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Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma.

Yan J, Diaz J, Jiao J, Wang R, You J.

J Biol Chem. 2011 Aug 5;286(31):27663-75. doi: 10.1074/jbc.M111.246975. Epub 2011 Jun 7.


Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation.

Wang R, You J.

J Biol Chem. 2015 Jan 30;290(5):2744-58. doi: 10.1074/jbc.M114.600759. Epub 2014 Dec 15.


BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC.

Oncogene. 2008 Apr 3;27(15):2237-42. Epub 2007 Oct 15.


Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma.

Thompson-Wicking K, Francis RW, Stirnweiss A, Ferrari E, Welch MD, Baker E, Murch AR, Gout AM, Carter KW, Charles AK, Phillips MB, Kees UR, Beesley AH.

Oncogene. 2013 Sep 26;32(39):4664-74. doi: 10.1038/onc.2012.487. Epub 2012 Nov 5.


Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.

Wang R, Liu W, Helfer CM, Bradner JE, Hornick JL, Janicki SM, French CA, You J.

Cancer Res. 2014 Jun 15;74(12):3332-43. doi: 10.1158/0008-5472.CAN-13-2658. Epub 2014 Apr 15.


Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.

Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, Khochbin S.

EMBO J. 2010 Sep 1;29(17):2943-52. doi: 10.1038/emboj.2010.176. Epub 2010 Jul 30.


BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.

French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA.

Cancer Res. 2003 Jan 15;63(2):304-7.


NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

French CA, Rahman S, Walsh EM, K├╝hnle S, Grayson AR, Lemieux ME, Grunfeld N, Rubin BP, Antonescu CR, Zhang S, Venkatramani R, Dal Cin P, Howley PM.

Cancer Discov. 2014 Aug;4(8):928-41. doi: 10.1158/2159-8290.CD-14-0014. Epub 2014 May 29.


The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.

Alekseyenko AA, Walsh EM, Wang X, Grayson AR, Hsi PT, Kharchenko PV, Kuroda MI, French CA.

Genes Dev. 2015 Jul 15;29(14):1507-23. doi: 10.1101/gad.267583.115.


NUT midline carcinoma.

French CA.

Cancer Genet Cytogenet. 2010 Nov;203(1):16-20. doi: 10.1016/j.cancergencyto.2010.06.007. Review.


MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma.

Grayson AR, Walsh EM, Cameron MJ, Godec J, Ashworth T, Ambrose JM, Aserlind AB, Wang H, Evan G, Kluk MJ, Bradner JE, Aster JC, French CA.

Oncogene. 2014 Mar 27;33(13):1736-1742. doi: 10.1038/onc.2013.126. Epub 2013 Apr 22.


[Utility of NUT gene expression and rearrangement in diagnosis of NUT midline carcinoma in upper respiratory tract].

Fang W, French CA, Cameron MJ, Han YD, Liu HG.

Zhonghua Bing Li Xue Za Zhi. 2012 Aug;41(8):519-24. doi: 10.3760/cma.j.issn.0529-5807.2012.08.003. Chinese.


Demystified molecular pathology of NUT midline carcinomas.

French CA.

J Clin Pathol. 2010 Jun;63(6):492-6. doi: 10.1136/jcp.2007.052902. Epub 2008 Jun 13. Review.


Differentiation of NUT midline carcinoma by epigenomic reprogramming.

Schwartz BE, Hofer MD, Lemieux ME, Bauer DE, Cameron MJ, West NH, Agoston ES, Reynoird N, Khochbin S, Ince TA, Christie A, Janeway KA, Vargas SO, Perez-Atayde AR, Aster JC, Sallan SE, Kung AL, Bradner JE, French CA.

Cancer Res. 2011 Apr 1;71(7):2686-96. doi: 10.1158/0008-5472.CAN-10-3513. Epub 2011 Mar 29.


NUT gene rearrangement in a poorly-differentiated carcinoma of the submandibular gland.

Ziai J, French CA, Zambrano E.

Head Neck Pathol. 2010 Jun;4(2):163-8. doi: 10.1007/s12105-010-0174-6. Epub 2010 Mar 30.


NUT midline carcinoma of the larynx: an international series and review of the literature.

Hellquist H, French CA, Bishop JA, Coca-Pelaz A, Propst EJ, Paiva Correia A, Ngan BY, Grant R, Cipriani NA, Vokes D, Henrique R, Pardal F, Vizcaino JR, Rinaldo A, Ferlito A.

Histopathology. 2017 May;70(6):861-868. doi: 10.1111/his.13143. Epub 2017 Feb 21. Review.


Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.

Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, Dal Cin P, Ince TA, Kharchenko PV, Kuroda MI, French CA.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4184-E4192. doi: 10.1073/pnas.1702086114. Epub 2017 May 8.


The importance of diagnosing NUT midline carcinoma.

French CA.

Head Neck Pathol. 2013 Mar;7(1):11-6. doi: 10.1007/s12105-013-0428-1. Epub 2013 Mar 5. Review.


A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights alternative splicing as a contributing oncogenic factor in NUT midline carcinoma.

Stirnweiss A, McCarthy K, Oommen J, Crook ML, Hardy K, Kees UR, Wilton SD, Anazodo A, Beesley AH.

Oncogenesis. 2015 Nov 9;4:e174. doi: 10.1038/oncsis.2015.33.


New developments in the molecular pathogenesis of head and neck tumors: a review of tumor-specific fusion oncogenes in mucoepidermoid carcinoma, adenoid cystic carcinoma, and NUT midline carcinoma.

Bhaijee F, Pepper DJ, Pitman KT, Bell D.

Ann Diagn Pathol. 2011 Feb;15(1):69-77. doi: 10.1016/j.anndiagpath.2010.12.001. Review.


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