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Items: 1 to 20 of 153


The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE.

Pharmacogenet Genomics. 2011 Jul;21(7):403-16. doi: 10.1097/FPC.0b013e328346e8c0.


The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.

Bloom AJ, von Weymarn LB, Martinez M, Bierut LJ, Goate A, Murphy SE.

Pharmacogenet Genomics. 2013 Dec;23(12):706-16. doi: 10.1097/FPC.0000000000000011.


Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.

Bloom AJ, Harari O, Martinez M, Madden PA, Martin NG, Montgomery GW, Rice JP, Murphy SE, Bierut LJ, Goate A.

Hum Mol Genet. 2012 Jul 1;21(13):3050-62. doi: 10.1093/hmg/dds114. Epub 2012 Mar 26.


CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.

Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF.

Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1812-9.


Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

Nakajima M, Fukami T, Yamanaka H, Higashi E, Sakai H, Yoshida R, Kwon JT, McLeod HL, Yokoi T.

Clin Pharmacol Ther. 2006 Sep;80(3):282-97.


Characterization of novel CYP2A6 polymorphic alleles (CYP2A6*18 and CYP2A6*19) that affect enzymatic activity.

Fukami T, Nakajima M, Higashi E, Yamanaka H, Sakai H, McLeod HL, Yokoi T.

Drug Metab Dispos. 2005 Aug;33(8):1202-10. Epub 2005 May 17.


Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.

Nakajima M, Kwon JT, Tanaka N, Zenta T, Yamamoto Y, Yamamoto H, Yamazaki H, Yamamoto T, Kuroiwa Y, Yokoi T.

Clin Pharmacol Ther. 2001 Jan;69(1):72-8.


Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF.

Pharmacogenetics. 2004 Sep;14(9):615-26.


CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

Fukami T, Nakajima M, Sakai H, McLeod HL, Yokoi T.

Pharmacogenomics J. 2006 Nov-Dec;6(6):401-12. Epub 2006 Apr 25.


Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation.

Nakajima M, Yokoi T.

Drug Metab Pharmacokinet. 2005 Aug;20(4):227-35. Review.


The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex.

Zhu AZ, Renner CC, Hatsukami DK, Swan GE, Lerman C, Benowitz NL, Tyndale RF.

Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):708-18. doi: 10.1158/1055-9965.EPI-12-1234-T. Epub 2013 Jan 31.


CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

Benowitz NL, Swan GE, Jacob P 3rd, Lessov-Schlaggar CN, Tyndale RF.

Clin Pharmacol Ther. 2006 Nov;80(5):457-67.


Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, Tyndale RF.

Hum Mutat. 2008 May;29(5):679-88. doi: 10.1002/humu.20698.


Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.

Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers EM, Tyndale RF.

Mol Pharmacol. 2000 Oct;58(4):747-55.


Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.

Ring HZ, Valdes AM, Nishita DM, Prasad S, Jacob P 3rd, Tyndale RF, Swan GE, Benowitz NL.

Pharmacogenet Genomics. 2007 Dec;17(12):1007-15.


Nicotine metabolism and CYP2A6 allele frequencies in Koreans.

Kwon JT, Nakajima M, Chai S, Yom YK, Kim HK, Yamazaki H, Sohn DR, Yamamoto T, Kuroiwa Y, Yokoi T.

Pharmacogenetics. 2001 Jun;11(4):317-23.


Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.

Piliguian M, Zhu AZ, Zhou Q, Benowitz NL, Ahluwalia JS, Sanderson Cox L, Tyndale RF.

Pharmacogenet Genomics. 2014 Feb;24(2):118-28. doi: 10.1097/FPC.0000000000000026.


A novel duplication type of CYP2A6 gene in African-American population.

Fukami T, Nakajima M, Yamanaka H, Fukushima Y, McLeod HL, Yokoi T.

Drug Metab Dispos. 2007 Apr;35(4):515-20. Epub 2007 Jan 31.


Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption.

Bloom AJ, Murphy SE, Martinez M, von Weymarn LB, Bierut LJ, Goate A.

Pharmacogenet Genomics. 2013 Feb;23(2):62-8. doi: 10.1097/FPC.0b013e32835c3b48.


Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries.

Baurley JW, Edlund CK, Pardamean CI, Conti DV, Krasnow R, Javitz HS, Hops H, Swan GE, Benowitz NL, Bergen AW.

Nicotine Tob Res. 2016 Sep;18(9):1837-1844. doi: 10.1093/ntr/ntw117. Epub 2016 Apr 25.

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