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Items: 1 to 20 of 91

1.

On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines.

Johnson CM, Monzingo AF, Ke Z, Yoon DW, Linsky TW, Guo H, Robertus JD, Fast W.

J Am Chem Soc. 2011 Jul 20;133(28):10951-9. doi: 10.1021/ja2033684. Epub 2011 Jun 23.

2.

Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase.

Johnson CM, Linsky TW, Yoon DW, Person MD, Fast W.

J Am Chem Soc. 2011 Feb 9;133(5):1553-62. doi: 10.1021/ja109207m. Epub 2011 Jan 11.

3.
4.

Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.

Linsky TW, Fast W.

Bioorg Med Chem. 2012 Sep 15;20(18):5550-8. doi: 10.1016/j.bmc.2012.07.022. Epub 2012 Aug 3.

5.

Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa.

Stone EM, Costello AL, Tierney DL, Fast W.

Biochemistry. 2006 May 2;45(17):5618-30.

PMID:
16634643
6.

Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase.

Stone EM, Schaller TH, Bianchi H, Person MD, Fast W.

Biochemistry. 2005 Oct 25;44(42):13744-52.

PMID:
16229464
7.

Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.

Wang Y, Monzingo AF, Hu S, Schaller TH, Robertus JD, Fast W.

Biochemistry. 2009 Sep 15;48(36):8624-35. doi: 10.1021/bi9007098.

8.

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.

Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC.

J Am Chem Soc. 2009 Aug 5;131(30):10497-506. doi: 10.1021/ja902694n.

9.

Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.

Tommasi S, Zanato C, Lewis BC, Nair PC, Dall'Angelo S, Zanda M, Mangoni AA.

Org Biomol Chem. 2015 Dec 14;13(46):11315-30. doi: 10.1039/c5ob01843a. Epub 2015 Sep 30.

PMID:
26420019
10.

The electrostatic driving force for nucleophilic catalysis in L-arginine deiminase: a combined experimental and theoretical study.

Li L, Li Z, Wang C, Xu D, Mariano PS, Guo H, Dunaway-Mariano D.

Biochemistry. 2008 Apr 22;47(16):4721-32. doi: 10.1021/bi7023496. Epub 2008 Mar 27.

PMID:
18366187
11.

Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis.

Stone EM, Person MD, Costello NJ, Fast W.

Biochemistry. 2005 May 10;44(18):7069-78.

PMID:
15865451
12.

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

Hartzoulakis B, Rossiter S, Gill H, O'Hara B, Steinke E, Gane PJ, Hurtado-Guerrero R, Leiper JM, Vallance P, Rust JM, Selwood DL.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3953-6. Epub 2007 May 3.

PMID:
17543521
13.
14.

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.

Murray-Rust J, Leiper J, McAlister M, Phelan J, Tilley S, Santa Maria J, Vallance P, McDonald N.

Nat Struct Biol. 2001 Aug;8(8):679-83. Erratum in: Nat Struct Biol 2001 Sep;8(9):818.

PMID:
11473257
17.

Characterization and manipulation of the Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase monomer--dimer equilibrium.

Plevin MJ, Magalhães BS, Harris R, Sankar A, Perkins SJ, Driscoll PC.

J Mol Biol. 2004 Jul 30;341(1):171-84.

PMID:
15312771
18.

Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase.

Ueda S, Kato S, Matsuoka H, Kimoto M, Okuda S, Morimatsu M, Imaizumi T.

Circ Res. 2003 Feb 7;92(2):226-33.

19.

A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1.

Linsky T, Fast W.

J Biomol Screen. 2011 Oct;16(9):1089-97. doi: 10.1177/1087057111417712. Epub 2011 Sep 15.

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