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Items: 1 to 20 of 120

1.

Identification of novel pregnane X receptor activators from traditional Chinese medicines.

Yu C, Chai X, Yu L, Chen S, Zeng S.

J Ethnopharmacol. 2011 Jun 14;136(1):137-43. doi: 10.1016/j.jep.2011.04.022. Epub 2011 Apr 16.

PMID:
21524698
2.

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.

Liu YH, Mo SL, Bi HC, Hu BF, Li CG, Wang YT, Huang L, Huang M, Duan W, Liu JP, Wei MQ, Zhou SF.

Xenobiotica. 2011 Apr;41(4):259-80. doi: 10.3109/00498254.2010.537395. Epub 2010 Nov 30.

PMID:
21117944
3.

[Human pregnane X receptor-mediated transcriptional regulation of CYP3A4 by extracts of 7 traditional Chinese medicines].

Xu Y, Zhang Y, Zhou F, Zheng Y, Zhu X.

Zhongguo Zhong Yao Za Zhi. 2011 Jun;36(11):1524-7. Chinese.

PMID:
22779192
4.

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.

Yu C, Ye S, Sun H, Liu Y, Gao L, Shen C, Chen S, Zeng S.

Chem Biol Interact. 2009 Jan 15;177(1):58-64. doi: 10.1016/j.cbi.2008.08.013. Epub 2008 Sep 2.

PMID:
18805405
5.

Effect of Chinese herbs on CYP3A4 activity and expression in vitro.

Lau C, Mooiman KD, Maas-Bakker RF, Beijnen JH, Schellens JH, Meijerman I.

J Ethnopharmacol. 2013 Sep 16;149(2):543-9. doi: 10.1016/j.jep.2013.07.014. Epub 2013 Jul 20.

PMID:
23876595
6.

Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.

Huang L, Huang M, Li YH, Li RM, Zeng Y, Kuang SY, Zhang L, Wang YT, Bi HC.

J Ethnopharmacol. 2013 Jul 9;148(2):596-602. doi: 10.1016/j.jep.2013.05.008. Epub 2013 May 20. Erratum in: J Ethnopharmacol. 2014 Sep 11;155(2):1399.

PMID:
23702042
7.

[Transcriptional regulation of cytochrome P450 3A4 by four kinds of traditional Chinese medicines].

Dong HY, Shao JW, Chen JF, Wang T, Lin FP, Guo YH.

Zhongguo Zhong Yao Za Zhi. 2008 May;33(9):1014-7, 1089. Chinese.

PMID:
18652346
8.
9.

Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis.

Wan CK, Tse AK, Yu ZL, Zhu GY, Wang H, Fong DW.

Phytomedicine. 2010 Jul;17(8-9):702-5. doi: 10.1016/j.phymed.2009.12.005. Epub 2010 Jan 25.

PMID:
20089387
10.

Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.

Vrzal R, Kubesova K, Pavek P, Dvorak Z.

Toxicol Lett. 2010 Mar 15;193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. Epub 2010 Jan 18.

PMID:
20080160
11.

Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.

Zhang YW, Bao MH, Wang G, Qu Q, Zhou HH.

Pharmazie. 2014 Jul;69(7):532-6.

PMID:
25073399
12.

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E, Gan LS.

Drug Metab Dispos. 2002 Jul;30(7):795-804.

13.

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A by praeruptorin A isolated from the herbal medicine Peucedanum praeruptorum.

Huang L, Bi HC, Li YH, Zhang JQ, Kuang SY, Zhang L, Wang YT, Huang M.

Planta Med. 2013 Nov;79(16):1509-15. doi: 10.1055/s-0033-1350795. Epub 2013 Sep 13.

PMID:
24037590
14.

Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats.

Mu Y, Zhang J, Zhang S, Zhou HH, Toma D, Ren S, Huang L, Yaramus M, Baum A, Venkataramanan R, Xie W.

J Pharmacol Exp Ther. 2006 Mar;316(3):1369-77. Epub 2005 Nov 2.

15.

Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.

Sane RS, Buckley DJ, Buckley AR, Nallani SC, Desai PB.

Drug Metab Dispos. 2008 May;36(5):946-54. doi: 10.1124/dmd.107.018598. Epub 2008 Feb 25.

16.

Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor.

Harmsen S, Meijerman I, Beijnen JH, Schellens JH.

Cancer Chemother Pharmacol. 2009 Jun;64(1):35-43. doi: 10.1007/s00280-008-0842-3. Epub 2008 Oct 7.

PMID:
18839173
17.

Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration.

Zeng H, Li D, Qin X, Chen P, Tan H, Zeng X, Li X, Fan X, Jiang Y, Zhou Y, Chen Y, Wang Y, Huang M, Bi H.

Drug Metab Dispos. 2016 Mar;44(3):337-42. doi: 10.1124/dmd.115.066969. Epub 2015 Dec 10.

19.

Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.

Sekimoto M, Sano S, Hosaka T, Nemoto K, Degawa M.

Biol Pharm Bull. 2012;35(5):677-85.

20.

Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis.

Zhao J, Sun T, Wu JJ, Cao YF, Fang ZZ, Sun HZ, Zhu ZT, Yang K, Liu YZ, Gonzalez FJ, Yin J.

Fitoterapia. 2017 Jun;119:26-31. doi: 10.1016/j.fitote.2017.03.010. Epub 2017 Mar 24.

PMID:
28344076

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