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Items: 1 to 20 of 96

1.

The BRCA1 ubiquitin ligase and homologous recombination repair.

Ohta T, Sato K, Wu W.

FEBS Lett. 2011 Sep 16;585(18):2836-44. doi: 10.1016/j.febslet.2011.05.005. Epub 2011 May 9. Review.

2.

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20876-81. doi: 10.1073/pnas.0811203106. Epub 2008 Dec 16.

3.

Homologous repair of DNA damage and tumorigenesis: the BRCA connection.

Jasin M.

Oncogene. 2002 Dec 16;21(58):8981-93. Review.

4.

The role of BRCA1 in DNA double-strand repair: past and present.

Caestecker KW, Van de Walle GR.

Exp Cell Res. 2013 Mar 10;319(5):575-87. doi: 10.1016/j.yexcr.2012.11.013. Epub 2012 Nov 29. Review.

PMID:
23200932
5.

Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks.

Nagaraju G, Scully R.

DNA Repair (Amst). 2007 Jul 1;6(7):1018-31. Epub 2007 Mar 26. Review.

6.

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.

Densham RM, Morris JR.

Nucleus. 2017 Mar 4;8(2):116-125. doi: 10.1080/19491034.2016.1267092. Epub 2016 Dec 29. Review.

7.

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.

J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.

8.

Therapeutic exploitation of tumor cell defects in homologous recombination.

Powell SN, Kachnic LA.

Anticancer Agents Med Chem. 2008 May;8(4):448-60. Review.

PMID:
18473729
9.

RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression.

Wang Y, Deng O, Feng Z, Du Z, Xiong X, Lai J, Yang X, Xu M, Wang H, Taylor D, Yan C, Chen C, Difeo A, Ma Z, Zhang J.

Oncogene. 2016 Mar 17;35(11):1363-72. doi: 10.1038/onc.2015.198. Epub 2015 Aug 3.

10.

A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.

Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR.

Curr Biol. 2012 Sep 25;22(18):1659-66. doi: 10.1016/j.cub.2012.07.034. Epub 2012 Aug 2.

11.

Understanding the functions of BRCA1 in the DNA-damage response.

Yun MH, Hiom K.

Biochem Soc Trans. 2009 Jun;37(Pt 3):597-604. doi: 10.1042/BST0370597.

PMID:
19442256
12.

BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.

Dever SM, White ER, Hartman MC, Valerie K.

Cell Cycle. 2012 Feb 15;11(4):687-94. doi: 10.4161/cc.11.4.19212. Epub 2012 Feb 15. Review.

13.

BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer.

Pothuri B.

Ann Oncol. 2013 Nov;24 Suppl 8:viii22-viii27. doi: 10.1093/annonc/mdt307. Review.

PMID:
24131965
14.

The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings.

Helleday T.

Mol Oncol. 2011 Aug;5(4):387-93. doi: 10.1016/j.molonc.2011.07.001. Epub 2011 Jul 22. Review.

15.

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E.

Nature. 2009 Dec 17;462(7275):886-90. doi: 10.1038/nature08593.

PMID:
20016594
16.

The role of the BRCA1 tumor suppressor in DNA double-strand break repair.

Zhang J, Powell SN.

Mol Cancer Res. 2005 Oct;3(10):531-9. Review.

17.

BRCA1 pathway function in basal-like breast cancer cells.

Hill SJ, Clark AP, Silver DP, Livingston DM.

Mol Cell Biol. 2014 Oct;34(20):3828-42. doi: 10.1128/MCB.01646-13. Epub 2014 Aug 4.

18.

Substrates of the BRCA1-dependent ubiquitin ligase.

Starita LM, Parvin JD.

Cancer Biol Ther. 2006 Feb;5(2):137-41. Epub 2006 Feb 4. Review.

PMID:
16479151
19.

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.

Tutt A, Ashworth A.

Trends Mol Med. 2002 Dec;8(12):571-6. Review.

PMID:
12470990
20.

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM.

Cancer Discov. 2014 Dec;4(12):1430-47. doi: 10.1158/2159-8290.CD-13-0891. Epub 2014 Sep 24.

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