T, Sailer AW, Rosenkilde MM.

Eur J Immunol. 2014 Jul;44(7):1904-12. doi: 10.1002/eji.201444493. Epub 2014 Jun 20. Review.

11.

Oxysterols direct B-cell migration through EBI2.

Liu C, Yang XV, Wu J, Kuei C, Mani NS, Zhang L, Yu J, Sutton SW, Qin N, Banie H, Karlsson L, Sun S, Lovenberg TW.

Nature. 2011 Jul 27;475(7357):519-23. doi: 10.1038/nature10226.

PMID:
21796211
12.

Oxysterols direct immune cell migration via EBI2.

Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW.

Nature. 2011 Jul 27;475(7357):524-7. doi: 10.1038/nature10280.

13.

Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways.

Shen ZJ, Hu J, Kashi VP, Kelly EA, Denlinger LC, Lutchman K, McDonald JG, Jarjour NN, Malter JS.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1576-1585. doi: 10.1164/rccm.201608-1580OC.

PMID:
28125291
14.

B cell localization: regulation by EBI2 and its oxysterol ligand.

Gatto D, Brink R.

Trends Immunol. 2013 Jul;34(7):336-41. doi: 10.1016/j.it.2013.01.007. Epub 2013 Mar 5. Review.

PMID:
23481574
15.

Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.

Gessier F, Preuss I, Yin H, Rosenkilde MM, Laurent S, Endres R, Chen YA, Marsilje TH, Seuwen K, Nguyen DG, Sailer AW.

J Med Chem. 2014 Apr 24;57(8):3358-68. doi: 10.1021/jm4019355. Epub 2014 Apr 15.

PMID:
24678947
17.

Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).

Benned-Jensen T, Norn C, Laurent S, Madsen CM, Larsen HM, Arfelt KN, Wolf RM, Frimurer T, Sailer AW, Rosenkilde MM.

J Biol Chem. 2012 Oct 12;287(42):35470-83. doi: 10.1074/jbc.M112.387894. Epub 2012 Aug 8.

18.

EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues.

Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG.

J Immunol. 2011 Sep 15;187(6):3026-32. doi: 10.4049/jimmunol.1101262. Epub 2011 Aug 15.

19.

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW.

J Biol Chem. 2007 May 25;282(21):15799-811. Epub 2007 Mar 19.

20.

Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.

Gatto D, Paus D, Basten A, Mackay CR, Brink R.

Immunity. 2009 Aug 21;31(2):259-69. doi: 10.1016/j.immuni.2009.06.016. Epub 2009 Jul 16.

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