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Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.

Chen M, Pereira-Smith OM, Tominaga K.

Stem Cell Res. 2011 Jul;7(1):75-88. doi: 10.1016/j.scr.2011.04.002. Epub 2011 Apr 25.


Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.

Garcia SN, Kirtane BM, Podlutsky AJ, Pereira-Smith OM, Tominaga K.

FEBS Lett. 2007 Nov 13;581(27):5275-81. Epub 2007 Oct 18.


MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells.

Chen M, Takano-Maruyama M, Pereira-Smith OM, Gaufo GO, Tominaga K.

J Neurosci Res. 2009 May 15;87(7):1522-31. doi: 10.1002/jnr.21976.


Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression.

Marqués-Torrejón MÁ, Porlan E, Banito A, Gómez-Ibarlucea E, Lopez-Contreras AJ, Fernández-Capetillo O, Vidal A, Gil J, Torres J, Fariñas I.

Cell Stem Cell. 2013 Jan 3;12(1):88-100. doi: 10.1016/j.stem.2012.12.001. Epub 2012 Dec 20.


Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability.

Sheu JJ, Guan B, Choi JH, Lin A, Lee CH, Hsiao YT, Wang TL, Tsai FJ, Shih IeM.

J Biol Chem. 2010 Dec 3;285(49):38260-9. doi: 10.1074/jbc.M110.138735. Epub 2010 Oct 5.


Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.

Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL.

Nat Cell Biol. 2011 Dec 4;14(1):73-9. doi: 10.1038/ncb2388.


Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism.

Kuwahara Y, Charboneau A, Knudsen ES, Weissman BE.

Cancer Res. 2010 Mar 1;70(5):1854-65. doi: 10.1158/0008-5472.CAN-09-1922. Epub 2010 Feb 23.


Pitx2 expression promotes p21 expression and cell cycle exit in neural stem cells.

Heldring N, Joseph B, Hermanson O, Kioussi C.

CNS Neurol Disord Drug Targets. 2012 Nov 1;11(7):884-92.


MrgX is not essential for cell growth and development in the mouse.

Tominaga K, Matzuk MM, Pereira-Smith OM.

Mol Cell Biol. 2005 Jun;25(12):4873-80.


AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts.

Xu H, Zhou Y, Coughlan KA, Ding Y, Wang S, Wu Y, Song P, Zou MH.

Biochim Biophys Acta. 2015 Jan;1853(1):65-73. doi: 10.1016/j.bbamcr.2014.10.002. Epub 2014 Oct 13.


MRG15 regulates embryonic development and cell proliferation.

Tominaga K, Kirtane B, Jackson JG, Ikeno Y, Ikeda T, Hawks C, Smith JR, Matzuk MM, Pereira-Smith OM.

Mol Cell Biol. 2005 Apr;25(8):2924-37.


IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells.

Zuo S, Liu C, Wang J, Wang F, Xu W, Cui S, Yuan L, Chen X, Fan W, Cui M, Song G.

J Cancer Res Clin Oncol. 2012 Jun;138(6):1045-55. doi: 10.1007/s00432-012-1153-y. Epub 2012 Mar 6.


Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo.

Roque T, Haton C, Etienne O, Chicheportiche A, Rousseau L, Martin L, Mouthon MA, Boussin FD.

Stem Cells. 2012 Mar;30(3):537-47. doi: 10.1002/stem.1010.


p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A.

Cell Rep. 2013 May 30;3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9.


p53 Binding to the p21 promoter is dependent on the nature of DNA damage.

Hill R, Bodzak E, Blough MD, Lee PW.

Cell Cycle. 2008 Aug 15;7(16):2535-43. Epub 2008 Aug 12.


The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ.

Cell Cycle. 2012 Jul 1;11(13):2458-66. doi: 10.4161/cc.20864. Epub 2012 Jul 1.


p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program.

Pang LY, Scott M, Hayward RL, Mohammed H, Whitelaw CB, Smith GC, Hupp TR.

Cell Cycle. 2011 Mar 15;10(6):932-50. Epub 2011 Mar 15.


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