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Items: 1 to 20 of 89

1.

The Hedgehog's tale: developing strategies for targeting cancer.

Ng JM, Curran T.

Nat Rev Cancer. 2011 May 26;11(7):493-501. doi: 10.1038/nrc3079. Review.

2.

Unraveling the therapeutic potential of the Hedgehog pathway in cancer.

Amakye D, Jagani Z, Dorsch M.

Nat Med. 2013 Nov;19(11):1410-22. doi: 10.1038/nm.3389. Epub 2013 Nov 7. Review.

PMID:
24202394
3.

Mechanisms of Hedgehog signalling in cancer.

Marini KD, Payne BJ, Watkins DN, Martelotto LG.

Growth Factors. 2011 Dec;29(6):221-34. doi: 10.3109/08977194.2011.610756. Epub 2011 Aug 30. Review.

PMID:
21875383
4.

Clinical experience with Hedgehog pathway inhibitors.

Low JA, de Sauvage FJ.

J Clin Oncol. 2010 Dec 20;28(36):5321-6. doi: 10.1200/JCO.2010.27.9943. Epub 2010 Nov 1.

PMID:
21041712
5.

Arsenic: a potentially useful poison for Hedgehog-driven cancers.

Raju GP.

J Clin Invest. 2011 Jan;121(1):14-6. doi: 10.1172/JCI45692. Epub 2010 Dec 22.

6.

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.

Yun JI, Kim HR, Park H, Kim SK, Lee J.

Arch Pharm Res. 2012 Aug;35(8):1317-33. doi: 10.1007/s12272-012-0801-8. Epub 2012 Sep 1. Review.

PMID:
22941475
7.

Hijacking the Hedgehog Pathway in Cancer Therapy.

Laukkanen MO, Castellone MD.

Anticancer Agents Med Chem. 2016;16(3):309-17. Review.

PMID:
26443025
8.

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.

Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, Peaceman D, Ozdemirli M, Rodriguez O, Macdonald TJ, Albanese C, Toretsky JA, Uren A.

J Clin Invest. 2011 Jan;121(1):148-60. doi: 10.1172/JCI42874. Epub 2010 Dec 22.

9.

The utility of hedgehog signaling pathway inhibition for cancer.

Sahebjam S, Siu LL, Razak AA.

Oncologist. 2012;17(8):1090-9. doi: 10.1634/theoncologist.2011-0450. Epub 2012 Jul 31. Review.

10.

[Sonic Hedgehog signaling pathway: from embryology to molecular targeted therapies].

Watson S, Serrate C, Vignot S.

Bull Cancer. 2010 Dec;97(12):1477-83. doi: 10.1684/bdc.2010.1231. Review. French.

11.

Targeting the hedgehog signaling pathway with small molecules.

Kiselyov AS.

Anticancer Agents Med Chem. 2006 Sep;6(5):445-9. Review.

PMID:
17017853
12.

Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.

Rohner A, Spilker ME, Lam JL, Pascual B, Bartkowski D, Li QJ, Yang AH, Stevens G, Xu M, Wells PA, Planken S, Nair S, Sun S.

Mol Cancer Ther. 2012 Jan;11(1):57-65. doi: 10.1158/1535-7163.MCT-11-0691. Epub 2011 Nov 14.

13.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

14.

Locally advanced and metastatic basal cell carcinoma: molecular pathways, treatment options and new targeted therapies.

Ruiz Salas V, Alegre M, Garc├ęs JR, Puig L.

Expert Rev Anticancer Ther. 2014 Jun;14(6):741-9. doi: 10.1586/14737140.2014.895326. Epub 2014 Mar 10. Review.

PMID:
24611655
15.

Hedgehog signaling in basal cell carcinoma.

Otsuka A, Levesque MP, Dummer R, Kabashima K.

J Dermatol Sci. 2015 May;78(2):95-100. doi: 10.1016/j.jdermsci.2015.02.007. Epub 2015 Feb 23. Review.

PMID:
25766766
16.

Hedgehog inhibition as an anti-cancer strategy.

Raju GP, Pham D.

Vitam Horm. 2012;88:507-22. doi: 10.1016/B978-0-12-394622-5.00023-7. Review.

PMID:
22391319
17.

Hedgehog pathway inhibitors: a patent review (2009--present).

Hadden MK.

Expert Opin Ther Pat. 2013 Mar;23(3):345-61. doi: 10.1517/13543776.2013.757304. Epub 2013 Jan 8. Review.

PMID:
23294277
18.

A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.

Chenna V, Hu C, Pramanik D, Aftab BT, Karikari C, Campbell NR, Hong SM, Zhao M, Rudek MA, Khan SR, Rudin CM, Maitra A.

Mol Cancer Ther. 2012 Jan;11(1):165-73. doi: 10.1158/1535-7163.MCT-11-0341. Epub 2011 Oct 25.

19.

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics.

Peukert S, Miller-Moslin K.

ChemMedChem. 2010 Apr 6;5(4):500-12. doi: 10.1002/cmdc.201000011. Review.

PMID:
20229564
20.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

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